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J-GLOBAL ID：201901008820546985   Update date: Mar. 06, 2025

Hikino Keiko

Hikino Keiko
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Affiliation and department：
RIKEN, Japan Laboratory for Pharmacogenomics

About RIKEN, Japan Laboratory for Pharmacogenomics


Job title： Research Scientist
Research field  (2)： Pharmacology ,  Genetics
Research keywords  (4)： Pharmacogenomics ,  Clinical pharmacology ,  Population genetics ,  Pediatrics
Research theme for competitive and other funds  (7)：
  • 2024 - Challenges and opportunities in implementing clinical pharmacogenetics in Japan
  • 2022 - 2024 Identifying genetic polymorphisms and elucidating polygenic architecture associated with adverse reactions due to rituximab
  • 2021 - 2024 Risk prediction and genetic elucidation of suicide using polygenic risk scores
  • 2022 - 2024 Investigation of genes related to severe hypogammaglobulinemia / agranulocytosis with rituximab and constructing a predictive model
  • 2023 - Comprehensive analysis of genetic factors and subjective response to alcohol in Japanese youths
Show all
Papers (29)：
  • Keiko Hikino, Kensuke Shoji, Jumpei Saito, Koya Fukunaga, Xiaoxi Liu, Toshihiro Matsui, Tomoyuki Utano, Akira Takebayashi, Daisuke Tomizawa, Motohiro Kato, et al. Analysis of factors influencing the relationship between voriconazole plasma concentrations and adverse effects in a paediatric population. British Journal of Clinical Pharmacology. 2025
  • Songmi Lee, Clint L Miller, Amy R Bentley, Michael R Brown, Pavithra Nagarajan, Raymond Noordam, John Morrison, Karen Schwander, Kenneth Westerman, Minjung Kho, et al. A Large-Scale Genome-wide Association Study of Blood Pressure Accounting for Gene-Depressive Symptomatology Interactions in 564,680 Individuals from Diverse Populations. 2025
  • Shunsuke Uchiyama, Yuki Ishikawa, Katsunori Ikari, Suguru Honda, Keiko Hikino, Eiichi Tanaka, Yoichiro Kamatani, Takahisa Gono, Giulio Genovese, Masataka Kuwana, et al. Mosaic loss of chromosome Y characterises late-onset rheumatoid arthritis and contrasting associations of polygenic risk score based on age at onset. Annals of the Rheumatic Diseases. 2025
  • Kensuke Shoji, Keiko Hikino, Jumpei Saito, Toshihiro Matsui, Tomoyuki Utano, Akira Takebayashi, Daisuke Tomizawa, Motohiro Kato, Kimikazu Matsumoto, Takashi Ishikawa, et al. Pharmacogenetic implementation for CYP2C19 and pharmacokinetics of voriconazole in children with malignancy or inborn errors of immunity. Journal of Infection and Chemotherapy. 2024
  • Satoshi Koyama, Xiaoxi Liu, Yoshinao Koike, Keiko Hikino, Masaru Koido, Wei Li, Kotaro Akaki, Kohei Tomizuka, Shuji Ito, Nao Otomo, et al. Population-specific putative causal variants shape quantitative traits. Nature Genetics. 2024
ｍore...
Professional career (2)：
  • MD (Shimane University, Japan)
  • PhD (Yokohama City University, Japan)
Work history (6)：
  • 2024/04 - 現在 RIKEN Center for Integrative Medical Sciences, Laboratory for Pharmacogenomics, Research Scientist
  • 2020/10 - 2024/03 RIKEN Center for Integrative Medical Sciences, Laboratory for Pharmacogenomics, Postdoctoral Researcher
  • 2016/07 - 2020/09 RIKEN Center for Integrative Medical Sciences, Laboratory for Pharmacogenomics, Research Associate
  • 2014/08 - 2016/07 University of Chicago, Committee on Clinical Pharmacology and Pharmacogenomics, Fellow
  • 2013/07 - 2016/06 University of Chicago, Pediatric Critical Care Medicine, Fellow
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Committee career (2)：
  • 2025/01 - 現在 Member, International Exchange and Liaison Committee, Japanese Society of Clinical Pharmacology and Therapeutics
  • 2025/01 - 現在 Editorial Board of the Journal of International Medical Research
Awards (7)：
  • 2025/03 - Performance Incentive Award (FY2024), Integrative Medical Sciences, RIKEN
  • 2023/03 - Performance Incentive Award (FY2022), Integrative Medical Sciences, RIKEN
  • 2022/12 - ASHG 2022 Annual Meeting Travel Award at the Japanese Society of Human Genetics 2022 Annual Meeting
  • 2022/08 - Reviewers’ Choice Abstract Award at the American Society of Human Genetics 2022 Annual Meeting
  • 2022/03 - Performance Incentive Award (FY2021), Integrative Medical Sciences, RIKEN
Show all
Association Membership(s) (6)：
THE AMERICAN SOCIETY OF HUMAN GENETICS ,  THE JAPAN SOCIETY OF HUMAN GENETICS ,  AMERICAN SOCIETY OF CLINICAL PHARMACOLOGY AND THERAPEUTICS ,  THE JAPANESE SOCIETY OF CLINICAL PHARMACOLOGY AND THERAPEUTICS ,  AMERICAN ACADEMY OF PEDIATRICS ,  JAPAN PEDIATRIC SOCIETY
※ Researcher’s information displayed in J-GLOBAL is based on the information registered in researchmap. For details, see here.

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