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J-GLOBAL ID：201901011894843923 Update date: Mar. 29, 2025

CHINEN Takumi

Affiliation and department：
Job title：助教

Research keywords (5)：ガンマチューブリン特異的阻害薬 , 分裂期作用薬 , Centrosome , Microtubule , Mitotic spindle

Research theme for competitive and other funds (15)：

2022 - 2027 微小管-紡錘体極マトリクスからなるLLPS複合体形成を介した、タキソールの抗がんメカニズムの解明
2023 - 2026 染色体数に応じた紡錘体形状の適応メカニズムの解明
2022 - 2024 分裂期タイマーを介したがん抑制機構の解明
2022 - 2023 難治性ALLに対する網羅的な創薬標的同定
2022 - 2023 血液がん細胞の紡錘体脆弱性の理解と創薬応用

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Papers (44)：

Kei K Ito, Kasuga Takumi, Kyohei Matsuhashi, Hirokazu Sakamoto, Kaho Nagai, Masamitsu Fukuyama, Shohei Yamamoto, Takumi Chinen, Shoji Hata, Daiju Kitagawa. Multimodal mechanisms of human centriole engagement and disengagement. The EMBO journal. 2025
Aoi Kimishima, Sota Honma, Atsushi Kimishima, Atsuka Nishitomi, Masako Honsho, Paul Wasuwanich, Hiroki Kojima, Toshiyuki Tokiwa, Akihiro Sugawara, Yasuko Araki, et al. Synthesis and biological evaluation of MS-347a derivatives against plant pathogenic fungi based on a strategy of laeA gene introduction. Journal of Pesticide Science. 2024. 49. 4. 224-231
Sota Honma, Aoi Kimishima, Satoshi Kato, Akari Horiuchi, Rei Hokari, Masako Honsho, Hiroki Kojima, Toshiyuki Tokiwa, Akihiro Sugawara, Masato Iwatsuki, et al. The isolation of sclerotinin A as an anti-malarial compound by utilization of a global secondary metabolism regulator, laeA gene. Bioorganic & medicinal chemistry letters. 2024. 113. 129947-129947
Aoi Kimishima, Atsuka Nishitomi, Iori Tsuruoka, Masako Honsho, Sota Negami, Sota Honma, Katsuyuki Sakai, Toshiyuki Tokiwa, Hiroki Kojima, Kenichi Nonaka, et al. Synthesis and biological evaluation of burnettiene A derivatives enabling discovery of novel fungicide candidates. Journal of pesticide science. 2024. 49. 3. 159-167
Aoi Kimishima, Atsuka Nishitomi, Naozumi Kondo, Sota Honma, Masako Honsho, Sota Negami, Serino Maruyama, Kazuki Taguchi, Hidehito Matsui, Hideaki Hanaki, et al. Isolation of microorganisms from the feces of Kitasato Yakumo beef cattle as bioactive natural product producers. Bioscience, Biotechnology, and Biochemistry. 2024

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MISC (6)：

竹田穣, 知念拓実, 畠星治, 北川大樹. カレントトピックス:中心小体の基本骨格である三連微小管の形成メカニズム. 実験医学(羊土社). 2024. 42. 11. 1945-1948
Yutaka Takeda, Kanako Kuroki, Takumi Chinen, Daiju Kitagawa. Centrosomal and Non-centrosomal Functions Emerged through Eliminating Centrosomes. Cell structure and function. 2020. 45. 1. 57-64
Kaho Hashimoto, Takumi Chinen, Daiju Kitagawa. Mechanisms of spindle bipolarity establishment in acentrosomal human cells. Molecular & cellular oncology. 2020. 7. 3. 1743899-1743899
TAKEDA Yutaka, CHINEN Takumi, KITAGAWA Daiju. 20191001. Farumashia. 2019. 55. 10. 954-958
知念拓実. 微小管形成中心~新たな抗がん剤標的~. 生物工学会誌. 2017. 95. 6. 336

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Patents (1)：

微小管重合阻害剤

Books (1)：

The Yeast Role in Medical Applications
2018

Lectures and oral presentations (20)：

ヒト非中心体性細胞における染色体分配機構
(日本遺伝学会大会プログラム・予稿集 2018)
Mechanisms of the spindle bipolarity establishment in human acentrosomal cells
(Joint Meeting of JSCB 70th & JSDB 51st 2018)
抗腫瘍活性物質vicenistatin耐性に関与する遺伝子の同定
(日本農芸化学会関東支部講演要旨集 2017)
抗腫瘍活性物質vicenistatin耐性に関与する遺伝子の同定
(日本農芸化学会大会講演要旨集(Web) 2017)
Glaziovianin A類縁体O<sup>6</sup>-demethyl benzyl glaziovianin Aによる微小管重合阻害
(メディシナルケミストリーシンポジウム講演要旨集 2016)

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Education (3)：

2012 - 2014 筑波大学大学院生命環境科学研究科生物機能科学専攻
2010 - 2012 筑波大学大学院生命環境科学研究科生物資源科学専攻
2006 - 2010 筑波大学第二学群生物学類

Professional career (1)：

博士(農学) (筑波大学)

Work history (7)：

2020/02 - 現在 The University of Tokyo Graduate School of Pharmaceutical Sciences
2019/04 - 2020/01 The University of Tokyo Graduate School of Pharmaceutical Sciences
2017/04 - 2019/03 National Institute of Genetics
2016/11 - 2017/03 National Institute of Genetics National Institute of Genetics
2015/12 - 2016/10 理化学研究所生命システム研究センター特別研究員

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Awards (8)：

2018/06 - 日本細胞生物学会・日本発生生物学会合同大会若手優秀発表賞
2018/03 - 日本農芸化学会トピックス賞
2014/11 - 筑波大学学長表彰
2014 - 上原記念生命科学財団海外留学助成ポストドクトラルフェローシップ
2012/10 - 日本農芸化学会関東支部大会若手奨励賞

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Association Membership(s) (4)：

THE JAPANESE BIOCHEMICAL SOCIETY , JAPANESE SOCIETY FOR CHEMICAL BIOLOGY , JAPAN SOCIETY FOR CELL BIOLOGY , JAPAN SOCIETY FOR BIOSCIENCE, BIOTECHNOLOGY, AND AGROCHEMISTRY

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