Rchr
J-GLOBAL ID:201901003776575164
Update date: Oct. 18, 2023
Nakamura Hitomi
Nakamura Hitomi
Affiliation and department:
Job title:
Lecturer
Homepage URL (1):
http://www.ph.sojo-u.ac.jp/~nakamura/homepage/index.html
Research field (2):
Clinical pharmacy
, Pharmaceuticals - analytical and physicochemistry
Research keywords (3):
蛋白質工学
, 分子生物学
, 生化学
Research theme for competitive and other funds (7):
Papers (13):
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Moeka Yoshikawa, Hitomi Nakamura, Naoko Oda-Ueda, Takatoshi Ohkuri. Analysis of thermostability for seven Phe to Ala and six Pro to Gly mutants in the Fab constant region of adalimumab. J. Biochem. 2023. 174. 4. 345-353
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Yoshikawa M, Nakamura H, Oda-Ueda N, Ueda T, Ohkuri T. Effect of an intermolecular disulfide bond introduced into the first loop of CH1 domain of Adalimumab Fab on thermal stability and antigen-binding activity. J. Biochem. 2022. 172. 1. 49-56
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Hitomi Nakamura, Masato Kiyoshi, Makoto Anraku, Noritaka Hashii, Naoko Oda-Ueda, Tadashi Ueda, Takatoshi Ohkuri. Glycosylation decreases aggregation and immunogenicity of adalimumab Fab secreted from Pichia pastoris. J. Biochem. 2021. 169. 4. 435-443
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Hitomi Nakamura, Moeka Yoshikawa, Naoko Oda-Ueda, Tadashi Ueda, Takatoshi Ohkuri. A comprehensive analysis of novel disulfide bond introduction site into the constant domain of human Fab. Sci. Rep. 2021. 11. 1. 12937
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Nakamura H, Anraku M, Oda-Ueda N, Ueda T, Ohkuri T. C-terminal cysteine PEGylation of adalimumab Fab with an engineered interchain SS bond. Biol. Pharm. Bull. 2020. 43. 3. 418-423
more...
Lectures and oral presentations (41):
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抗体医薬アダリムマブFabの可変-定常ドメイン間へのSS結合導入による熱安定性の上昇
(第23回日本蛋白質科学会年会 2023)
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セルトリズマブFab可変領域へのアミノ酸変異導入による安定化
(日本薬学会第143年会 2023)
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抗体医薬アダリムマブFabの定常領域における7種のPhe→Ala変異体及びPhe-Pro配列上の6種のPro→Gly変異体の熱安定性解析
(第22回日本蛋白質科学会年会 2022)
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抗体医薬品Fabの酵母<I>Pichia pastoris</I>を用いた調製
(日本薬学会第142年会 2022)
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ジスルフィドスキャンによるアダリムマブFabの分子間SS結合導入部位のデザインと酵母による変異体の作製
(第94回日本生化学大会 2021)
more...
Education (3):
- 2012 - 2015 Kyushu University
- 2006 - 2008 Kyushu University
- 2002 - 2006 Kyushu University Faculty of Pharmaceutical Science
Professional career (1):
Work history (3):
- 2021/04 - 現在 Sojo University Faculty of Pharmaceutical Sciences Department of Pharmaceutical Sciences
- 2015/04 - 2021/03 Sojo University Faculty of Pharmaceutical Sciences Department of Pharmaceutical Sciences
- 2008/04 - 2015/03 Sojo University Faculty of Pharmaceutical Sciences Department of Pharmaceutical Sciences
Association Membership(s) (6):
日本抗体学会
, 日本薬学会
, 日本分子生物学会
, 日本蛋白質科学会
, 日本生化学会
, 毒素シンポジウム
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