Ueki Ryosuke

Affiliation and department：
Job title：助教
Homepage URL (1)： http://park.itc.u-tokyo.ac.jp/sandolab/Ueki_Ryosuke.html

Research field (2)： Biomedical engineering , Applied biofunctional and bioprocess engineering

Research keywords (7)：増殖因子/サイトカイン , シグナル伝達 , 再生医療 , 分子進化工学 , 受容体アゴニスト , 核酸アプタマー , 核酸化学

Research theme for competitive and other funds (9)：

2020 - 2023 細胞培養に向けた人工細胞増殖因子
2020 - 2023 In silicoデザインで実現する受容体アゴニストの精密活性制御
2019 - 2021 DNA-based mimetics of growth factors to reveal molecular mechanisms underlying partial agonism
2017 - 2019 Regulation of cell differentiation signal with oligonucleotide-based growth factor mimetics
2015 - 2017 Kinetic analysis of the activation process of receptor tyrosine kinases by using DNA aptamer

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Papers (24)：

Hanrui Liu, Toni A Baeumler, Kai Nakamura, Yuga Okada, Seojung Cho, Akihiro Eguchi, Daisuke Kuroda, Kouhei Tsumoto, Ryosuke Ueki, Shinsuke Sando. An Engineered Synthetic Receptor-Aptamer Pair for an Artificial Signal Transduction System. ACS nano. 2023. 17. 10. 9039-9048
Yuki Hosono, Satoshi Uchida, Moe Shinkai, Chad E Townsend, Colin N Kelly, Matthew R Naylor, Hsiau-Wei Lee, Kayoko Kanamitsu, Mayumi Ishii, Ryosuke Ueki, et al. Amide-to-ester substitution as a stable alternative to N-methylation for increasing membrane permeability in cyclic peptides. Nature communications. 2023. 14. 1. 1416-1416
Junya Hoshiyama, Yuga Okada, Seojung Cho, Ryosuke Ueki, Shinsuke Sando. Apt-clean: Aptamer-mediated cleavage of extracellular antigen for the inhibition of membrane protein functions. Biomaterials Science. 2022
Ryosuke Ueki, Yuma Watanabe, Momoko Akiyama, Esther Darley, Shinsuke Sando. CiD agonists: Circular DNA-based agonists for the fine-tuning of receptor signaling. ChemRxiv. 2022
戴以周, 中道曉子, 植木亮介, 山東信介, 長谷川潔, 伊藤大知. 肝細胞増殖因子DNA aptamerによる術後腹膜癒着の予防(Prevention of Postoperative Peritoneal Adhesion by Hepatocyte Growth Factor DNA Aptamer). 日本DDS学会学術集会プログラム予稿集. 2022. 38回. 115-115

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Patents (4)：

Books (9)：

Handbook of Chemical Biology of Nucleic Acids
Springer 2022 ISBN:9789811613135
核酸医薬 : 本領を発揮する創薬モダリティ : 新たな作用機序を生む核酸のサイエンスから、新薬・ワクチン承認をもたらした核酸修飾・DDS技術、難治性疾患治療への挑戦まで
羊土社 2021 ISBN:9784758103985
BIO Clinica 2021年 12月号核酸医薬の現状と今後の展望
2021
進化を続ける核酸化学:ゲノム編集,非二重らせん,核酸医薬 (CSJ カレントレビュー)
化学同人 2021 ISBN:4759814019
The Chemical Times 2020 Vol.2
2020

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Lectures and oral presentations (17)：

A novel strategy for the selective inhibition of membrane protein functions with DNA aptamers
(The 49th International Symposium on Nucleic Acids Chemistry 2022)
機能性DNAに基づく増殖因子ミメティクスの開発とケミカルツール応用
(日本化学会第102春季年会 2022)
Aptamer-based mimetic of growth factors for precise control of cellular functions and fates
(Pacifichem 2021 2021)
アプタマーによる受容体シグナル操作の最前線
(第44回分子生物学会年会 2021)
DNA aptamer-based chemical tools for the control of receptor functions
(第2回 Aptamer Seminar in Tokyo 2021)

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Education (2)：

Professional career (1)：

Work history (3)：

Awards (4)：

Association Membership(s) (2)：

日本化学会 , 日本核酸化学会

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