Research field (3)：
Chemical biology
, Pharmaceuticals - analytical and physicochemistry
, Bioorganic chemistry
Research keywords (3)：
Protein engineering
, fluorescent probe
, Chemical biology
Research theme for competitive and other funds (6)：
2021 - 2023 酵素変異体-蛍光基質による2価マンガンのシグナル増強型検出法
2021 - 2022 Fluorescenct analyses of biomolecules and metals using cephem compounds
2019 - 2021 Development of fluorescent probes with AND-logic gate response for HYPOXIA
2020 - 2021 酵素-抗体複合体による細胞表面マーカーの発現量解析
2016 - 2018 移植細胞の生着効率を高める合成化合物の創製
2012 - 2013 アセチルCoAを選択的に検出する蛍光プローブを用いた細胞内代謝の可視化解析
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Papers (22)：
Akira Takagi, Kazuki Usuguchi, Ippei Takashima, Kensuke Okuda. Development of 1,3,6-Tribenzoylated Glucose as an Antiausterity Agent Targeting Tumor Microenvironment. Chemical and Pharmaceutical Bulletin. 2023. 71. 8. 641-649
Kensuke Okuda, Ippei Takashima, Akira Takagi. Advances in reaction-based synthetic fluorescent probes for studying the role of zinc and copper ions in living systems. Journal of Clinical Biochemistry and Nutrition. 2023. 72. 1. 1-12
Anna Kanegae, Yusuke Takata, Ippei Takashima, Shohei Uchinomiya, Ryosuke Kawagoe, Kazuteru Usui, Akira Yamashita, Jirarut Wongkongkatep, Manabu Sugimoto, Akio Ojida. A multicolor and ratiometric fluorescent sensing platform for metal ions based on arene-metal-ion contact. Communications Chemistry. 2021. 4. 1
Akira Takagi, Kazuki Usuguchi, Ippei Takashima, Kensuke Okuda. Total Synthesis of Antiausterity Agent (±)-Uvaridacol L by Regioselective Axial Diacylation of a myo-Inositol Orthoester. Organic Letters. 2021. 23. 11. 4083-4087
Shuyu Jin, Hue Thi Vu, Kou Hioki, Naotaka Noda, Hiroki Yoshida, Toru Shimane, Shigenari Ishizuka, Ippei Takashima, Yoshiyuki Mizuhata, Kathleen Beverly Pe, et al. Discovery of Self-Assembling Small Molecules as Vaccine Adjuvants. Angewandte Chemie. 2021. 133. 2. 974-982
Akio Ojida, Ippei Takashima. [Development of Fluorescence Sensing Mechanism for Cell Functional Analysis]. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan. 2016. 136. 1. 3-7
Patents (3)：
Novel compound and the derivatives as fluorescent probes to detect zinc ion
COMPOUND FOR IMPROVIN CELL TRANSPLANTATION EFFICIENCY
New molecular design of cyclic tetrazine with the tuned reactivity for inverse electron-demand Diels-Alder reaction
(The 17th Symposium on Biorelevant Chemistry 2023)
Development of a protein assembling system for unique structural tags in EM-imaging
(The 3rd meeting, New cross-scale biology, Grant-in-Aid for Transformative Research Areas (A) 2023)
AFM/EM imaging of intracellular metals with nanostructures constructed via signal amplification systems
(The 14th International Symposium of Advanced Energy Science 2023)
2011 - 2015 Kyushu University Graduate school of pharmacy Department of pharmaceutical science
2006 - 2008 Kyoto University Graduate school of engineering Department of synthetic chemistry and biological chemistry
2002 - 2006 Kyoto University Faculty of engineering Industrial chemistry
Professional career (1)：
博士(薬学) (九州大学)
Work history (4)：
2019/04 - 2022/03 Kobe Pharmaceutical University
2018/04 - 2019/03 North Carolina state University Chemistry Post-Doc
2015/02 - 2018/03 Kyoto University Institute for chemical research Post-Doc
2008/04 - 2011/03 Toray Industries, Inc. Engineering department of Prepreg Engineer
Awards (7)：
2021/02 - 令和2年度コニカミノルタ画像科学奨励賞
2018/03 - 日本化学会第98春季年会 優秀講演賞(学術)
2015/03 - 日本薬学会第135年会 優秀発表賞
2012/10 - 第3期大津会議アワードフェロー
2011/07 - 第48回化学関連支部合同九州大会 九州分析化学ポスター賞
2011/07 - 第23回生体機能関連化学部会若手の会夏季セミナー 優秀ポスター賞
2011/05 - 第21回 万有福岡シンポジウム ベストポスター賞
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Association Membership(s) (4)：
THE CHEMICAL SOCIETY OF JAPAN
, Division of Biofunctional Chemistry, The Chemical Society of Japan
, JAPANESE SOCIETY FOR CHEMICAL BIOLOGY
, THE PHARMACEUTICAL SOCIETY OF JAPAN
