2017 - 2020 Clarification of metastasis development mechanism in oral cancer stem cell
2017 - 2019 低酸素環境下における口腔癌のがん幹細胞に対する新規分子標的治療の開発
2014 - 2017 Mechanism of multidrug resistance caused after the treatment targeting CD44, and the strategy for overcoming the resistance in head and neck squamous cell carcinoma.
2014 - 2017 Mastery of treatment resisitant cancer stem cells in oral squamous cell carcinoma
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Papers (45):
Kuniko Kusama-Eguchi, Yuki Tokui, Ai Minoura, Yuta Yanai, Dai Hirose, Megumi Furukawa, Yasuhiro Kosuge, Motofumi Miura, Emika Ohkoshi, Mitsuko Makino, et al. 2(3H)-Dihydrofranolactone metabolites from Pleosporales sp. NUH322 as anti-amyotrophic lateral sclerosis drugs. Journal of natural medicines. 2024. 78. 1. 146-159
Koichi Murakami, Naoki Umemura, Makoto Adachi, Masahiro Motoki, Emika Ohkoshi. ABCG2, CD44 and SOX9 are increased with the acquisition of drug resistance and involved in cancer stem cell activities in head and neck squamous cell carcinoma cells. Experimental and therapeutic medicine. 2022. 24. 6. 722-722
Koji Wada, Masuo Goto, Emika Ohkoshi, Kuo-Hsiung Lee, Hiroshi Yamashita. Bioactivity inspired C19-diterpenoid alkaloids for overcoming multidrug-resistant cancer. Journal of natural medicines. 2022
Kunihiro Kajiura, Naoki Umemura, Emika Ohkoshi, Takahisa Ohta, Nobuo Kondoh, Satoshi Kawano. Shikonin induces odontoblastic differentiation of dental pulp stem cells via AKT-mTOR signaling in the presence of CD44. Connective tissue research. 2021. 1-9
Toshiyuki Nanbu, Naoki Umemura, Emika Ohkoshi, Kumi Nanbu, Hiroshi Sakagami, Jun Shimada. Combined SN-38 and gefitinib treatment promotes CD44 degradation in head and neck squamous cell carcinoma cells. Oncology reports. 2018. 39. 1. 367-375