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J-GLOBAL ID：201901011644630320
Update date: Mar. 12, 2025 Chang Jen-Chien
チャン レンチエン | Chang Jen-Chien
RIKEN Research DX Foundation Team, TRIP Headquarters
About RIKEN Research DX Foundation Team, TRIP Headquarters
Job title： Expert Technician
Research field (6)：
Genomics
, Molecular biology
, Bio-, chemical, and soft-matter physics
, Nanobioscience
, Genetics
, Biophysics
Research keywords (9)：
Transcription
, Nucleosome
, Epigenetics
, single-molecule imaging
, Bioinformatics
, histone modification
, Single-molecule experiment
, Chromatin
, Epigenome
Research theme for competitive and other funds (1)： - 2017 - 2019 Detecting combinatorial histone modification dynamics at single nucleosome resolution for key genes in Epithelial-Mesenchymal-Transition
- Nando D Das, Jen-Chien Chang, Chung-Chau Hon, S Thomas Kelly, Shinsuke Ito, Marina Lizio, Bogumil Kaczkowski, Hisami Watanabe, Keisuke Katsushima, Atsushi Natsume, et al. Defining super-enhancers by highly ranked histone H4 multi-acetylation levels identifies transcription factors associated with glioblastoma stem-like properties. BMC genomics. 2023. 24. 1. 574-574
- Jacob Matthew Schreiber, Carles A. Boix, Jin wook Lee, Hongyang Li, Yuanfang Guan, Chun-Chieh Chang, Jen-Chien Chang, Alex Hawkins-Hooker, Bernhard Schölkopf, Gabriele Schweikert, et al. The ENCODE Imputation Challenge: a critical assessment of methods for cross-cell type imputation of epigenomic profiles. Genome Biology. 2023. 24. 1
- Chi Wai Yip, Chung-Chau Hon, Kayoko Yasuzawa, Divya M. Sivaraman, Jordan A. Ramilowski, Youtaro Shibayama, Saumya Agrawal, Anika V. Prabhu, Callum Parr, Jessica Severin, et al. Antisense-oligonucleotide-mediated perturbation of long non-coding RNA reveals functional features in stem cells and across cell types. Cell Reports. 2022. 41. 13. 111893-111893
- Jonathan Moody, Tsukasa Kouno, Jen-Chien Chang, Yoshinari Ando, Piero Carninci, Jay W Shin, Chung-Chau Hon. SCAFE: a software suite for analysis of transcribed cis-regulatory elements in single cells. Bioinformatics. 2022. 38. 22. 5126-5128
- Jordan A Ramilowski, Chi Wai Yip, Saumya Agrawal, Jen-Chien Chang, Yari Ciani, Ivan V Kulakovskiy, Mickaël Mendez, Jasmine Li Ching Ooi, John F Ouyang, Nick Parkinson, et al. Functional annotation of human long noncoding RNAs via molecular phenotyping. Genome research. 2020. 30. 7. 1060-1072
- Jen-Chien Chang, Kazuhide Watanabe, Takashi Umehara, Yuichi Taniguchi, Yuko Sato, Hiroshi Kimura, Akiko Minoda. Mapping Combinatorial Epigenetic Modifications at Single Nucleosome Resolution. Biophysical Journal. 2018. 114. 3. 254a-254a
- Jen-Chien Chang, Takashi Umehara, Keisuke Fujita, Yuichi Taniguchi, Toshio Yanagida, Akiko Minoda. Single-Molecule Analysis of Colocalized Epigenetic Modifications. BIOPHYSICAL JOURNAL. 2016. 110. 3. 66A-66A
- Jen-Chien Chang, Michel de Messieres, Ping-Chun Li, Olga I. Kulaeva, Vasily M. Studitsky, Edward T. Yu, Arthur La Porta. Mechanical Stability of Mononucleosome Revealed by Optical Torque Wrench. BIOPHYSICAL JOURNAL. 2013. 104. 2. 580A-580A
- Michel de Messieres, Jen-Chien Chang, Ashton T. Belew, Arturas Meskauskas, Jonathan D. Dinman, Arthur La Porta. Single-Molecule Optical Trap Study of Human CCR5 mRNA Structure. BIOPHYSICAL JOURNAL. 2012. 102. 3. 384A-384A
- Jen-Chien Chang, Michel de Messieres, Olga I. Kulaeva, Vasily M. Studitsky, Arthur La Porta. Single-Molecule Twist and Stretch of Mononucleosome using Optical Torque Wrench. BIOPHYSICAL JOURNAL. 2012. 102. 3. 481A-481A
- Understanding epigenome by the analysis of combinatorial histone modifications
2019
- 2008 - 2014 University of Maryland, College Park Department of Physics
- 2003 - 2007 National Taiwan University Department of Physics
- PhD (University of Maryland)
- 2018/04 - 現在 RIKEN Center for Integrative Medical Sciences Research Scientist
- 2017/04 - 2018/03 RIKEN Center for Life Science Technologies Research Scientist
- 2014/06 - 2017/03 RIKEN Center for Life Science Technologies Postdoctoral Researcher
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