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J-GLOBAL ID：201901008295645063
Update date: Feb. 25, 2025 Kazuhiro Murai
ムライ カズヒロ | Kazuhiro Murai
Osaka University Graduate School of Medicine, Division of Medicine
About Osaka University Graduate School of Medicine, Division of Medicine
Research theme for competitive and other funds (5)：
- 2022 - 2025 B型肝炎ウイルス(HBV)感染・増殖に関わるウイルス-宿主相互作用連関の解明による抗HBV戦略の展開
- 2022 - 2024 B型肝炎ウイルス・C型肝炎ウイルス共感染時における線維化進展加速機構の解明
- 2020 - 2022 Elucidation of pathophysiology after hepatitis B virus cccDNA cleavage by CRISPR / Cas9 treatment
- 2020 - 2022 B型肝炎ウイルス(HBV)感染サイクル(生活環)で機能する宿主・ウイルス因子を標的とした新規抗HBV剤・HBV感染制御法の開発
- 2015 - 2017 Development of a liver carcinogenesis model using human hepatocytes and searching suitable anti-cancer drugs considering mutated genes.
- Shinnosuke Kudo, Hayato Hikita, Yoshinobu Saito, Kazuhiro Murai, Takahiro Kodama, Tomohide Tatsumi, Tetsuo Takehara. Collaborative orchestration of BH3-only proteins governs Bak/Bax-dependent hepatocyte apoptosis under antiapoptotic protein-deficiency in mice. Cell death and differentiation. 2025
- Yuki Tahata, Hayato Hikita, Satoshi Mochida, Nobuyuki Enomoto, Norifumi Kawada, Akio Ido, Daiki Miki, Masayuki Kurosaki, Hitoshi Yoshiji, Ryotaro Sakamori, et al. Factors involved in gastroesophageal varix-related events in patients with hepatitis C virus-related compensated and decompensated cirrhosis after direct-acting antiviral therapy. Hepatology research : the official journal of the Japan Society of Hepatology. 2024
- Satoshi Shigeno, Takahiro Kodama, Kazuhiro Murai, Daisuke Motooka, Akihisa Fukushima, Akira Nishio, Hayato Hikita, Tomohide Tatsumi, Toru Okamoto, Tatsuya Kanto, et al. Intrahepatic exhausted antiviral immunity in an immunocompetent mouse model of chronic hepatitis B. Cellular and molecular gastroenterology and hepatology. 2024. 101412-101412
- Emi Sometani, Hayato Hikita, Kazuhiro Murai, Hidenori Toyoda, Satoshi Tanaka, Tsugiko Oze, Jihyun Sung, Akiyoshi Shimoda, Makoto Fukuoka, Satoshi Shigeno, et al. High serum growth differentiation factor 15 is a risk factor for the occurrence of hepatocellular carcinoma in chronic hepatitis B patients treated with nucleos(t)ide analogs. Hepatology research : the official journal of the Japan Society of Hepatology. 2024
- Yukiko Ueyama-Toba, Yanran Tong, Jumpei Yokota, Kazuhiro Murai, Hayato Hikita, Hidetoshi Eguchi, Tetsuo Takehara, Hiroyuki Mizuguchi. Development of a hepatic differentiation method in 2D culture from primary human hepatocyte-derived organoids for pharmaceutical research. iScience. 2024. 27. 9. 110778-110778
- 村井 一裕, 疋田 隼人, 竹原 徹郎. ウイルス性肝炎:展望と課題 核酸アナログ製剤長期投与下のB型慢性肝炎患者における肝細胞癌関連リスク因子の検討. 肝臓. 2024. 65. Suppl.3. A782-A782
- 村井 一裕, 疋田 隼人, 成 志弦, 染谷 愛美, 三宅 崇之, 栗木 真治, 下田 彬允, 滋野 聡, 田畑 優貴, 齋藤 義修, et al. 血清中エクソソームのプロテオーム解析を用いた核酸アナログ製剤内服下のB型慢性肝炎患者における初発肝発癌診断予測マーカーの同定. 肝臓. 2024. 65. Suppl.3. A890-A890
- Murai Kazuhiro, Hikita Hayato, Takehara Tetsuo. 今後の肝炎対策はどうあるべきか((Future strategy for hepatitis control) Clinical characteristics of chronic hepatitis B patients with hepatocellular carcinoma receiving long-term nucleos (t) ide analogue administration). 肝臓. 2024. 65. Suppl.2. A569-A569
- 村井 一裕, 疋田 隼人, 下田 彬允, 栗木 真治, 染谷 愛美, 成 志弦, 福岡 誠, 滋野 聡, 西尾 啓, 齋藤 義修, et al. 薬剤ライブラリースクリーニングによるHBs抗原を減少させる化合物の同定. 肝臓. 2024. 65. Suppl.2. A642-A642
- 村井 一裕, 疋田 隼人, 竹原 徹郎. ウイルス性肝炎研究Cutting edge(A-E型,小児肝炎AAV2,創薬研究) HSPG2発現抑制がcMET発現上昇とPPARγ発現低下を介してHBVの侵入ならびに複製を阻害する. 肝臓. 2024. 65. Suppl.1. A115-A115
- 2015 - 2020 Osaka University Graduate School of Medicine
- 2003 - 2009 Osaka University Faculty of Medicine Medical School
- M.D. (大阪大学)
- Ph.D. (大阪大学)
- 2023/01 - 現在 Osaka University Hospital
- 2021/05 - 2022/12 Osaka University Graduate School of Medicine
- 2014/04 - 2021/04 Osaka University Hospital
- 2011/04 - 2014/03 大阪厚生年金病院 消化器内科 後期研修医
- 2009/04 - 2011/03 大阪厚生年金病院 初期臨床研修医
- 2024/10 - JDDW優秀演題賞
- 2022/10 - JDDW若手奨励賞
- 2021/11 - 第6回 Gilead Sciences Award
- 2021/11 - JDDW若手奨励賞
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