Kousuke Uranishi

Affiliation and department：

Research field (1)： Medical biochemistry

Research keywords (4)： Meiosis , PRC1.6 , Epigenetics , ES cells

Research theme for competitive and other funds (5)：

2023 - 2026 Elucidation of the molecular mechanisms by which germ cells inactivate the function of polycomb that acts against meiotic onset
2023 - 2026 非生殖細胞での減数分裂関連遺伝子の異所的な発現を抑制するための分子基盤の解明
2022 - 2025 非生殖細胞における減数分裂関連遺伝子の安定的な発現抑制のための分子基盤の解明
2020 - 2022 Analysis of the biological significance and molecular mechanisms of meiosis-specific production of Mga variants.
2014 - 2016 Dax1を介したES細胞の自己複製維持機構の解析

Papers (15)：

Takehiro Nogi, Kousuke Uranishi, Ayumu Suzuki, Masataka Hirasaki, Tina Nakamura, Tomiei Kazama, Hiroshi Nagasaka, Akihiko Okuda, Tsutomu Mieda. Similarity and dissimilarity in alterations of the gene expression profile associated with inhalational anesthesia between sevoflurane and desflurane. PloS one. 2024. 19. 3. e0298264
Yoshiaki Mihara, Masataka Hirasaki, Yosuke Horita, Takashi Fujino, Hisayo Fukushima, Yasuo Kamakura, Kousuke Uranishi, Yasumitsu Hirano, Shomei Ryozawa, Masanori Yasuda, et al. PTEN-induced kinase 1 gene single-nucleotide variants as biomarkers in adjuvant chemotherapy for colorectal cancer: a retrospective study. BMC gastroenterology. 2023. 23. 1. 339-339
Yuka Kitamura, Ayumu Suzuki, Kousuke Uranishi, Masazumi Nishimoto, Seiya Mizuno, Satoru Takahashi, Akihiko Okuda. Alternative splicing for germ cell-specific Mga transcript can be eliminated without compromising mouse viability or fertility. Development, growth & differentiation. 2022. 64. 7. 409-416
Yu Miyama, Kent Kanao, Kousuke Uranishi, Masataka Hirasaki, Masanori Yasuda. Complete response to pembrolizumab in a patient with recurrent and metastatic urothelial bladder carcinoma reflecting coexisting sarcomatoid subtype and glandular differentiation: a case report. International Cancer Conference Journal. 2022. 12. 1. 24-30
Kentaro Mochizuki, Jafar Sharif, Kenjiro Shirane, Kousuke Uranishi, Aaron B Bogutz, Sanne M Janssen, Ayumu Suzuki, Akihiko Okuda, Haruhiko Koseki, Matthew C Lorincz. Repression of germline genes by PRC1.6 and SETDB1 in the early embryo precedes DNA methylation-mediated silencing. Nature communications. 2021. 12. 1. 7020-7020

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MISC (7)：

西本正純, 西本正純, 浦西洸介, 浅賀正充, 鈴木歩, 水野洋介, 平崎正孝, 奥田晶彦. Yapの異常な活性化による形質転換はYap/TEAD複合体によるcMyc遺伝子の転写亢進による. 日本分子生物学会年会プログラム・要旨集(Web). 2019. 42nd
平崎正孝, 鈴木歩, 浦西洸介, 浅賀正充, 西本正純, 奥田晶彦. MBDドメインが欠失したMbd3バリアントによるES細胞の分化多能性賦与機構の解明. 日本生化学会大会(Web). 2017. 90th
鈴木歩, 平崎正孝, 浅賀正充, 浦西洸介, 西本正純, 奥田晶彦. Maxは体細胞分裂から減数分裂への切り替えを制御するか. 日本生化学会大会(Web). 2017. 90th
平崎正孝, 鈴木歩, 浦西洸介, 浅賀正充, 西本正純, 奥田晶彦. Mbd3/NuRD転写抑制複合体によるES細胞への分化多能性賦与機構の解明. 日本分子生物学会年会プログラム・要旨集(Web). 2016. 39th
西本正純, 鈴木歩, 浦西洸介, 浅賀正充, 平崎正孝, 奥田晶彦. Yapによる細胞の形質転換におけるmiR29を介さない経路の重要性. 日本分子生物学会年会プログラム・要旨集(Web). 2016. 39th

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Professional career (1)：

Ph.D (Kanazawa University)

Work history (6)：

2020/05 - 現在 Saitama Medical University Research Center for Genomic Medicine
2019/04 - 2020/04 Saitama Medical University Research Center for Genomic Medicine Division of Developmental Biology
2016/04 - 2019/03 Saitama Medical University Research Center for Genomic Medicine Division of Developmental Biology
2015/05 - 2016/03 Memorial sloan Kettering Cancer Center Human Oncology & Pathogenesis Program Research Fellow
2015/04 - 2016/03 Kanazawa University

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Awards (2)：

2012/06 - International Society for Stem Cell Research ISSCR 10th Annual meeting Travel award
2011/03 - 金沢大学平成22年度金沢大学大学院医学系研究科(修士課程)優秀論文賞

Association Membership(s) (2)：

International Society for Stem Cell Research , THE MOLECULAR BIOLOGY SOCIETY OF JAPAN

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