Rchr
J-GLOBAL ID：201901007418123567
Update date: Sep. 27, 2024
Yagai Tomoki
Yagai Tomoki
Affiliation and department：
Job title：
Associate Professor/Lecturer
Research field (2)：
Molecular biology
, Pathobiochemistry
Research theme for competitive and other funds (6)：
Papers (19)：
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谷貝 知樹, 菅波 孝祥. 今月の特集 肥満と健康障害 肥満と健康障害 非アルコール性脂肪性肝疾患(NAFLD). 臨床検査. 2024. 68. 5. 614-618
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Tomoki Yagai, Takahisa Nakamura. Mechanistic insights into the peroxisome proliferator-activated receptor alpha as a transcriptional suppressor. Frontiers in medicine. 2022. 9. 1060244-1060244
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Daisuke Aibara, Shogo Takahashi, Tomoki Yagai, Donghwan Kim, Chad N Brocker, Moshe Levi, Kimihiko Matsusue, Frank J Gonzalez. Gene repression through epigenetic modulation by PPARA enhances hepatocellular proliferation. iScience. 2022. 25. 5. 104196-104196
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Shicheng Fan, Yue Gao, Aijuan Qu, Yiming Jiang, Hua Li, Guomin Xie, Xinpeng Yao, Xiao Yang, Shuguang Zhu, Tomoki Yagai, et al. YAP-TEAD mediates PPAR α-induced hepatomegaly and liver regeneration in mice. Hepatology (Baltimore, Md.). 2022. 75. 1. 74-88
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Tomoki Yagai, Tingting Yan, Yuhong Luo, Shogo Takahashi, Daisuke Aibara, Donghwan Kim, Chad N Brocker, Moshe Levi, Hozumi Motohashi, Frank J Gonzalez. Feedback repression of PPARα signaling by Let-7 microRNA. Cell reports. 2021. 36. 6. 109506-109506
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MISC (7)：
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谷貝 知樹, 菅波 孝祥. NAFLD/NASHにおけるPPARαが担う肝脂質代謝と脂肪毒性の分子基盤解析. 日本内分泌学会雑誌. 2024. 100. 1. 297-297
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谷貝知樹. 非アルコール性脂肪性肝炎における脂肪酸とエクソソームの作用機序の解析. 三島海雲記念財団研究報告書(CD-ROM). 2021. 58. 1-4
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谷貝知樹, BROCKER Chad, BROCKER Chad, KIM Donghwan, 高橋昌悟, 高橋昌悟, GAVRILOVA Oksana, GONZALEZ Frank. 肝脂質代謝に関わるPPARα-制御性microRNAの新規機能の解析. 肝細胞研究会プログラム・抄録集. 2019. 26th
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谷貝知樹, 松井理司, 原田憲一, 中沼安二, 稲垣冬樹, 西條栄子, 宮島篤, 田中稔. 胆管傷害および胆管癌におけるsterile alpha motif domain containing5の発現解析. 肝細胞研究会プログラム・抄録集. 2014. 21st. 3P-434
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谷貝知樹, 田中稔, 原田憲一, 中沼安二, 稲垣冬樹, 西條栄子, 宮島篤. 胆管傷害および胆管癌におけるsterile alpha motif domain containing5の発現解析. 日本生化学会大会(Web). 2013. 86th
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Lectures and oral presentations (3)：
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PPARα-SMPD3 axis regulates hepatic lipid accumulation and inflammation in NAFLD/NASH
(Joint Meeting of ASMB, HCS, and ASIP 2023)
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A novel role for a PPARα-regulated microRNA in the control of hepatic lipid metabolism
(Keystone Symposium - Integrated Pathways of Disease in NASH and NAFLD 2019)
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Semaphorin 3E secreted by damaged hepatocytes regulates the sinusoidal regeneration and liver fibrosis during mouse liver regeneration
(Keystone Symposium, Fibrosis: From Bench to Bedside 2013)
Education (2)：
- 2009 - 2014 University of Tokyo Graduate School of Science
- 2005 - 2009 Hokkaido University School of Fisheries Science Department of Marine Biological Science
Professional career (1)：
Work history (5)：
- 2023/01 - 現在 Nagoya University Research Institute of Environmental Medicine Associate Professor/Lecturer
- 2019/10 - 2022/12 Tohoku University Institute of Development, Aging and Cancer Assistant Professor
- 2014/10 - 2019/09 National Institutes of Health, National Cancer Institute Laboratory of Metabolism Postdoctoral Fellow
- 2017/01 - 2018/12 日本学術振興会海外特別研究員(NIH)
- 2014/04 - 2014/09 The University of Tokyo Institute of Molecular and Cellular Biosciences Project Researcher
Awards (6)：
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