Sawamura Tatsuya

サワムラタツヤ | Sawamura Tatsuya

Affiliation and department：
Job title： Professor
Homepage URL (1)： http://goo.gl/sgZ88p

Research field (2)： Clinical pharmacy , Physiology

Research theme for competitive and other funds (40)：

2023 - 2026 骨格筋の新機能としての老廃物除去機能を解明する
2021 - 2026 変性リポ蛋白を含む脂質プロフィールと脳・心血管疾患の関連、その規定要因の解明
2022 - 2025 脂質異常症が高血圧や高血圧性腎障害を増強する新規メカニズムの解明
2021 - 2024 肺高血圧症病態生理における血管内皮機能分子の意義の解明
2019 - 2023 The risk assessment of coronary artery diseas by a novel method to measure dysfunctional HDL-C

2018 - 2022 Basic research for a new concurrent treatment against lifestyle diseases and Alzehimer disease.

2018 - 2022 Elucidation of the significance of LOX-1 and endothelial dysfunction as the pathological basis of disseminated intravascular coagulation.

2018 - 2021 Interactions between lipid profile and PCSK9 changes and a role of oxidatively modified LDL on DAAs treatment

2017 - 2020 Elucidation of the relationships between pathogenic substances and DAMPs receptors.

2016 - 2020 Elucidation of Involvement of LOX-1 in inflammatory bone destruction and the molecular mechanism for the LOX-1 actions, and an approach to develop the new drug for bone diseases.

2016 - 2020 Assessment of quality of lipid parameters as a novel risk factor for cardiovascular diseases in community-based epidemiologic studies.

2016 - 2018 Elucidation of the mechanism of gout attacks

2014 - 2018 Basic research for the clinical application of drugs for a life style disease to treat Alzheimer's disease.

2014 - 2017 Severity assessment and prognostic evaluation of idiopathic dilated cardiomyopathy by measurement of soluble LOX-1

2013 - 2016 The elucidation of the role of lipid in bone resorption of inflammatory bone diseases; in particular, the exploration of the role of LOX-1 as an oxidized LDL receptor

2013 - 2016 Elucidation of physiological significance of LOX-1 binding molecules

2011 - 2015 The effect of soluble form LOX-1 and LOX-1 ligands containing apolipoprotein B on subclinical atherosclerosis in community dwellers..

2011 - 2013 Clinical implication of biomarker for patients with acute stroke

2010 - 2012 Involvement of the oxidized low-density lipoprotein/lectin-like oxidized low-density lipoprotein receptor-1 system to joint cartilage degeneration

2010 - 2012 Pathophysiological significance of the factor which enhances the action of oxidized LDL, platelets, and leukocytes on vascular wall.

2006 - 2007 Clarification of the mechanisms of cardiovascular dysfunction and the resultant organ failure

2004 - 2005 酸化LDL及びレクチン様酸化LDL受容体(LOX-1)の心移植後慢性拒絶への関与

2004 - 2005 STUDY ON THE SIGNIFICANCE OF LOX-1 IN OXIDATIVE STRESS-RELATED BIOLOGICAL RESPONSES

2002 - 2002 原虫感染におけるスカベンジャー受容体の機能

2001 - 2002 レクチン様酸化LDL受容体の機能と病態生理への関わり

2001 - 2002 熱帯熱マラリアの病理における血管内皮細胞の酸化LDL受容体LOX-1の役割

1999 - 2002 Investigations for developing novel diagnostic methods, therapeutics, and drugs utilizing lectin-like oxidized LDL receptor-1 (LOX-1)

2000 - 2000 レクチン様酸化LDL受容体の機能と病態生理的役割

1999 - 2000 血管内皮細胞の機能変化のメカニズム

1999 - 1999 レクチン様酸化LDL受容体の機能と病態生理的役割

1997 - 1998 Pharmacology

1995 - 1998 Study on the regulatory mechanisms of endothelium-dependent vasoconstriction and growth of vascular cells

1996 - 1996 Pharmacology of endothelin and endothelin receptor

1994 - 1996 新しい循環調節薬としてのエンドセリン変換酵素抑制薬開発のための研究

1994 - 1995 Pharmacology of endothelin receptor and its agonist/antagonist

1993 - 1995 エンドセリン誘発収縮に関与する新しい因子の検索とそのクローニング

1994 - 1994 エンドセリン変換酵素によるエンドセリン産生制御

1994 - 1994 バイオプテリン結合活性をもつ新しい機能蛋白質群のcDNAクローニング

1993 - 1993 エンドセリン変換酵素によるエンドセリン産生制御

1993 - 1993 テトラヒドロビオプテリン受容体のクローニング及びその機能解析

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Papers (252)：

Nguyen, C.T., Nakayama, M., Ishigaki, H., Kitagawa, Y., Kakino, A., Ohno, M., Shingai, M., Suzuki, Y., Sawamura, T., Kida, H. and Ito, Y. Increased expression of CD38 on endothelial cells in SARS-CoV-2 infection in cynomolgus macaque. Virology. 2024. 594. 110052
Villalobos-Labra, R., Liu, R., Spaans, F., Saez, T., Semeria Maitret, T., Quon, A., Sawamura, T., Cooke, C.M. and Davidge, S.T. Placenta-derived extracellular vesicles from preeclamptic pregnancies impair vascular endothelial function via lectin-like oxidized LDL receptor-1. Hypertension. 2023. 80. 2226-2238
Kraler, S., Sawamura, T., Harn, G.Y., Chen, C.H. and Akhmedov, A. Editorial: Implications of lipids and modified lipoproteins in atherogenesis: from mechanisms towards novel diagnostic and therapeutic targets. Front Cardiovasc Med. 2023. 10. 1245716
Roper, B.W.R., Tiede, C., Abdul-Zani, I., Cuthbert, G.A., Jade, D., Al-Aufi, A., Critchley, W.R., Saikia, Q., Homer-Vanniasinkam, S., Sawamura, T., McPherson, M.J., Harrison, M.A., Tomlinson, D.C. and Ponnambalam, S. "Affimer" synthetic protein scaffolds block oxidized LDL binding to the LOX-1 scavenger receptor and inhibit ERK1/2 activation. J Biol Chem. 2023. 299. 105325
Takahashi, K., Aono, J., Nakao, Y., Hamaguchi, M., Suehiro, C., Kurata, M., Sakaue, T., Kakino, A., Sawamura, T., Inoue, K., Ikeda, S., Suzuki, J. and Yamaguchi, O. LOX-1 deficiency increases ruptured abdominal aortic aneurysm via thinning of adventitial collagen. Hypertens Res. 2023. 46. 1. 63-74

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