Rchr
J-GLOBAL ID：201801021134687768   Update date: Sep. 30, 2024

Aoki Shigeki

アオキ シゲキ | Aoki Shigeki
Affiliation and department：
Chiba University

About Chiba University


Job title： Associate Professor
Homepage URL  (1)： http://www.p.chiba-u.jp/lab/yakuzai/
Research field  (1)： Clinical pharmacy
Research keywords  (4)： ミトコンドリア ,  HLA ,  特異体質薬物毒性 ,  がん代謝
Research theme for competitive and other funds  (23)：
  • 2023 - 2028 HLAの翻訳後修飾・輸送に着目した自己免疫の理解
  • 2023 - 2025 HLAの翻訳後修飾・輸送の違いを考慮した自己認識免疫バランスの重要性
  • 2022 - 2025 Mechanistic study of sulfa drug-induced severe cutaneous adverse reactions by focusing on HLA-A*11:01
  • 2021 - 2025 Scientific research of the onset mechanism of drug-induced idiosyncratic toxicity to avoid serious side effects
  • 2023 - 2024 HLAの翻訳後修飾・輸送機構の理解に基づいた薬物副作用の制御
Show all
Papers (38)：
  • Natsumi Hama, Shigeki Aoki, Chun-Bing Chen, Akito Hasegawa, Youichi Ogawa, Marc Vocanson, Hideo Asada, Chia-Yu Chu, Cheng-Che E Lan, Roni P Dodiuk-Gad, et al. Recent progress of Stevens-Johnson syndrome/toxic epidermal necrolysis: Diagnosis criteria, pathogenesis and therapy. British Journal of Dermatology. 2024
  • Shigeki Aoki. Elucidating the Mechanisms Underlying Interindividual Differences in the Onset of Adverse Drug Reactions. Biological and Pharmaceutical Bulletin. 2024. 47. 6. 1079-1086
  • Zhiheng Zhang, Haruna Aoki, Keitaro Umezawa, Joshua Kranrod, Natsumi Miyazaki, Taichi Oshima, Takuya Hirao, Yuri Miura, John Seubert, Kousei Ito, et al. Potential role of lipophagy impairment for anticancer effects of glycolysis-suppressed pancreatic ductal adenocarcinoma cells. Cell Death Discovery. 2024. 10. 1
  • Akira Kazaoka, Sota Fujimori, Yushiro Yamada, Tomohiro Shirayanagi, Yuying Gao, Saki Kuwahara, Naoki Sakamoto, Takeshi Susukida, Shigeki Aoki, Kousei Ito. HLA-B*57:01-dependent intracellular stress in keratinocytes triggers dermal hypersensitivity reactions to abacavir. PNAS Nexus. 2024. 3. 4
  • Motoyasu Satou, Jason Wang, Tae Nakano-Tateno, Mariko Teramachi, Shigeki Aoki, Hiroyuki Sugimoto, Constance Chik, Toru Tateno. Autophagy inhibition suppresses hormone production and cell growth in pituitary tumor cells: A potential approach to pituitary tumors. Molecular and Cellular Endocrinology. 2024. 112196-112196
ｍore...
MISC (83)：
  • SHUN Shiyori, SHUN Shiyori, 薄田健史, 白柳智弘, 青木重樹, 伊藤晃成, 早川芳弘. Development of a novel cancer immunotherapy based on tumor immunogenicity improvement by carbamazepine and HLA-B*15:02 interaction. 日本薬学会年会要旨集(Web). 2024. 144th
  • 薄田健史, SUN Yuchen, 青木重樹, 伊藤晃成, 早川芳弘. An important role of glycolysis in CD8+ T cells in the onset of HLA-mediated idiosyncratic drug toxicity. 日本薬学会年会要旨集(Web). 2024. 144th
  • Takeshi Susukida, So-Ichiro Sasaki, Tomohiro Shirayanagi, Shigeki Aoki, Kousei Ito, Yoshihiro Hayakawa. Development of a novel strategy for cancer immunotherapy based on tumor immunogenicity improvement by HLA-drug interaction. CANCER RESEARCH. 2023. 83. 7
  • 薄田健史, 青木重樹, SUN Yuchen, 早川芳弘. Glycolysis in CD8+ T cells plays an important role in the onset of HLA-mediated idiosyncratic drug toxicity. 日本免疫毒性学会学術年会講演要旨集. 2023. 30th
  • 平尾 卓也, 根上 窓花, 佐々木 文音, 宮田 七歌, 青木 重樹, 手塚 千裕, 加藤 芳徳, 山田 治美. ミトコンドリアを標的としたBcr-Abl陽性白血病に対する効率的な薬物併用療法の立案. 日本薬学会年会要旨集. 2022. 142年会. 27PO10-16
ｍore...
Books (3)：
  • BIO Clinica
    北隆館 2020
  • 血液内科
    科学評論社 2018
  • academist Journal
    academist Journal 2017
Lectures and oral presentations  (195)：
  • Optimizing Energy Metabolism for the Treatment of Pancreatic Cancer
    (CSPS/CC-CRS Symposium 2024)
  • Potential role of lipophagy inhibition for anticancer effects of glycolysis-suppressed pancreatic ductal adenocarcinoma cells
    (2024 CSPS/CC-CRS Symposium 2024)
  • Glycolysis in CD8+ T cells regulates the onset of abacavir-induced skin toxicity in HLA-B*57:01 transgenic mice
    (2024 CSPS/CC-CRS Symposium 2024)
  • 薬物過敏症発症におけるCD8+ T細胞の解糖系代謝の重要性
    (日本薬学会 第144年会 2024)
  • キナーゼ阻害剤の薬効評価を目的とした簡便な同種移植白血病モデルマウスの作出
    (日本薬学会 第144年会 2024)
ｍore...
Education (4)：
  • 2010 - 2013 The University of Tokyo Graduate School of Pharmaceutical Sciences Department of Pharmaceutical Technology
  • 2008 - 2010 The University of Tokyo Graduate School of Pharmaceutical Sciences Department of Pharmaceutical Technology
  • 2006 - 2008 The University of Tokyo Faculty of Pharmaceutical Sciences Department of Pharmacy
  • 2004 - 2006 The University of Tokyo College of Arts and Sciences
Professional career (1)：
  • 博士(薬学) (東京大学)
Work history (6)：
  • 2024/10 - 現在 Chiba University Graduate School of Pharmaceutical Sciences Associate Professor
  • 2019/04 - 2024/09 Chiba University Graduate School of Pharmaceutical Sciences Lecturer
  • 2018/11 - 2019/03 Chiba University Graduate School of Pharmaceutical Sciences
  • 2013/11 - 2018/10 Chiba University Graduate School of Pharmaceutical Sciences
  • 2013/04 - 2013/10 Pharmaceuticals and Medical Devices Agency
Show all
Committee career (4)：
  • 2022/10 - 現在 日本免疫毒性学会 連携学会委員
  • 2022/10 - 現在 日本免疫毒性学会 学術編集委員
  • 2022/07 - 現在 日本毒性学会 評議員
  • 2019/10 - 現在 日本免疫毒性学会 評議員
Awards (9)：
  • 2023/04 - 化学情報協会 JAICI賞 薬物副作用の個人差の背景に潜むメカニズムの解明
  • 2023/03 - The Pharmaceutical Society of Japan Award for Young Scientists Elucidation of mechanism underlying individual differences in adverse drug reactions
  • 2021/11 - 日本薬物動態学会 第36回年会 ベストポスター賞 Elimination of Immunosuppressive Factors Clearly Exhibits Idiosyncratic Toxicity by Abacavir in HLA-B*57:01-Transgenic Mice
  • 2021/07 - 日本毒性学会 技術賞 ヒトHLAトランスジェニックマウスを用いた特異体質薬物毒性理解への取り組み
  • 2020/09 - 日本薬学会関東支部 奨励賞 薬物による副作用発症の個人差を決定するHLAの重要性
Show all
Association Membership(s) (6)：
THE JAPANESE SOCIETY FOR THE STUDY OF XENOBIOTICS ,  THE MOLECULAR BIOLOGY SOCIETY OF JAPAN ,  THE JAPANESE SOCIETY OF TOXICOLOGY ,  日本免疫毒性学会 ,  THE JAPANESE CANCER ASSOCIATION ,  THE PHARMACEUTICAL SOCIETY OF JAPAN
※ Researcher’s information displayed in J-GLOBAL is based on the information registered in researchmap. For details, see here.

Return to Previous Page

TOP

BOTTOM