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J-GLOBAL ID：201901006607392297 Update date: Jan. 07, 2025

HAMADA Nobushiro

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Research theme for competitive and other funds (35)：

2024 - 2028 Biofilm Disruption Using Sonodynamic Therapy
2023 - 2027 加齢に伴う歯周病の進行に対する歯肉マッサージの効果の解析
2022 - 2026 難治性カンジダ症に対する赤外自由電子レーザーを用いた新規治療法の開発
2022 - 2025 The proposal of using nicotianamine as a novel therapeutic agent in periodontal disease
2019 - 2022 歯周炎発症カニクイザルを用いた病原細菌の特定と細菌伝播経路の解明

2019 - 2022 The development of a new preventive method for periodontitis by immune regulation

2018 - 2022 循環器疾患を有する患者の歯周病治療戦略-抗酸化物質クルクミンの効果の基礎的解析

2018 - 2021 Use of a mid-infrared free-electron laser to treat infectious diseases: Its bactericidal effects against gram-negative bacteria

2016 - 2019 Basic study on efficacy of root canal irrigation using hard tissue decomposition abilit

2016 - 2019 Development and application of root caries model using polymicrobial biofilm

2016 - 2019 The mechanism of plant-derived polyphenols in the prevention of periodontal diseases

2015 - 2018 Roles of Jixueteng in therapeutic agents for periodontitis

2014 - 2018 Antioxidant activity of curcumin: Porphyromonas gingivalis infection modifies oral microcirculation and aortic vascular function in the stroke-prone spontaneously hypertensive rat (SHRSP).

2014 - 2017 Study on the pathogenicity of dental biofilm by molecular genetic technics

2013 - 2017 The establishment of the noninvasive assessment method of diabetic angiopathy by the gingival microcirculation

2013 - 2016 Effects of dental materials containing multiple ions releasing filler against viabilities of oral biofilms

2012 - 2015 Roles of plant extracts in therapeutic and preventive agents for periodontitis

2011 - 2013 Oral Vascular Functions Are Altered in Periodontitis and/or Stroke Disease Model

2009 - 2011 A study for the adherence of pathogens for the periodontal disease to the dental materials and for the inhibition effect of specific antibodies to the bacteria

2008 - 2010 BASIC RESEARCH FOR EFFECT OF OXIDISED GALECTIN-1 ON PERIODONTAL DISEASE THROUGH MACROPHAGE

2007 - 2008 歯周病原菌の抗酸化ストレス機能による組織障害の誘導と心血管疾患の関連の解明

2005 - 2006 A drug development study for a periodontal disease : Biological properties of synthetic lipid A of Porphyromonas gingivalis lipopolysaccharide

2003 - 2004 A study of mechanism of adherence to the oral cavity in periodontopathic bacteria by animal model.

2001 - 2002 Intranasal immunization of mice with P. gingivalis fimbriae and recombinant cholera toxin B subunit induces strong mucosal and systemic immune responses

2000 - 2002 呼気ガス分析法の確立と歯科診断への応用

2000 - 2002 Genetic analysis of expression control of Porphyromonas gingivalis fimbriation

1999 - 2002 Establishment of Transformation System on Periodontopathic Bacteria and Analysis of Pathogenic Factors

2000 - 2001 歯周病原因子の不活化株作製とその役割の解明

1999 - 2001 Prevention and treatment of periodntal disease ; the developments of mucosal vaccination and protease inhibitor

1999 - 2000 Prevention and treatment of periodontal disease ; the application to basic research and drug development on mucosal vaccination

1998 - 1999 P.gingivalis短線毛の遺伝子クローニングとその機能に関する研究

1997 - 1999 Analysis of gene control of P. gingivalis using a newly developed host-vector system.

1996 - 1998 Molecular biological analysis of virulent factors on P. gingivalis related with periodontal disease

1993 - 1995 Comstruction of a physical and gene map of periodontpathic bacterial genome

1993 - 1993 Porphyromonas gingivalisの線毛遺伝子不活化株の作製と線毛機能の解明

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Papers (93)：

Kiyoshi Tomiyama, Kiyoko Watanabe, Junko Iizuka, Nobushiro Hamada, Yoshiharu Mukai. Effects of a Mouthrinse Containing Silver Nanoparticles on Polymicrobial Oral Biofilms. Oral health & preventive dentistry. 2024. 22. 567-572
Ting-Hsuan Wang, Kiyoko Watanabe, Koichiro Muromachi, Nobushiro Hamada, Nobuyuki Tani-Ishii. Carbon Nanotubes Induce Mineralization of Human Cementoblasts. Journal of Endodontics. 2024
Sangmin Lee, Hiroshi Haraga, Takenori Satoh, Noriko Mutoh, Kiyoko Watanabe, Nobushiro Hamada, Nobuyuki Tani-Ishii. Effect of periodontitis induced by Fusobacterium nucleatum on the microbiota of the gut and surrounding organs. Odontology. 2023
Jun Tamiya, Wakako Sakaguchi, Kimiko Nakagawa, Toshiharu Yamamoto, Juri Saruta, Nobuhisa Kubota, Akira Kawata, Iwao Hasegawa, Nobushiro Hamada, Keiichi Tsukinoki. Detection of SARS-CoV-2 and Its Related Factors on the Mucosal Epithelium of the Tongue. Acta histochemica et cytochemica. 2023. 56. 2. 29-37
Kiyoshi Tomiyama, Masato Ishizawa, Kiyoko Watanabe, Akira Kawata, Nobushiro Hamada, Yoshiharu Mukai. Antibacterial effects of surface pre-reacted glass-ionomer (S-PRG) filler eluate on polymicrobial biofilms. American journal of dentistry. 2023. 36. 2. 91-94

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MISC (382)：

坂口和歌子, 猿田樹理, 山本裕子, 浜田信城, 槻木恵一. 新型コロナウィルス感染症における舌粘膜の解析(Analysis of the tongue mucosa in COVID-19 infection). Journal of Oral Biosciences Supplement. 2022. 2022. 205-205
Wang Ting Hsuan, 渡辺清子, 浜田信城, 石井信之. 骨芽細胞分化におけるTGF-b/MAPKシグナル伝達の解析(Analysis of TGF-b/MAPK signaling in osteoblast differentiation). Journal of Oral Biosciences Supplement. 2022. 2022. 236-236
佐藤武則, 浜田信城, 半田慶介. 抗IL-17抗体による歯槽骨吸収抑制効果(Inhibitory effect of anti-Interleukin-17-recepter antibody on alveolar bone resorption). Journal of Oral Biosciences Supplement. 2022. 2022. 335-335
浜田信城, 稲葉啓太郎, 倉橋絢子. 口腔微生物叢と歯科用アクリルレジンの開発. 神奈川歯学. 2022. 57. 1. 71-76
富山潔, 渡辺清子, 浜田信城, 向井義晴. 銀ナノ粒子含有洗口剤の多菌種バイオフィルムに対する齲蝕原性抑制効果. 特定非営利活動法人日本歯科保存学会学術大会プログラムおよび講演抄録集. 2022. 156回. 21-21

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