Rchr
J-GLOBAL ID：201901007884984637
Update date: Jan. 31, 2024
Okada Ryo
Okada Ryo
Affiliation and department：
Research field (4)：
Medical biochemistry
, Clinical pharmacy
, Pharmacology
, Physiology
Research theme for competitive and other funds (2)：
- 2014 - 2017 Regulation of periodontal disease-related cognitive impairment by controlling microglial phenotype change
- 2012 - 2014 Analysis of relationship between periodontal tissue para-inflammation induced neuroinflammation and phagocytic activity regulation by circadian cloclk system
Papers (12)：
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Masayuki X. Mori, Ryo Okada, Reiko Sakaguchi, Hideharu Hase, Yuko Imai, Onur K. Polat, Satoru G. Itoh, Hisashi Okumura, Yasuo Mori, Yasushi Okamura, et al. Critical contributions of pre-S1 shoulder and distal TRP box in DAG-activated TRPC6 channel by PIP2 regulation. Scientific Reports. 2022. 12. 1
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Ryo Okada, Xinwen Zhang, Yuka Harada, Zhou Wu, Hiroshi Nakanishi. Cathepsin H deficiency in mice induces excess Th1 cell activation and early-onset of EAE though impairment of toll-like receptor 3 cascade. Inflammation Research. 2018. 67. 5. 371-374
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Ryo Okada, Zhou Wu, Aiqin Zhu, Junjun Ni, Jingqi Zhang, Yoshito Yoshimine, Christoph Peters, Paul Saftig, Hiroshi Nakanishi. Cathepsin D deficiency induces oxidative damage in brain pericytes and impairs the blood-brain barrier. MOLECULAR AND CELLULAR NEUROSCIENCE. 2015. 64. 51-60
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Xinwen Zhang, Zhou Wu, Yoshinori Hayashi, Ryo Okada, Hiroshi Nakanishi. Peripheral Role of Cathepsin S in Th1 Cell-Dependent Transition of Nerve Injury-Induced Acute Pain to a Chronic Pain State. JOURNAL OF NEUROSCIENCE. 2014. 34. 8. 3013-3022
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Zhou Wu, Li Sun, Sadayuki Hashioka, Sheng Yu, Claudia Schwab, Ryo Okada, Yoshinori Hayashi, Patrick L. McGeer, Hiroshi Nakanishi. Differential pathways for interleukin-1 beta production activated by chromogranin A and amyloid beta in microglia. NEUROBIOLOGY OF AGING. 2013. 34. 12. 2715-2725
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MISC (4)：
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OKADA Ryo, NAGAOSA Kaz, KURAISHI Takayuki, NAKAYAMA Hiroshi, YAMAMOTO Naoko, NAKAGAWA Yukiko, DOHMAE Naoshi, SHIRATSUCHI Akiko, NAKANISHI Yoshinobu. Apoptosis-dependent externalization and involvement in apoptotic cell clearance of DmCaBP1, an endoplasmic reticulum protein of Drosophila. 2012. 121. 2. 74-75
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Ryo Okada, Zhou Wu, Junjun Ni, Hiroshi Nakanishi. Contribution of infiltrated monocyte/macrophages to neuropathological changes of cathepsin D-deficient mice. JOURNAL OF PHARMACOLOGICAL SCIENCES. 2013. 121. 138P-138P
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Xinwen Zhang, Yoshinori Hayashi, Zhou Wu, Ryo Okada, Hiroshi Nakanishi. Contribution of Cathepsin S (CatS) to the development of neuropathic pain through recruiting peripheral immune cells. JOURNAL OF PHARMACOLOGICAL SCIENCES. 2013. 121. 60P-60P
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Yoshinori Hayashi, Saoru Koyanagi, Naoki Kusunose, Ryo Okada, Zhou Wu, Hidetoshi Saitoh, Shinichi Kohsaka, Kazuhide Inoue, Shigehiro Ohodo, Hiroshi Nakanishi. Regulation of synaptic strength are controlled by circadian rhythm of cathepsin S expression in the microglia. JOURNAL OF PHARMACOLOGICAL SCIENCES. 2014. 124. 125P-125P
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