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J-GLOBAL ID:201901003238038248   Update date: Feb. 07, 2025

Yokoyama Takeshi

ヨコヤマ タケシ | Yokoyama Takeshi
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Affiliation and department:
Other affiliations (5):
  • Tohoku University  Advanced Research Center for Innovations in Next-Generation Medicine 
  • Tohoku University  Faculty of Agriculture Department of Applied Biological Chemistry 
  • Tohoku University
  • Tohoku University  Frontier Research Institute for Interdisciplinary Sciences 
  • Japan Science and Technology Agency
Homepage URL  (1): https://yokotakehome.com
Research field  (2): Structural biochemistry ,  Molecular biology
Research keywords  (6): ribosome ,  cryo-electron microscopy ,  single particle analysis ,  translation ,  RNA ,  macromolecular assembly
Research theme for competitive and other funds  (13):
  • 2024 - 2026 新規作用機序によりリボソームの翻訳課程を阻害する抗グラム陰性菌薬リードの創製
  • 2023 - 2026 分泌経路におけるメゾスケール構造体プロファイリングの開拓
  • 2024 - 2025 革新的配糖化技術を基盤とした肺非結核性抗酸菌(NTM)症に対する新規抗菌物質の創製
  • 2022 - 2024 マグネシウム結合によるリボソーム活性制御の構造基盤
  • 2021 - 2024 細菌の細胞分裂におけるFtsZ繊維化機構の解明
Show all
Papers (34):
  • Wijak Yospanya, Akari Matsumura, Yukihiro Imasato, Tomoyuki Itou, Yusuke Aoki, Hikaru Nakazawa, Takashi Matsui, Takeshi Yokoyama, Mihoko Ui, Mitsuo Umetsu, et al. Design of Cyborg Proteins by Loop Region Replacement with Oligo(ethylene glycol): Exploring Suitable Mutations for Cyborg Protein Construction Using Machine Learning. Bulletin of the Chemical Society of Japan. 2024
  • Isaac Carilo, Yosuke Senju, Takeshi Yokoyama, Robert C. Robinson. Inter-compatibility of eukaryotic and Asgard archaea ribosome-translocon machineries. Journal of Biological Chemistry. 2024. 107673-107673
  • Risa Asano, Miyu Takeuchi, Makoto Nakakido, Sho Ito, Chihiro Aikawa, Takeshi Yokoyama, Akinobu Senoo, Go Ueno, Satoru Nagatoishi, Yoshikazu Tanaka, et al. Characterization of a novel format scFv×VHH single-chain biparatopic antibody against metal binding protein MtsA. Protein Science. 2024. 33. 6
  • Momoka Ookubo, Yuka Tashiro, Kosuke Asano, Yoshiharu Kamei, Yoshikazu Tanaka, Takayuki Honda, Takeshi Yokoyama, Michiyo Honda. "Rich arginine and strong positive charge" antimicrobial protein protamine: From its action on cell membranes to inhibition of bacterial vital functions. Biochimica et biophysica acta. Biomembranes. 2024. 1866. 5. 184323-184323
  • Kunanon Chattrairat, Akira Yokoi, Min Zhang, Mikiko Iida, Kosuke Yoshida, Masami Kitagawa, Ayuka Niwa, Masatoshi Maeki, Takeshi Hasegawa, Takeshi Yokoyama, et al. Discrimination of extracellular miRNA sources for the identification of tumor-related functions based on nanowire thermofluidics. Device. 2024. 100363-100363
more...
Books (9):
  • 実験医学 42(9)「ホウ素による翻訳制御の新しいしくみ-80SリボソームがmRNA上を滑って移動する」
    羊土社 2024
  • 高分子 72(8)「クライオ電子顕微鏡で生体高分子を観る」
    2023
  • 「クライオ電子顕微鏡ハンドブック」第4章14節 クライオ電子顕微鏡で見る、リボソームの「かたち」と「動き」
    NTS 2023
  • 顕微鏡 57(3)「透過型電子顕微鏡によるリボソームの構造解析、その歴史と今」
    2023
  • Single particle cryo-EM of ribosomal complexes: visualization of how ribosome works in translation
    2022
more...
Lectures and oral presentations  (63):
  • Sample Preparation
    (Cryo-electron Microscopy Course at OIST 2025)
  • クライオ電子顕微鏡入門編
    (第3回 東北大学INGEMクライオ電顕コース 2025)
  • Direct visualization of antibiotic action on translating ribosomes in the molecular crowding cell-free environments
    (NEXUS Thailand-Japan Bilateral Research Exchange Symposium 2025)
  • The DARC method: クライオ電子顕微鏡で分子夾雑環境下のリボソームの動態を直接可視化する
    (大阪大学蛋白質研究所セミナー、リボソーム・翻訳システムをハックする 2024)
  • Direct visualization of antibiotic action on the ribosome in a molecular crowding cell-free translation system
    (Ribosome Meeting 2024 in Japan 2024)
more...
Professional career (1):
  • 博士(工学) (東京大学)
Committee career (6):
  • 2024/11 - 現在 日本顕微鏡学会・電子顕微鏡大学 講師
  • 2023/04 - 現在 日本顕微鏡学会・和文誌「顕微鏡」 編集委員
  • 2020/04 - 現在 日本顕微鏡学会・若手研究部会 幹事
  • 2020/04 - 現在 日本顕微鏡学会・微生物顕微鏡解析分科会 幹事
  • 2021/04 - 2023/03 日本顕微鏡学会・和文誌「顕微鏡」 幹事
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Awards (2):
  • 2018/03 - RIKEN Center for Life Science Technologies CLST Researcher Incentive Award Structural analysis of various protein/ protein complexes by Cryo-EM
  • 2018/03 - RIKEN RIKEN Research Incentive Award Structural analysis of various proteins/ protein complexes by Cryo-EM
Association Membership(s) (6):
日本農芸化学会 ,  日本生物物理学会 ,  日本蛋白質科学会 ,  日本分子生物学会 ,  THE RNA SOCIETY OF JAPAN ,  THE JAPANESE SOCIETY OF MICROSCOPY
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