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J-GLOBAL ID：201901006034021981 Update date: Mar. 29, 2025

Ueki Ryosuke

Affiliation and department：
Job title：助教
Homepage URL (1)： http://park.itc.u-tokyo.ac.jp/sandolab/Ueki_Ryosuke.html

Research field (2)： Biomedical engineering , Applied biofunctional and bioprocess engineering

Research keywords (7)：増殖因子/サイトカイン , シグナル伝達 , 再生医療 , 分子進化工学 , 受容体アゴニスト , 核酸アプタマー , 核酸化学

Research theme for competitive and other funds (9)：

2020 - 2023 細胞培養に向けた人工細胞増殖因子
2020 - 2023 In silicoデザインで実現する受容体アゴニストの精密活性制御
2019 - 2021 DNA-based mimetics of growth factors to reveal molecular mechanisms underlying partial agonism
2017 - 2019 Regulation of cell differentiation signal with oligonucleotide-based growth factor mimetics
2015 - 2017 Kinetic analysis of the activation process of receptor tyrosine kinases by using DNA aptamer

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Papers (30)：

Masahiro Wakano, Masaya Tsunoda, Keiji Murayama, Jumpei Morimoto, Ryosuke Ueki, Saeko Aoyama-Ishiwatari, Yusuke Hirabayashi, Hiroyuki Asanuma, Shinsuke Sando. Reversible Optical Control of Receptor Tyrosine Kinase Activity and ERK Dynamics Using Azobenzene-Carrying DNA Aptamer Agonist. Journal of the American Chemical Society. 2025
Yichen Gong, Song Tu, Ryosuke Ueki, Yoshihisa Fujii, Shintaro Yasuda, Shinsuke Sando, Junya Uchida, Kazuki Fukushima, Takashi Kato. Liquid-Crystalline Block Copolymers Comprising Cholesterol-Based Dendritic Moieties and Poly(L,L-lactide) Chains. ACS Applied Polymer Materials. 2025. 7. 3. 1875-1885
Yizhou Dai, Natsuko F Inagaki, Ryosuke Ueki, Shinsuke Sando, Kiyoshi Hasegawa, Taichi Ito. Hepatocyte Growth Factor DNA Aptamer for Prevention of Postoperative Peritoneal Adhesion via Enhancement of Fibrinolysis and Inhibition of Mesothelial Mesenchymal Transition. ACS applied bio materials. 2024. 7. 7. 4679-4689
Yuyuan Chen, Kunihiko Morihiro, Yui Nemoto, Akito Ichimura, Ryosuke Ueki, Shinsuke Sando, Akimitsu Okamoto. Selective inhibition of cancer cell migration using a pH-responsive nucleobase-modified DNA aptamer. Chemical Science. 2024. 15. 41. 17097-17102
Junya Hoshiyama, Yuri Hayata, Akihiro Eguchi, Jumpei Morimoto, Ryosuke Ueki, Shinsuke Sando. Analysis of cell signaling profiles induced by DNA aptamer-based FGFR1 agonist. Analytical Sciences. 2024

Patents (4)：

Books (9)：

Handbook of Chemical Biology of Nucleic Acids
Springer 2022 ISBN:9789811613135
核酸医薬 : 本領を発揮する創薬モダリティ : 新たな作用機序を生む核酸のサイエンスから、新薬・ワクチン承認をもたらした核酸修飾・DDS技術、難治性疾患治療への挑戦まで
羊土社 2021 ISBN:9784758103985
BIO Clinica 2021年 12月号核酸医薬の現状と今後の展望
2021
進化を続ける核酸化学:ゲノム編集,非二重らせん,核酸医薬 (CSJ カレントレビュー)
化学同人 2021 ISBN:4759814019
The Chemical Times 2020 Vol.2
2020

Lectures and oral presentations (17)：

A novel strategy for the selective inhibition of membrane protein functions with DNA aptamers
(The 49th International Symposium on Nucleic Acids Chemistry 2022)
機能性DNAに基づく増殖因子ミメティクスの開発とケミカルツール応用
(日本化学会第102春季年会 2022)
Aptamer-based mimetic of growth factors for precise control of cellular functions and fates
(Pacifichem 2021 2021)
アプタマーによる受容体シグナル操作の最前線
(第44回分子生物学会年会 2021)
DNA aptamer-based chemical tools for the control of receptor functions
(第2回 Aptamer Seminar in Tokyo 2021)

Education (2)：

Professional career (1)：

Work history (3)：

Awards (4)：

Association Membership(s) (2)：

日本化学会 , 日本核酸化学会

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