OHKANDA Junko

オオカンダジュンコ | OHKANDA Junko

Affiliation and department：
Job title： Professor
Homepage URL (1)： http://www.shinshu-u.ac.jp/faculty/agriculture/lab/johkanda/index.html

Research field (2)： Chemical biology , Pharmaceuticals - chemistry and drug development

Research keywords (12)： fusicoccin , 14-3-3 proteins , protein-protein interactions , intrinsically disordered proteins and regions , Pharmaceutical and plant hormones , Antitumor agents , Signaling pathways , Posttranslational modification , Natural products , Peptides , inhibitors , rational design, fusicoccins, peptidomimetics, KRas

Research theme for competitive and other funds (18)：

2021 - 2024 Chemical regulation of intrinsically disordered proteins in animal and plant cells
2020 - 2022 Rational design of peptidomimetic inhibitors for posttranslational lipdation of K-Ras
2020 - 2022 Natural product-based chemical tools for elucidation and regulation of 14-3-3-signaling pathways
2018 - 2021 Synthetic molecular approaches toward controlling intrinsically disordered proteins
2018 - 2020 天然物およびペプチド基盤型合成中分子による細胞内信号伝達系の制御

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Papers (92)：

Hironaru Kiriyama, Satoru N Kinoshita, Yuki Hayashi, Rikako Honda, Shigemitsu Kasuga, Toshinori Kinoshita, Hiroki Irieda, Junko Ohkanda. Fungal toxin fusicoccin enhances plant growth by upregulating 14-3-3 interaction with plasma membrane H+-ATPase. Scientific reports. 2024. 14. 1. 23431-23431
Kazuya Yamanaka, Yoshihisa Inoue, Miki Imanishi, Junko Ohkanda. Functional evaluation of an electrophilic focused library to identify a covalent inhibitor against intrinsically disordered circadian clock transcription factors. Bioorganic & medicinal chemistry letters. 2024. 98. 129588-129588
Kenta Tanaka, Yoshiya Hatano, Junko Ohkanda. Isoform-selective fluorescent labeling of 14-3-3sigma by acrylamide-containing fusicoccins. Chem. Eur. J. 2023. 29. 41. e202301059
Nanami Ogino, Ryoma Masuda, Louvy Lynn Punzalan, Emi Yamashita, Shota Igaue, Yoshihisa Inoue, Junko Ohkanda. Structure-activity-relationship study of semi-synthetically modified fusicoccins on their stabilization effect for 14-3-3-phospholigand interactions. Bioorganic & Medicinal Chemistry. 2022. 73. 117020-117020
Ninako Kimura, Kanako Saito, Takashi Niwa, Masato Yamakawa, Shota Igaue, Junko Ohkanda, Takamitsu Hosoya, Isao Kii. Expression and purification of DYRK1A kinase domain in complex with its folding intermediate-selective inhibitor FINDY. Protein expression and purification. 2022. 195-196. 106089-106089

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MISC (6)：

Katoh Akira, Fujimoto Takeshi, Ohkanda Junko. The Ring-Opening Reaction of Benzimidazoles with 2-Chloro-or 2,3-Dichloro-6-nitroquinoxaline. Technical reports of Seikei University. 2000. 37. 1. 7-12
Katoh Akira, Okuyama Koji, Fukuchi Takashi, Ohkanda Junko. The Product-Solution pH Relationship on the Reaction of Amino Acid N?Benzyloxyamide with Biacetyl. Technical reports of Seikei University. 2000. 37. 1. 13?18
大神田淳子, 加藤明良. 機能性N-ヒドロキシアミド含有複素環化合物-合成・反応・金属錯体形成能-(共著). 有機合成化学協会誌. 1997. 55. 6. 524-534
Katoh Akira, Hirono Nobutaka, Taniguchi Takayuki, Ohkanda Junko. Chemical Modification of the Nitoro Group of 4-Nitro-L-Phenylalanine. Technical reports of Seikei University. 1997. 34. 1. 7-12
Katoh Akira, Fujisaki Yoshiyuki, Ohkanda Junko. Reaction of 2,3-Dichloro-6-nitroquinoxaline with Amino Acids. Technical reports of Seikei University. 1995. 32. 2. 57-60

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Books (2)：

Chemical approach toward controlling of transient protein interactions, published in Middle Molecular Strategy
Springer, Singapore 2021 ISBN:9789811624575
Self-assembled receptors for protein surface recognition, published in Comprehensive Supramolecular Chemistry II
Elsevier, Oxford 2017

Professional career (1)：

Ph.D. (The University of Tokyo)

Work history (8)：

2016/10 - 現在 Shinshu University
2013 - 2016 Associate Professor, ICR, Kyoto University
2005 - 2013 Associate Professor, ISIR, Osaka University
2004 - 2005 Lecturer, Tokyo Gakugei University
2003/01 - 2003/12 Researcher, Achillion Pharmaceuticals, Inc. (Connecticut, USA)

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Committee career (16)：

2022 - 現在日本学術振興会学術システム研究センター研究員
2022 - 現在 Wiley-VCH Chemistry A European Journal, Editorial board member
2021/02 - 現在日本薬学会代議員
2020 - 現在科学技術振興機構創発的研究支援事業創発アドバイザー
2018/02 - 現在近畿化学協会代議員

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Awards (2)：

2016 - 第21回日本女性科学者の会奨励賞
2008 - 日本学術振興会平成20年度科学研究費補助金第1段審査員表彰

Association Membership(s) (8)：

日本ケミカルバイオロジー学会 , International Chemical Biology Society , 近畿化学協会 , The Society of Synthetic Organic Chemistry, Japan , American Chemical Society , 日本農芸化学会 , The Pharmaceutical Society of Japan , The Chemical Society of Japan

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