2015 - 2019 Elucidation of the pathogenesis of idiosyncratic drug-induced liver injury using HLA-transfected mice for establishment of preclinical prediction method
2018 - 2018 破骨細胞のライフサイクルを決定するオートファジー
2017 - 2017 免疫反応の恒常性維持にオートファジーは重要か?
2015 - 2017 Elucidation of the onset mechanism of abacavir-induced severe skin reaction using humanized model animal
2015 - 2016 がんエクソソームに着目した慢性骨髄性白血病治療時の薬剤耐性機構に関する研究
2015 - 2015 次世代の癌治療を目指した癌エクソソームの生物学的意義の解析
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Papers (37)：
Shigeki Aoki. Elucidating the Mechanisms Underlying Interindividual Differences in the Onset of Adverse Drug Reactions. Biological and Pharmaceutical Bulletin. 2024. 47. 6. 1079-1086
Zhiheng Zhang, Haruna Aoki, Keitaro Umezawa, Joshua Kranrod, Natsumi Miyazaki, Taichi Oshima, Takuya Hirao, Yuri Miura, John Seubert, Kousei Ito, et al. Potential role of lipophagy impairment for anticancer effects of glycolysis-suppressed pancreatic ductal adenocarcinoma cells. Cell Death Discovery. 2024. 10. 1
Akira Kazaoka, Sota Fujimori, Yushiro Yamada, Tomohiro Shirayanagi, Yuying Gao, Saki Kuwahara, Naoki Sakamoto, Takeshi Susukida, Shigeki Aoki, Kousei Ito. HLA-B*57:01-dependent intracellular stress in keratinocytes triggers dermal hypersensitivity reactions to abacavir. PNAS Nexus. 2024. 3. 4
Motoyasu Satou, Jason Wang, Tae Nakano-Tateno, Mariko Teramachi, Shigeki Aoki, Hiroyuki Sugimoto, Constance Chik, Toru Tateno. Autophagy inhibition suppresses hormone production and cell growth in pituitary tumor cells: A potential approach to pituitary tumors. Molecular and Cellular Endocrinology. 2024. 112196-112196
Akira Kazaoka, Kazuyoshi Kumagai, Junya Matsushita, Tetsuo Aida, Saki Kuwahara, Shigeki Aoki, Kousei Ito. Pathological changes in various organs in HLA-B*57:01 transgenic mice with abacavir-induced skin eruption. Toxicological Research. 2024
Takeshi Susukida, So-Ichiro Sasaki, Tomohiro Shirayanagi, Shigeki Aoki, Kousei Ito, Yoshihiro Hayakawa. Development of a novel strategy for cancer immunotherapy based on tumor immunogenicity improvement by HLA-drug interaction. CANCER RESEARCH. 2023. 83. 7
薄田健史, 青木重樹, SUN Yuchen, 早川芳弘. Glycolysis in CD8+ T cells plays an important role in the onset of HLA-mediated idiosyncratic drug toxicity. 日本免疫毒性学会学術年会講演要旨集. 2023. 30th
張智恒, 青木春菜, 平尾卓也, 青木重樹. LSD1 inhibitors provide a promising therapeutic strategy of pancreatic cancers through LSD1-independent manner. 日本癌学会学術総会抄録集(Web). 2022. 81st
薄田健史, 青木重樹, 白柳智弘, 伊藤晃成, 早川芳弘. Development of a novel anti-cancer immunotherapy based on tumor immunogenicity improvement by the interaction between abacavir and HLA-B*57:01. 日本薬学会年会要旨集(Web). 2022. 142nd
Optimizing Energy Metabolism for the Treatment of Pancreatic Cancer
(CSPS/CC-CRS Symposium 2024)
Potential role of lipophagy inhibition for anticancer effects of glycolysis-suppressed pancreatic ductal adenocarcinoma cells
(2024 CSPS/CC-CRS Symposium 2024)
Glycolysis in CD8+ T cells regulates the onset of abacavir-induced skin toxicity in HLA-B*57:01 transgenic mice
(2024 CSPS/CC-CRS Symposium 2024)
2010 - 2013 The University of Tokyo Graduate School of Pharmaceutical Sciences Department of Pharmaceutical Technology
2008 - 2010 The University of Tokyo Graduate School of Pharmaceutical Sciences Department of Pharmaceutical Technology
2006 - 2008 The University of Tokyo Faculty of Pharmaceutical Sciences Department of Pharmacy
2004 - 2006 The University of Tokyo College of Arts and Sciences
Professional career (1)：
博士(薬学) (東京大学)
Work history (5)：
2019/04 - 現在 Chiba University Graduate School of Pharmaceutical Sciences
2018/11 - 2019/03 Chiba University Graduate School of Pharmaceutical Sciences
2013/11 - 2018/10 Chiba University Graduate School of Pharmaceutical Sciences
2013/04 - 2013/10 Pharmaceuticals and Medical Devices Agency
2011/04 - 2013/03 日本学術振興会 特別研究員(DC2)
Committee career (4)：
2022/10 - 現在 日本免疫毒性学会 連携学会委員
2022/10 - 現在 日本免疫毒性学会 学術編集委員
2022/07 - 現在 日本毒性学会 評議員
2019/10 - 現在 日本免疫毒性学会 評議員
Awards (8)：
2023/03 - The Pharmaceutical Society of Japan Award for Young Scientists Elucidation of mechanism underlying individual differences in adverse drug reactions
2021/11 - 日本薬物動態学会 第36回年会 ベストポスター賞 Elimination of Immunosuppressive Factors Clearly Exhibits Idiosyncratic Toxicity by Abacavir in HLA-B*57:01-Transgenic Mice
2020/06 - Biol.Pharm.Bull. Highlighted paper selected by Editor-in-Chief Detection of abacavir-induced structural alterations in human leukocyte antigen-B*57:01 using phage display
THE JAPANESE SOCIETY FOR THE STUDY OF XENOBIOTICS
, THE MOLECULAR BIOLOGY SOCIETY OF JAPAN
, THE JAPANESE SOCIETY OF TOXICOLOGY
, 日本免疫毒性学会
, THE JAPANESE CANCER ASSOCIATION
, THE PHARMACEUTICAL SOCIETY OF JAPAN
