Nagase Hiroshi

ナガセヒロシ | Nagase Hiroshi

Affiliation and department：
Homepage URL (1)： http://nagase.wpi-iiis.tsukuba.ac.jp/

Research field (1)： Pharmaceuticals - chemistry and drug development

Research keywords (4)： Orexin , Opioid , Organic Chemistry , Medicinal Chemistry

Research theme for competitive and other funds (7)：

2018 - 2022 「NC-2800塩酸塩脳波解析」及び「NC-2800塩酸塩全合成検討」
2015 - 2020 超ストレス環境・宇宙を見据えた新規睡眠覚醒制御手法の開発
2016 - 2019 新規オレキシンリガンドの創出と薬理作用の解明
2016 - 2018 情動系を調節するオピオイドδ受容体作動薬の開発
2015 - 2016 情動系を調節するオピオイドδ受容体作動薬の開発

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Papers (175)：

Yamada D, Yanagisawa S, Yoshizawa K, Yanagita S, Oka JI, Nagase H, Saitoh A. Selective agonists of the δ-opioid receptor, KNT-127 and SNC80, act differentially on extinction learning of contextual fear memory in mice. Neuropharmacology. 2019. 160. 107792
Nagase H, Saitoh A. Research and development of κ opioid receptor agonists and δ opioid receptor agonists. Pharmacology & therapeutics. 2019. 107427
Saitoh T, Seki K, Nakajima R, Yamamoto N, Kutsumura N, Nagumo Y, Irukayama-Tomobe Y, Ogawa Y, Ishikawa Y, Tanimura R, et al. Essential structure of orexin 1 receptor antagonist YNT-707, Part IV: The role of D-ring in 4,5-epoxymorphinan on the orexin 1 receptor antagonistic activity. Bioorganic & medicinal chemistry letters. 2019. 29. 18. 2655-2658
Mustafa Korkutata, Tsuyoshi Saitoh, Yoan Cherasse, Shuji Ioka, Feng Duo, Rujie Qin, Nobuyuki Murakoshi, Shinya Fujii, Xuzhao Zhou, Fumihiro Sugiyama, et al. Corrigendum to "Enhancing endogenous adenosine A2A receptor signaling induces slow-wave sleep without affecting body temperature and cardiovascular function" [Neuropharmacology 144 (2019) 122-132]. Neuropharmacology. 2019. 153. 153-153
Yamamoto N, Ohrui S, Okada T, Saitoh T, Kutsumura N, Nagumo Y, Irukayama-Tomobe Y, Ogawa Y, Ishikawa Y, Watanabe Y, et al. Essential structure of orexin 1 receptor antagonist YNT-707, part III: Role of the 14-hydroxy and the 3-methoxy groups in antagonistic activity toward the orexin 1 receptor in YNT-707 derivatives lacking the 4,5-epoxy ring. Bioorganic & medicinal chemistry. 2019. 27. 8. 1747-1758

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Patents (16)：

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Lectures and oral presentations (65)：

オピオイド受容体を標的とする創薬
(日本睡眠学会第43回定期学術集会 2018)
睡眠・覚醒の謎に挑む~副題:睡眠病の治療薬を目指して~
(くすりと健康2018 春季講演会 2018)
難治性そう痒症治療薬の研究開発
(創薬薬理フォーラム第64回談話会 2018)
難治性掻痒症治療薬の開発研究
(慢性肝疾患と関連疾患を考える会 2018)
オレキシン受容体選択的リガンドの設計・合成
(第40回白金シンポジウム 2018)

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Professional career (1)：

理学博士 (名古屋大学)

Awards (10)：

2015 - THE PHARMACEUTICAL SOCIETY OF JAPAN Division of Medicinal Chemistry Medicinal Chemistry Symposium Award
2014 - Foundation for Promotion of Material Science and Technology of Japan The 14th Yamazaki-Teiichi Prize
2013 - Japan Institute of Invention and Innovation The Invention Prize, Japan on the National Commendation of Invention
2013 - Okochi Memorial Foundation Okochi Memorial Technology Prize
2009 - The Pharmaceutical Society of Japan Drug-Discovery Science Award, Japan

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Association Membership(s) (7)：

Japanese Narcotics Research Conference , THE CHEMICAL SOCIETY OF JAPAN , THE PHARMACEUTICAL SOCIETY OF JAPAN Division of Medicinal Chemistry , THE PHARMACEUTICAL SOCIETY OF JAPAN , 新規素材探索研究会 , American Chemical Society , THE SOCIETY OF SYNTHETIC ORGANIC CHEMISTRY, JAPAN

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