KUBOTA Yasushi

クボタヤスシ | KUBOTA Yasushi

Research field (3)： Hematology and oncology , Developmental biology , Tumor diagnostics and therapeutics

Research keywords (7)： Hematology & Oncology , Leukemia , Hematopoietic stem cell , Leukemia stem cell , 環状オリゴ糖シクロデキストリン , フローサイトメトリー , オートファジー

Research theme for competitive and other funds (9)：

2020 - 2023 Development of new drugs and elucidation of immunity to cure all chronic myeloid leukemia patients
2020 - 2023 新規核酸医薬技術と葉酸修飾シクロデキストリンを用いる白血病治療法の開発
2017 - 2020 Exploring biomarkers concerning NK immunity that favor treatment discontinuation in CML patients
2016 - 2020 Development of a novel therapy targeting intracellular cholesterol for leukemia
2014 - 2017 MEK inhibitors selectively suppress GVHD while sparing antitumor and antiviral immunity after allogeneic hematopoietic stem cell transplantation

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Papers (103)：

Tomoe Anan, Yasuyuki Takahashi, Yuta Kimura, Takayuki Tabayashi, Yasushi Kubota. Successful Treatment of Disseminated Nocardiosis by Rapid Identification of the Organism via Genetic Analysis in a Leukemia Patient Undergoing Allogeneic Hematopoietic Stem Cell Transplantation. Cureus. 2024. 16. 4. e58489
Tomoe Anan, Yasuyuki Takahashi, Yasushi Kubota, Takeaki Matsunaga, Kumi Hirata, Taisuke Kawada, Noriyuki Sakata, Ken Naganuma, Masahiro Kizaki, Takayuki Tabayashi. A case of;acute;myeloid leukemia requiring;endotracheal intubation due to airway stenosis caused by laryngeal edema early after pre-transplant conditioning regimen. Journal of Saitama Medical University. 2024. 50. 2. 57-60
久保田寧. 臨床検査専門医がコッソリ教える...検査のTips!(第83回) フローサイトメトリー細胞の形と連動させて考えよう!. レジデントノート. 2024. 25. 16. 2928-2929
Yasushi Kubota, Toshimi Hoshiko, Taishi Higashi, Keiichi Motoyama, Seiji Okada, Shinya Kimura. Folate-Appended Hydroxypropyl-β-Cyclodextrin Induces Autophagic Cell Death in Acute Myeloid Leukemia Cells. International Journal of Molecular Sciences. 2023. 24. 23. 16720-16720
Risa Koresawa-Shimizu, Ritsuro Suzuki, Yasufumi Uehara, Nobuhiro Hiramoto, Masashi Sawa, Takahiro Fukuda, Keisuke Kataoka, Yoshinobu Kanda, Tatsuo Oyake, Yasushi Kubota, et al. Comparison of MEAM, MCEC and LEED high-dose chemotherapy followed by autologous stem cell transplantation in relapsed/refractory diffuse large B-cell lymphoma: data from the Japan Society for Hematopoietic and Cellular Therapy Registry. Bone marrow transplantation. 2023

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MISC (126)：

久保田寧. 臨床検査専門医がコッソリ教える...検査のTips!(第83回) フローサイトメトリー細胞の形と連動させて考えよう!. レジデントノート. 2024. 25. 16. 2928-2929
川田泰輔, 高橋康之, 平田公美, 坂田憲幸, 吉田澪奈, 永沼謙, 阿南朋恵, 久保田寧, 多林孝之, 百瀬修二, et al. MGRSから多発性骨髄腫へと進展したFanconi症候群に伴う低リン性骨軟化症. 臨床血液. 2023. 64. 10. 1344-1344
高橋康之, 松永洸昂, 平田公美, 坂田憲幸, 川田泰輔, 永沼謙, 阿南朋恵, 久保田寧, 木崎昌弘, 田丸淳一, et al. IgG型リンパ形質細胞性リンパ腫に続発した全身性アミロイドーシス. 日本血液学会学術集会. 2023. 85回. 302-302
坂田憲幸, 平田公美, 松永洸昂, 永沼謙, 高橋康之, 阿南朋恵, 久保田寧, 木崎昌弘, 多林孝之. クリプトコッカス髄膜炎を合併するも、イブルチニブ治療を継続できた慢性リンパ性白血病. 日本血液学会学術集会. 2023. 85回. 620-620
松永洸昂, 永沼謙, 平田公美, 坂田憲幸, 川田泰輔, 高橋康之, 阿南朋恵, 久保田寧, 木崎昌弘, 百瀬修二, et al. 再発時にmyeloperoxidaseを発現したearly T precursor lymphoblastic leukemia/lymphoma. 日本血液学会学術集会. 2023. 85回. 981-981

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Books (9)：

EBM 血液疾患の治療 2023-2024 edition
中外医学社 2022
1.総論-検査の選び方・進め方 1.血液一般検査 c)凝固・線溶異常(凝固異常症の鑑別,凝固亢進型と線溶亢進型の評価と意義)
2015
1.総論-検査の選び方・進め方 1.血液一般検査 c)凝固・線溶異常(凝固異常症の鑑別,凝固亢進型と線溶亢進型の評価と意義)
2015
Regulators of the Proliferation of Hematopoietic Stem and Progenitor Cells During Hematopoietic Regeneration.
InTech 2013
Regulators of the Proliferation of Hematopoietic Stem and Progenitor Cells During Hematopoietic Regeneration.
InTech 2013

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Lectures and oral presentations (92)：

An unusual progression of DLBCL accompanied by abundant T cell infiltrations and composite of AITL.
(第83回日本血液学会学術集会.(完全Web開催) 2021)
Two distinct presentation mode of PRCA with thymic hyperplasia, hypogammaglobulinemia and ATL.
(第83回日本血液学会学術集会.(完全Web開催) 2021)
First, second, and third attempts at TKI discontinuation in patients with CML.
(第83回日本血液学会学術集会.(完全Web開催) 2021)
The clinical importance of DNMT3A, NPM1, and FLT3-ITD triple-mutation in Japanese AML.
(第83回日本血液学会学術集会.(完全Web開催) 2021)
A late relapse of acquired TTP after rituximab therapy falsely negative for ADAMTS13 inhibitor.
(第83回日本血液学会学術集会.(完全Web開催) 2021)

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Education (2)：

2003 - 2007 Kyoto University Graduate School of Medicine
1991 - 1997 Saga Medical School Faculty of Medicine

Professional career (1)：

医学博士 (京都大学)

Work history (5)：

2024/04 - 現在 Saga-Ken Medical Centre KOSEIKAN Department of Clinical Laboratory Medicine Department Head
2021/07 - 2024/03 Saitama Medical University, Saitama Medical Center Department of Transfusion Medicine and Cell Therapy Professor
2012/10 - 2021/06 Saga University, Faculty of Medicine Division of Hematology, Respiratory Medicine and Oncology, Department of Internal Medicine Lecturer
2010/04 - 2012/09 Saga University, Faculty of Medicine Division of Hematology, Respiratory Medicine and Oncology, Department of Internal Medicine Assistant professor
2007/04 - 2010/03 RIKEN Center for Developmental Biology Laboratory for Stem Cell Biology Research Associate

Committee career (4)：

2024/03 - 現在 Japanese Society for Transplantation and Cell Therapy Councilor
2022/09 - 現在 Japanese Society of Hematology COI committee
2019/09 - 現在 Japanese Society of Hematology Councilor
2017/04 - 現在 Japanese Society of Tansfusion and Cell Therapy Councilor

Awards (3)：

2016/11 - 日本白血病研究基金一般研究賞
2010/06 - European Hematology Association 15th EHA Congress Travel Award Identification of long-term hematopoietic stem cell without negative selection
2007/10 - Japanese Society of Hematology 69th JSH congress Best Poster Award

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