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J-GLOBAL ID:201901005220531306   Update date: Jan. 06, 2025

Sekine Hiroki

セキネ ヒロキ | Sekine Hiroki
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Affiliation and department:
Research field  (1): Molecular biology
Research keywords  (4): 低酸素 ,  遺伝子発現 ,  翻訳後修飾 ,  転写因子
Research theme for competitive and other funds  (7):
  • 2023 - 2026 Elucidation of renoprotective effects by pharmacological intervention into oxygen metabolism, using living renal cells from urine of diabetic kidney disease patients
  • 2023 - 2026 新規酸素感知機構PNPO-PLPシステムによる生体内低酸素への応答・適応機構の解明
  • 2023 - 2026 認知症におけるオートファジー障害の病態解明とPADREによる超早期画像診断法の開発
  • 2022 - 2025 Therapeutic strategy against infectious and inflammatory diseases by targeting master regulators of mast cells and eosinophils
  • 2020 - 2023 O-GlcNAc修飾とその認識機構を介した生体恒常性維持機構の解析
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Papers (33):
  • Hiroki Sekine, Haruna Takeda, Norihiko Takeda, Akihiro Kishino, Hayato Anzawa, Takayuki Isagawa, Nao Ohta, Shohei Murakami, Hideya Iwaki, Nobufumi Kato, et al. Author Correction: PNPO-PLP axis senses prolonged hypoxia in macrophages by regulating lysosomal activity. Nature metabolism. 2024. 6. 12. 2391-2391
  • Takaaki Akaike, Masanobu Morita, Seiryo Ogata, Jun Yoshitake, Minkyung Jung, Hiroki Sekine, Hozumi Motohashi, Uladzimir Barayeu, Tetsuro Matsunaga. New aspects of redox signaling mediated by supersulfides in health and disease. Free radical biology & medicine. 2024. 222. 539-551
  • Hiroki Sekine, Haruna Takeda, Norihiko Takeda, Akihiro Kishino, Hayato Anzawa, Takayuki Isagawa, Nao Ohta, Shohei Murakami, Hideya Iwaki, Nobufumi Kato, et al. PNPO-PLP axis senses prolonged hypoxia in macrophages by regulating lysosomal activity. Nature metabolism. 2024
  • Norio Suzuki, Yuma Iwamura, Koichiro Kato, Hirotaka Ishioka, Yusuke Konta, Koji Sato, Nao Uchida, Noa Koida, Hiroki Sekine, Tetsuhiro Tanaka, et al. Crosstalk between oxygen signaling and iron metabolism in renal interstitial fibroblasts. Journal of clinical biochemistry and nutrition. 2024. 74. 3. 179-184
  • Hayasaka K, Ohkouchi S, Saito-Koyama R, Suzuki Y, Okazaki K, Sekine H, Watanabe T, Motohashi H, Okada Y. Aging Exacerbates Murine Lung Ischemia-Reperfusion Injury by Excessive Inflammation and Impaired Tissue Repair Response. American Journal of Transplantation. 2023. S1600-6135
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MISC (9):
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Lectures and oral presentations  (15):
  • 慢性低酸素における超硫黄分子制御
    (フォーラム2024衛生薬学・環境トキシコロジー 2024)
  • 酸素依存性代謝物がもたらす細胞の応答機構
    (第32回日本Cell Death学会学術集会 2024)
  • 慢性低酸素による代謝変換を介した炎症制御機構
    (第45回日本炎症・再生医学会. 2024)
  • 酸素感知代謝物としてのビタミンB6の機能
    (第76回日本ビタミン学会 2024)
  • PNPO-PLPシステムによる低酸素感知機構.
    (第46回日本分子生物学会年会. 2023)
more...
Professional career (1):
  • Ph.D (University of Tsukuba)
Association Membership(s) (3):
日本ビタミン学会 ,  日本酸化ストレス学会 ,  THE JAPANESE BIOCHEMICAL SOCIETY
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