Hikino Keiko

Affiliation and department：
Job title： Research Scientist

Research field (2)： Pharmacology , Genetics

Research keywords (4)： Pharmacogenomics , Clinical pharmacology , Population genetics , Pediatrics

Research theme for competitive and other funds (6)：

2022 - 2024 Identifying genetic polymorphisms and elucidating polygenic architecture associated with adverse reactions due to rituximab
2021 - 2024 Risk prediction and genetic elucidation of suicide using polygenic risk scores
2022 - 2024 Investigation of genes related to severe hypogammaglobulinemia / agranulocytosis with rituximab and constructing a predictive model
2023 - Comprehensive analysis of genetic factors and subjective response to alcohol in Japanese youths
2021 - 2023 Genetic factors influencing voriconazole pharmacokinetics

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Papers (23)：

Keiko Hikino, Satoshi Koyama, Kaoru Ito, Yoshinao Koike, Masaru Koido, Takayoshi Matsumura, Ryo Kurosawa, Kohei Tomizuka, Shuji Ito, Xiaoxi Liu, et al. RNF213 Variants, Vasospastic Angina, and Risk of Fatal Myocardial Infarction. JAMA cardiology. 2024
Kensuke Shoji, Keiko Hikino, Jumpei Saito, Toshihiro Matsui, Tomoyuki Utano, Akira Takebayashi, Daisuke Tomizawa, Motohiro Kato, Kimikazu Matsumoto, Takashi Ishikawa, et al. Pharmacogenetic implementation for CYP2C19 and pharmacokinetics of voriconazole in children with malignancy or inborn errors of immunity. Journal of Infection and Chemotherapy. 2024
Shuji Ito, Hiroshi Takuwa, Saori Kakehi, Yuki Someya, Hideyoshi Kaga, Nobuyuki Kumahashi, Suguru Kuwata, Takuya Wakatsuki, Masaru Kadowaki, Soichiro Yamamoto, et al. A genome-wide association study identifies a locus associated with knee extension strength in older Japanese individuals. Communications Biology. 2024
Mark Purdue, Diptavo Dutta, Mitchell J. Machiela, Bryan Gorman, Timothy Winter, Dayne Okuhara, Sara Cleland, Aida Ferreiro-Iglesias, Paul Scheet, Aoxing Liu, et al. Multi-ancestry genome-wide association study of kidney cancer identifies 63 susceptibility regions. Nature Genetics. 2024
Xiaoxi Liu, Satoshi Koyama, Kohei Tomizuka, Sadaaki Takata, Yuki Ishikawa, Shuji Ito, Shunichi Kosugi, Kunihiko Suzuki, Keiko Hikino, Masaru Koido, et al. Decoding triancestral origins, archaic introgression, and natural selection in the Japanese population by whole-genome sequencing. Science Advances. 2024

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Professional career (2)：

MD (Shimane University)
PhD (Yokohama City University)

Work history (6)：

2024/04 - 現在 RIKEN Center for Integrative Medical Sciences, Laboratory for Pharmacogenomics, Research Scientist
2020/10 - 2024/03 RIKEN Center for Integrative Medical Sciences, Laboratory for Pharmacogenomics, Postdoctoral Researcher
2016/07 - 2020/09 RIKEN Center for Integrative Medical Sciences, Laboratory for Pharmacogenomics, Research Associate
2014/08 - 2016/07 University of Chicago, Committee on Clinical Pharmacology and Pharmacogenomics, Fellow
2013/07 - 2016/06 University of Chicago, Pediatric Critical Care Medicine, Fellow

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Awards (6)：

2023/03 - Award for FY2022 Performance Incentives of Integrative Medical Sciences, RIKEN
2022/12 - ASHG 2022 Annual Meeting Travel Award at the Japanese Society of Human Genetics 2022 Annual Meeting
2022/08 - Reviewers’ Choice Abstract Award at the American Society of Human Genetics 2022 Annual Meeting
2022/03 - Award for FY2021 Performance Incentives of Integrative Medical Sciences, RIKEN
2013/06 - Faculty Award for Academic Excellence, Pediatric Residency Program, University of Hawaii

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Association Membership(s) (6)：

THE AMERICAN SOCIETY OF HUMAN GENETICS , THE JAPAN SOCIETY OF HUMAN GENETICS , AMERICAN SOCIETY OF CLINICAL PHARMACOLOGY AND THERAPEUTICS , THE JAPANESE SOCIETY OF CLINICAL PHARMACOLOGY AND THERAPEUTICS , AMERICAN ACADEMY OF PEDIATRICS , JAPAN PEDIATRIC SOCIETY

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