Unoki Takamitsu

ウノキタカミツ | Unoki Takamitsu

Affiliation and department：
Job title：主任研究員
Homepage URL (2)： http://nimd.env.go.jp/about/organization/member16.html , http://nimd.env.go.jp/english/about/organization/member16.html

Research field (1)： Pharmaceuticals - health and biochemistry

Research keywords (4)： Neuroscience , Redox Biology , Reactive sulfur species , Methylmercury

Research theme for competitive and other funds (5)：

2024 - 2027 超硫黄化を介したタンパク質機能制御のメチル水銀による撹乱と毒性機序の解明
2022 - 2025 Development of biomarkers that can objectively determine differences in individual susceptibility to methylmercury poisoning
2021 - 2024 メチル水銀によるレドックス制御因子の変動を起点とした神経機能変化の素過程解明
2019 - 2022 活性イオウ分子に着目したメチル水銀の選択的細胞傷害に関する研究
2016 - 2018 Research on detoxification mechanism of environmental electrophiles mediated by reactive sulfur species

Papers (24)：

Masatake Fujimura, Takamitsu Unoki. BDNF specifically expressed in hippocampal neurons is involved in methylmercury neurotoxicity resistance. Environmental Toxicology. 2024. 39. 5. 3149-3159
Masahiro Akiyama, Takamitsu Unoki, Hanako Aoki, Akiyuki Nishimura, Yasuhiro Shinkai, Eiji Warabi, Kazuhiro Nishiyama, Yuka Furumoto, Naohiko Anzai, Takaaki Akaike, et al. Cystine-dependent antiporters buffer against excess intracellular reactive sulfur species-induced stress. Redox Biology. 2022. 57. 102514-102514
Masatake Fujimura, Takamitsu Unoki. Preliminary evaluation of the mechanism underlying vulnerability/resistance to methylmercury toxicity by comparative gene expression profiling of rat primary cultured cerebrocortical and hippocampal neurons. The Journal of Toxicological Sciences. 2022. 47. 5. 211-219
Sawako Horai, Yumi Abiko, Takamitsu Unoki, Yasuhiro Shinkai, Masahiro Akiyama, Katsushi Nakata, Tatsuya Kunisue, Yoshito Kumagai. Concentrations of nucleophilic sulfur species in small Indian mongoose (Herpestes auropunctatus) in Okinawa, Japan. Chemosphere. 2022. 295. 133833-133833
Takamitsu Unoki, Masahiro Akiyama, Yasuhiro Shinkai, Yoshito Kumagai, Masatake Fujimura. Spatio-temporal distribution of reactive sulfur species during methylmercury exposure in the rat brain. The Journal of toxicological sciences. 2022. 47. 1. 31-37

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MISC (42)：

鵜木隆光, 秋山雅博, 熊谷嘉人, 藤村成剛. メチル水銀によるタンパク質結合性超硫黄分子の変動. Fundamental Toxicological Sciences (Web). 2022. 9. Supplement
青木はな子, 秋山雅博, 鵜木隆光, 蕨栄治, 西村明幸, 西田基宏, 熊谷嘉人, 秋山雅博, 鵜木隆光, 蕨栄治, et al. Excess supersulfide is exported through cystine-dependent antiporters. 衛生薬学・環境トキシコロジー講演要旨集. 2022. 2022
鵜木隆光, 秋山雅博, 熊谷嘉人, 藤村成剛. Sulfane sulfur transition during methylmercury exposure in the cells. 衛生薬学・環境トキシコロジー講演要旨集. 2022. 2022
青木はな子, 秋山雅博, 秋山雅博, 鵜木隆光, 鵜木隆光, 蕨英治, 蕨英治, 西村明幸, 西田基宏, 熊谷嘉人, et al. Export of excess reactive sulfur species through cystine-dependent antiporters. Journal of Toxicological Sciences. 2022. 47. Supplement (CD-ROM)
鵜木隆光, 秋山雅博, 熊谷嘉人, 藤村成剛. Sulfane sulfur transition in the cells during methylmercury exposure. Journal of Toxicological Sciences. 2022. 47. Supplement (CD-ROM)

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Lectures and oral presentations (36)：

メチル水銀によるタンパク質超硫黄化変動の網羅的解析
(メタルバイオサイエンス研究会2023 2023)
Alterations in protein polysulfidation induced by methylmercury exposure
(Forum 2023 Pharmaceutical Health Sciences ・ Environmental Toxicology 2023)
Cystine-dependent antiporters prevent sulfur stress by excreting surplus supersulfide from cells
(The 50th Annual Meeting of the Japanese Society of Toxicology 2023)
Protective Function of Supersulfides against Methylmercury Toxicity
(NIMD Forum 2022 2022)
メチル水銀によるタンパク質結合性超硫黄分子の変動
(メタルバイオサイエンス研究会2022 2022)

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Education (3)：

Professional career (1)：

Work history (6)：

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Committee career (2)：

Awards (4)：

2019 - 令和元年度メチル水銀研究ミーティング若手研究奨励賞
2012 - 筑波大学人間総合科学研究科研究科長賞
2011 - The 2nd Leading Graduate Schools International Conference, Young Scientist Award
2009 - 第3回つくば医科学研究交流会つくば医科学特別賞

Association Membership(s) (2)：

日本分子生物学会 , THE JAPANESE SOCIETY OF TOXICOLOGY

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