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J-GLOBAL ID：201901005281360113 Update date: Apr. 11, 2025

Takashima Ippei

タカシマイッペイ | Takashima Ippei

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Affiliation and department：
Job title： Associate Professor
Homepage URL (1)： https://www.hakodatekosen.com/

Research field (3)： Chemical biology , Pharmaceuticals - analytical and physicochemistry , Bioorganic chemistry

Research keywords (3)： Protein engineering , fluorescent probe , Chemical biology

Research theme for competitive and other funds (11)：

2023 - 2026 Development of fluorescent tools imaging the initial process of protein-droplet autophagy
2025 - 2026 AFM/EM imaging of intracellular metals with nanostructures constructed via signal amplification systems
2024 - 2025 シグナル増強システムを介したナノ構造形成による細胞内金属種のAFM/EMイメージング
2021 - 2025 シグナル増強システムを用いた亜鉛イオンの生体内蛍光イメージング
2023 - 2024 シグナル増強システムを介したナノ構造形成による細胞内金属種のAFM/EMイメージング

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Papers (24)：

Kensuke Okuda, Akira Takagi, Ryohei Shimizu, Kensuke Nishi, Narumi Hayano, Ippei Takashima, Morichika Konishi. Total Synthesis of Antiausterity Agent Callistrilone O Reveals Promising Antitumor Activity in a Melanoma Homograft Mouse Model. ChemMedChem. 2025. 20. 7
Akira Takagi, Ippei Takashima, Kensuke Okuda. A turn-on fluorescent probe containing a β-ketoester moiety for the selective detection of intracellular hydrazine. RSC Advances. 2025. 15. 1. 428-434
Akira Takagi, Kazuki Usuguchi, Ippei Takashima, Kensuke Okuda. Development of 1,3,6-Tribenzoylated Glucose as an Antiausterity Agent Targeting Tumor Microenvironment. Chemical and Pharmaceutical Bulletin. 2023. 71. 8. 641-649
Kensuke Okuda, Ippei Takashima, Akira Takagi. Advances in reaction-based synthetic fluorescent probes for studying the role of zinc and copper ions in living systems. Journal of Clinical Biochemistry and Nutrition. 2023. 72. 1. 1-12
Anna Kanegae, Yusuke Takata, Ippei Takashima, Shohei Uchinomiya, Ryosuke Kawagoe, Kazuteru Usui, Akira Yamashita, Jirarut Wongkongkatep, Manabu Sugimoto, Akio Ojida. A multicolor and ratiometric fluorescent sensing platform for metal ions based on arene-metal-ion contact. Communications Chemistry. 2021. 4. 1

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MISC (5)：

Development of a sensitive fluorescent probe detecting intracellular zinc through zinc-catalyzed hydrolysis. Journal of Zinc Nutritional Therapy. 2021. 12. 1. 15-23
Ippei Takashima. 細胞治療を指向した自己集合性小分子による細胞表面修飾. Division of Biofunctional Chemistry the Chemical Society of Japan - News Letter. 2018. 33. 4-8
Takashima Ippei, Uesugi Motonari. Self-assembling compounds as an emerging class of bioactive small molecules. MEDCHEM NEWS. 2017. 27. 1. 9-13
Ippei Takashima. トピックス: サイクリン依存性キナーゼ選択的な共有結合型阻害剤の有用性. Farumasia. 2017. 53. 6. 587-587
Akio Ojida, Ippei Takashima. [Development of Fluorescence Sensing Mechanism for Cell Functional Analysis]. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan. 2016. 136. 1. 3-7

Patents (3)：

Novel compound and the derivatives as fluorescent probes to detect zinc ion
COMPOUND FOR IMPROVIN CELL TRANSPLANTATION EFFICIENCY
プリプレグおよびその製造方法、繊維強化樹脂成形体

Books (1)：

Controlling Biomolecular Reactions
2020 ISBN:9784759813968

Lectures and oral presentations (31)：

Fluorescence imaging of initiation process in autophagy of protein condensates
(The 105th CSJ Annual Meeting 2025)
AFM/EM imaging of intracellular metals with nanostructures constructed via signal amplification systems
(The 15th International Symposium of Advanced Energy Science 2024)
タンパク質複合体のin situ 構築による細胞内分子の電顕可視化
(第18回バイオ関連化学シンポジウム 2024)
New molecular design of cyclic tetrazine with the tuned reactivity for inverse electron-demand Diels-Alder reaction
(The 17th Symposium on Biorelevant Chemistry 2023)
Development of a protein assembling system for unique structural tags in EM-imaging
(The 3rd meeting, New cross-scale biology, Grant-in-Aid for Transformative Research Areas (A) 2023)

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Education (3)：

2011 - 2015 Kyushu University Graduate school of pharmacy Department of pharmaceutical science
2006 - 2008 Kyoto University Graduate school of engineering Department of synthetic chemistry and biological chemistry
2002 - 2006 Kyoto University Faculty of engineering Industrial chemistry

Professional career (1)：

博士(薬学) (九州大学)

Work history (5)：

2022/04 - 2025/03 Tohoku University Institute of Multidisciplinary Research for Advanced Materials Assistant professor
2019/04 - 2022/03 Kobe Pharmaceutical University
2018/04 - 2019/03 North Carolina state University Chemistry Post-Doc
2015/02 - 2018/03 Kyoto University Institute for chemical research Post-Doc
2008/04 - 2011/03 Toray Industries, Inc. Engineering department of Prepreg Engineer

Awards (7)：

2021/08 - 第22回日本亜鉛栄養治療研究会学術集会基礎領域優秀演題賞
2021/02 - 令和2年度コニカミノルタ画像科学奨励賞
2018/03 - 日本化学会第98春季年会優秀講演賞(学術)
2015/03 - 日本薬学会第135年会優秀発表賞
2012/10 - 第3期大津会議アワードフェロー

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Association Membership(s) (4)：

Division of Biofunctional Chemistry, The Chemical Society of Japan , JAPANESE SOCIETY FOR CHEMICAL BIOLOGY , THE PHARMACEUTICAL SOCIETY OF JAPAN , THE CHEMICAL SOCIETY OF JAPAN

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