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J-GLOBAL ID：201801020019724351 Update date: Jan. 28, 2025

YANAGISAWA Hiromi

ヤナギサワヒロミ | YANAGISAWA Hiromi

Affiliation and department：
Job title： Professor
Homepage URL (1)： https://www.saggymousehkytsukuba.com

Research field (4)： Pathobiochemistry , Cardiovascular surgery , Medical biochemistry , Cardiology

Research keywords (21)： Elastin , matricellular proteins , fibulins , glycans , Genetic engineering , disease mouse model , aging , cerebrovascular system , tissue stem cell , Raman Imaging , biomechanics , elastic fibers , vascular remodeling , mechanobiology , vascular biology , heritable thoracic aortic disease (HTAD) , vascular injury and vascular remodeling , aortic aneurysm , extracellular matrix , extracellular microenvironment , Aortic Dissection

Research theme for competitive and other funds (29)：

2023 - 2027 Elucidation of the mechanism of thoracic aortic disease based on extracellular matrix and development of novel therapeutic strategy
2021 - 2025 Elucidation of the pathogenesis of aortic dissection caused by the alteration in microfibrils
2024 - 2025 メカノセンシング機構の破綻による大動脈疾患の病態解明とバイオマーカー診断法の開発
2023 - 2024 新規大動脈解離マウスモデルを用いたマルファン症候群等類縁疾患の大動脈解離発症機序の解明
2020 - 2024 上皮幹細胞コンパートメントを規定する分子機構と生物学的意義の解明

2022 - 2023 新規大動脈解離マウスモデルを用いたマルファン症候群等類縁疾患の大動脈解離発症機序の解明

2020 - 2023 Elucidation of the mechanism of aortic aneurysm development based on mechanotransduction and prediction of aortic aneurysm rupture

2021 - 2022 新規大動脈解離マウスモデルを用いたマルファン症候群等類縁疾患の大動脈解離発症機序の解明

2020 - 2022 表皮幹細胞の接着と増殖を担うFibulin-7の生化学特性の解明

2019 - 2020 ラマン分光イメージング法を用いた切迫大動脈瘤の時間的空間解析と破裂予測

2017 - 2020 メカニカルストレス応答の破綻に着目した大動脈瘤形成メカニズムの解明

2015 - 2017 TGFb signaling pathways involved in rupture of aortic aneurysms

2012 - 2015 Role of fibulin-7, a new member of fibulin ECM proteins, in development and disease

2010 - 2015 Loss of extracellular matrix regulation and development of aortic aneurysms

2010 - 2015 Protease regulation and integrity of connective tissues of the pelvic floor

2007 - 2015 Elastic fiber homeostasis in the vaginal wall

2010 - 2014 Fibulin-5 as a regulator of tumor angiogenesis

2009 - 2010 Investigation of the potential role of fibulin-4 in the pathogenesis of Marfan syndrome

2008 - 2010 Fibulin-5 modulates integrin-mediated signaling and alters microenvironment of the vascular wall.

2006 - 2010 Genetic dissection of Hand genes during neural crest development in vivo.

2008 - 2010 Fibulin-5 modulates integrin-mediated signaling and alters microenvironment of the vascular wall.

2006 - 2010 Genetic dissection of Hand genes during neural crest development in vivo.

2003 - 2009 The role of fibulin-5 in cardiovascular remodeling.

2006 - 2009 Novel mechanism of matrix metalloprotease regulation by fibulin-5.

2001 - 2003 The role of novel secreted molecules in the cardiovascular remodeling in vivo.

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Papers (120)：

Hossain, ASM Sakhawa, Clarin, Maria Thea, Rane, Dela Cruz, Kimura, Kenichi, Biggin, George, Taga, Yuki, Uto, Koichiro, et al. Fibrillin-1 G234D mutation in the hybrid1 domain causes tight skin associated with dysregulated elastogenesis and increased collagen cross-linking in mice. MATRIX BIOLOGY. 2024. 135. 24-38
Dubacher, Nicolo, Sugiyama, Kaori, Smith, Jeffrey D, Nussbaumer, Vanessa, Csonka, Máté, Ferenczi, Szilamér, Kovács, Krisztina J, Caspar, Sylvan M, Lamberti, Lisa, et al. Novel Insights into the Aortic Mechanical Properties of Mice Modeling Hereditary Aortic Diseases. THROMBOSIS AND HAEMOSTASIS. 2024. Epub
Kimura, Kenichi, Motoyama, Eri, Kanki, Sachiko, Asano, Keiichi, Sheikh, Md Al Amin, Clarin, Maria Thea, Rane, Dela Cruz, Raja, Erna, et al. A novel genetic mouse model of fatal aortic dissection reveals massive inflammatory cell infiltration in the thoracic aorta. Biorxiv. 2024
Torimoto, Keiichi, Elliott, Katherine, Nakayama, Yuki, Yanagisawa, Hiromi, Eguchi, Satoru. Cardiac and perivascular myofibroblasts, matrifibrocytes, and immune fibrocytes in hypertension; commonalities and differences with myocardial infarction and other cardiovascular diseases. Cardiovascular research. 2024
Violette, Deleeuw, Carlson, Eric, Renard, Marjolijn, Zientek, Keith D, Wilmarth, Phillip A, Reddy, Ashok P, Manalo, Elise C, Tufa, Sara F, Keene, Douglas R, Olbinado, Margie, et al. Unraveling the Role of TGFβ Signaling in Thoracic Aortic Aneurysm and Dissection Using Fbn1 Mutant Mouse Models. MATRIX BIOLOGY. 2023. 123. 17-33

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MISC (12)：

柳沢裕美, 中邨智之. 血管におけるマトリクスエイジング. バイオマテリアルー生体材料ー. 2020. 38. 3. 172-177
船戸紀子, Srivastava Deepak, Yanagisawa Hiromi. 転写因子Tbx1はヒト口蓋裂の疾患遺伝子の発現調節により口蓋の発生に関与する. Journal of Oral Biosciences Supplement. 2018. 2018. 407-407
Tomoko Okuyama, Jun Shirakawa, Hiromi Yanagisawa, Yasuo Terauchi. Identification of Matricellular Protein Fibulin-5 as a Target Molecule of Glucokinase-Mediated Calcineurin/NFAT Signaling in Pancreatic Islets. DIABETES. 2017. 66. A584-A584
Tomoko Okuyama, Jun Shirakawa, Hiromi Yanagisawa, Yasuo Terauchi. Fibulin5 Deficiency Improved Insulin Resistance and Hepatic Steatosis Induced by High-Fat Feeding. DIABETES. 2015. 64. A492-A493
Jacopo Ferruzzi, Matthew Bersi, Stuart Campbell, Hiromi Yanagisawa, Jay D. Humphrey. Characterization of central artery stiffness, hemodynamics, and left ventricular function in a mouse model of accelerated aging. ANGIOGENESIS. 2014. 17. 1. 276-276

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Books (5)：

Biomechanics of the Aorta: Modelling for Patient Care
Elsevier 2024
血管・リンパ管の機能制御と疾患メカニズム
化学同人 2022 ISBN:9784759817355
心臓
日本医学出版 2022
医学のあゆみ
2019
Advances in Stem Cells and their Niches
2019

Lectures and oral presentations (134)：

Anti-inflammatory Nanoparticles as Potential Treatment for Aortic Dissection
(つくば医工連携フォーラム2025)
遺伝性胸部大動脈疾患におけるメカノトランスダクション異常
(CVMW 2024)
Phenotypic changes of endothelial cells in the pathogenesis of aortic dissection.
(CVMW 2024)
骨髄ニッチにおけるミクロフィブリルを介した造血制御機構の解明
(第8回エラスチン・関連分子研究会)
フィブリリン1遺伝子変異による大動脈解離病態に関わる血管内皮細胞の機能解析
(第8回エラスチン・関連分子研究会)

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Education (2)：

1988 - 1993 Graduate School of University of Tsukuba
1980 - 1986 University of Tsukuba School of Medicine

Professional career (1)：

Ph.D. (University of Tsukuba)

Work history (10)：

2024/04 - 現在筑波大学TARAセンターセンター長・教授
2015/09 - 現在 University of Tsukuba TARA Center Professor
2020/04 - 2022/03 筑波大学学長補佐
2014/09 - 2015/08 University of Tsukuba TARA Center Professor
2011/09 - 2015/08 University of Texas Southwestern Medical Center at Dallas Department of Molecular Biology Associate Professor (Tenured)

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Committee career (19)：

2024/04 - 現在日本結合組織学会理事長
2022/01 - 現在 International Society for Matrix Biology Council member
2022/01 - 現在 Matrix Biology and Matrix Biology Plus Editor
2021/12 - 現在 Vascular Pharmacology Editorial Board Member
2021/09 - 現在 Frontiers in Cardiovascular Medicine Associate Editor (Atherosclerosis and Vascular Medicine)

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Awards (5)：

2016 - Mizutani Foundation for Glycoscience
2015 - 上原記念生命科学財団研究助成
2015 - 内藤記念科学財団研究助成
2012 - American Heart Association Established Investigator Award (AHA)
2008 - American Society for Matrix Biology Junior Investigator Award (ASMB)

Association Membership(s) (16)：

European Society of Cardiology , International Society for Matrix Biology , THE JAPANESE SOCIETY FOR CARDIOVASCULAR SURGERY , The Japanese Biochemical Society , The Molecular Biology Society of Japan , 日本循環器学会 , Japan Elastin Meeting , Jananese Society for Matirx Biology and Medicine , 日本血管生物医学会 , 日本心血管内分泌代謝学会 , North American Vascular Biology Organization , American Heart Association (AHA), 2017- FAHA , American Society for Matrix Biology , Japanese Society for Matrix Biology and Medicine , JAPAN PEDIATRIC SOCIETY , 老化促進モデルマウス(SAM)学会

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