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J-GLOBAL ID:201901010871351725   Update date: Jan. 09, 2025

Nogawa Toshihiko

Nogawa Toshihiko
Research field  (1): Environmental and pharmaceutical development resources
Research theme for competitive and other funds  (6):
  • 2020 - 2023 Elucidation of molecular basis of biosynthesis with the aim of expanding the diversity of natural products
  • 2020 - 2023 ブロスライブラリーの拡張と新規活性物質探索に向けた多変量スクリーニング系の構築
  • 2017 - 2020 Construction of a fraction lirary with wide diversity and application for discovery of new bioactive compounds
  • 2016 - 2019 Development of small-molecule inhibitors targeting glucose-independent cancer metabolism
  • 2014 - 2017 Application of microbial metabolite fraction library and NPPlot on discovery of new metabolites
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Papers (74):
  • Nobumoto Watanabe, Emiko Sanada, Akiko Okano, Toshihiko Nogawa, Ngit Shin Lai, Yui Mazaki, Makoto Muroi, Yoko Yashiroda, Minoru Yoshida, Hiroyuki Osada. Violaceoid F induces nuclear translocation of FOXO3a by inhibiting CRM1 via a novel mechanism and suppresses HeLa cell growth. FEBS letters. 2024
  • Katsuyuki Sakai, Yushi Futamura, Toshihiko Nogawa, Yuzhu Zhao, Hiroyuki Koshino, Hiroyuki Osada, Shunji Takahashi. Production of Kinanthraquinone D with Antimalarial Activity by Heterologous Gene Expression and Biotransformation in Streptomyces lividans TK23. Journal of Natural Products. 2024. 87. 4. 855-860
  • Toshihiko Nogawa, Naoki Kato, Takeshi Shimizu, Akiko Okano, Yushi Futamura, Shunji Takahashi, Hiroyuki Koshino, Hiroyuki Osada. Wakodecaline C, new tetrahydrofuran-fused decalin metabolite isolated from fungus Pyrenochaetopsis sp. RK10-F058. The Journal of antibiotics. 2023. 76. 6. 346-350
  • Makoto Kawatani, Harumi Aono, Sayoko Hiranuma, Takeshi Shimizu, Makoto Muroi, Toshihiko Nogawa, Tomokazu Ohishi, Shun-Ichi Ohba, Manabu Kawada, Kanami Yamazaki, et al. Identification of a dihydroorotate dehydrogenase inhibitor that inhibits cancer cell growth by proteomic profiling. Oncology research. 2023. 31. 6. 833-844
  • Takayuki Motoyama, Toshihiko Nogawa, Takeshi Shimizu, Makoto Kawatani, Takeshi Kashiwa, Choong-Soo Yun, Daisuke Hashizume, Hiroyuki Osada. Fungal NRPS-PKS Hybrid Enzymes Biosynthesize New gamma-Lactam Compounds, Taslactams A-D, Analogous to Actinomycete Proteasome Inhibitors. ACS CHEMICAL BIOLOGY. 2023
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MISC (28):
  • 野川俊彦, RAWA Mira Syahfriena Amir, RAWA Mira Syahfriena Amir, 岡野亜紀子, 二村友史, 中村健道, WAHAB Habibah A., 長田裕之. New Peptaibols Isolated from a Fungus Trichoderma sp. RK10-F026 as Culture Condition Depending Metabolites. 質量分析総合討論会講演要旨集. 2021. 69th
  • 本山高幸, 野川俊彦, 清水猛, 川谷誠, 二村友史, YUN Choong-Soo, 長田裕之. Isolation of new bioactive natural products by using homologs of a new type secondary metabolism enzyme TAS1. 日本農芸化学会大会講演要旨集(Web). 2020. 2020
  • 古山祐貴, 古山祐貴, 本山高幸, 野川俊彦, 鎌倉高志, 長田裕之. Functional analysis of secondary metabolites of the rice blast fungus induced by actinomycetal antibiotics. 日本農芸化学会大会講演要旨集(Web). 2020. 2020
  • 野川俊彦, 寺井淳高, 新家一男, 池田治生, 高橋俊二, 長田裕之. Structures of new verticilactam derivatives by heterologous expression. 日本農芸化学会大会講演要旨集(Web). 2020. 2020
  • 野川俊彦. 糸状菌からのデカリン含有化合物の単離と構造. 理研シンポジウムデカリン化合物の化学合成と生合成 令和元年. 2019
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