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J-GLOBAL ID：201901012378170897
Update date: Jan. 27, 2025 Mishima Yuta
ミシマ ユウタ | Mishima Yuta
筑波大学 医学医療系、トランスボーダー医学研究センター
About 筑波大学 医学医療系、トランスボーダー医学研究センター
Job title： 助教
Homepage URL (1)： https://www.linkedin.com/in/yutamishima/
Research keywords (6)：
Biomedical engineering
, Regulatory Science
, Industry-academia collaboration
, Tumor immunology
, Epigenetics
, Regenerative medicine
Research theme for competitive and other funds (9)： - 2022 - 2025 Development and demonstration of a patient tissue-derived 3D tumor-on-a-chip for evaluation of T cell function in cancer immunotherapy
- 2020 - 2023 Development of a 3D tumor-on-a-chip platform for cancer immunotherapy
- 2020 - 2022 Development of the killing function of iPSC derived CAR-T cell for solid tumor.
- 2017 - 2020 患者由来がん組織を培養可能なデバイスの開発とがん免疫療法の評価法の構築
- 2016 - 2019 iPS 細胞由来再生 T 細胞とがん特異抗原レセプター遺伝子導入による免疫療法の開発
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- Yuta Mishima, Shintaro Okada, Akihiro Ishikawa, Bo Wang, Masazumi Waseda, Mika K. Kaneko, Yukinari Kato, Shin Kaneko. Development of chimeric antigen receptor T cells targeting cancer-expressing podocalyxin. Regenerative Therapy. 2025. 28. 292-300
- Seung Kak Shin, Yuta Mishima, Yoonseok Lee, Oh Sang Kwon, Ju Hyun Kim, Yun Soo Kim, Shin Kaneko. Current Landscape of Adoptive Cell Therapy and Challenge to Develop “Off-The-Shelf” Therapy for Hepatocellular Carcinoma. Journal of Gastroenterology and Hepatology. 2025
- Hiroshi Ohno, Takenori Nishimura, Kenta Kainoh, Yoshitaka Ohashi, Naoko Onodera, Mayuko Kano, Lay Nurhana Sari, Masato Masuda, Yoshiaki Tamura, Yusuke Hayashi, et al. Label-free imaging of intracellular structures in living mammalian cells via external apodization phase-contrast microscopy. 2024
- Hisashi Takei, Juan Luiz Coelho-Silva, Cristina Tavares Leal, Adriana Queiroz Arantes Rocha, Thiago Mantello Bianco, Robert S. Welner, Yuta Mishima, Ikei S Kobayashi, Ann Mullally, Keli Lima, et al. Suppression of multiple anti-apoptotic BCL2 family proteins recapitulates the effects of JAK2 inhibitors in JAK2V617F driven myeloproliferative neoplasms. Cancer Science. 2021
- Shoichi Iriguchi, Yutaka Yasui, Yohei Kawai, Suguru Arima, Mihoko Kunitomo, Takayuki Sato, Tatsuki Ueda, Atsutaka Minagawa, Yuta Mishima, Nariaki Yanagawa, et al. A clinically applicable and scalable method to regenerate T-cells from iPSCs for off-the-shelf T-cell immunotherapy. Nature Communications. 2021. 12. 1
- 三嶋 雄太, 金子 新. iPS細胞の応用研究 : これまでの応用例と課題,最新の応用例 (特集 iPSの社会的意義). 遺伝 : 生物の科学. 2017. 71. 5. 425-430
- Yuta Mishima, Satoru Miyagi, Atsunori Saraya, Masamitsu Negishi, Mitsuhiro Endoh, Naoto Yamaguchi, Issay Kitabayashi, Haruhiko Koseki, Atsushi Iwama. The Hbo1-Brd1/Brpf2 HAT Complex Is Required for Erythropoiesis In Fetal Liver. BLOOD. 2010. 116. 21. 1582-1583
Books (3)：
- 真の実臨床応用をめざした再生医療2023 : リバーストランスレーショナルリサーチのいまと産業化のための技術開発
羊土社 2023 ISBN:9784758104081 - Forefront of gene therapy
2022 - 『生物の科学 遺伝』
株式会社エヌ・ティー・エス 2017
-
MODELING CANCER IMMUNOTHERAPY IN A PERFUSABLE 3D VASCULARIZED TUMOR-ON-A-CHIP USING HLA-KO UNIVERSAL HUMAN IPSC-DERIVED ENDOTHELIAL CELLS
(ISSCR 2020 Virtual 2020) -
Modeling cancer immunotherapy in a perfusable 3D vascularized tumor-on-a-Chip using universal iPSC-derived endothelial cells.
(CiRA 2019 International Symposium 2019) -
iPS細胞とレギュラトリーサイエンス
(順天堂大学医学部 医療の経済学 第10回講義 2019) -
iPS細胞が作り出す社会とビジネス
(関⻄大学 商学部新入生歓迎特別行事講演 2019) -
がんと再生医療
(つくば再生医療・細胞治療カンファレンス講演会 2019)
- 博士(医薬学)
- 2021/04 - 現在 University of Tsukuba Hospital Department of Regenerative Medicine Deputy Director
- 2020/03 - 現在 University of Tsukuba Faculty of Medicine Assistant Professor
- 2017/04 - 2020/02 Kyoto University Center for iPS cell Research and Application (CiRA) T-CiRA program, Kaneko Project Sub-PI
- 2016/04 - 2019/03 Japan society for the promotion of science (JSPS) JSPS Research Fellow
- 2015/06 - 2016/04 Kyoto University Center for iPS research and Application (CiRA) Program specific researcher
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- 2017/04 - 2020/03 バイオインダストリー協会 バイオサイエンスとインダストリー編集委員会 再生医療トピックス委員
- 2013/06 - The Uehara Memorial Foundation Uehara postdoctoral fellowship
- 2013/03 - 千葉大学大学院 医学薬学府長賞(首席)
- 2012/12 - 千葉大学 G-COE プログラム Annual Best Research Award
- 2012/09 - 東京エレクトロンデバイス株式会社 第1回 Microsoft Kinnect for Windows Contest 技術賞
- 2012/03 - 日本薬学会 優秀発表賞(第13回 Pharmaco-hematology シンポジウム)
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Japanese Cancer Association
, THE JAPANESE SOCIETY FOR REGENERATIVE MEDICINE
, International Society of Stem Cell Research (ISSCR)
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