Takeshi Moriishi

タケシモリイシ | Takeshi Moriishi

Affiliation and department：

Research field (1)： Cell biology

Research theme for competitive and other funds (33)：

2023 - 2027 Runx1の軟骨細胞特異的エンハンサーを標的とした変形性関節症治療薬の開発
2023 - 2026 歯根吸収発症における細胞小器官分解システム関連蛋白の役割
2023 - 2026 骨芽細胞に分化する新規DMP1陽性未分化間葉系細胞の表面マーカーと遺伝子発現解析
2021 - 2025 Comprehensive understanding of the enhancer cluster regulating the expression of Indian hedgehog in the skeletal system
2021 - 2024 ノックアウトマウスとレポーターマウス作製によるType I Runx2の機能解明

2021 - 2023 Investigation of the mechanism of actions of the helioxanthin-derivative and its application as a multi-kinase inhibitor

2018 - 2023 Elucidation of the mechanism in the regulation of chondrocyte-specific Runx2 enhancer and development of the drug for osteoarthritis

2018 - 2021 A study of osteocalcin-deficient mice to clarify the bone phenotypes and extraskeletal functions

2017 - 2020 Elucidation of the function of Supt3 in skeletal formation and its interaction with Runx2 promoter.

2014 - 2019 Elucidation of the transcriptional regulation of Runx2 and development of the drugs for osteoporosis and osteoarthritis

2015 - 2018 Analysis of the function of microtubule-associated protein tau (Mapt) and nestin in the formation of odontoblast processes using the genetically modified mice

2015 - 2018 Studies for expression and function of Runx2 isoforms

2015 - 2018 A study of increase bone volume using transgenic mice with osteoblasts that express proliferation and anti-apoptotic factors

2014 - 2016 Elucidation of the pathogenesis of disuse osteoporosis and steroid-induced osteoporosis using Fkbp5 knockout mice

2014 - 2015 Runx2遺伝子の軟骨細胞特異的エンハンサーの同定とその制御機構の解明

2012 - 2015 Molecular morphological examination about the formation of processes in the osteoblasts and odontoblasts

2012 - 2015 A study of mechanical stress response genes via osteocyte network

2012 - 2014 Identification and functional analysis of a novel substrate of Pdk4 in the regulation of osteoclastogenesis in the unloaded condition

2010 - 2014 The mechanism of transcriptional regulation of Runx2 gene and the program of skeletal development

2010 - 2012 アポトーシス抑制遺伝子Bcl-X_Lの骨の形成及び維持における機能解明

2010 - 2012 Functional analysis of a mechanical stress responsible geneFbxo32 on bone volume regulation

2010 - 2011 The molecule mechanism of the bone mass regulation by a bone cell network

2010 - 2011 The role of anti-apoptotic Bcl-X_L in bone formation and maintenance of bone mass

2008 - 2010 力学的負荷変動時に、骨細胞で制御される骨芽細胞を介した破骨細胞活性化因子の探索

2008 - 2009 骨芽細胞・軟骨細胞制御因子Runx2を調節する化合物のスクリーニング系の開発

2008 - 2009 Study of osteoclast activating factor when mechanical stress changes through osteoblast controlled by osteocyte

2006 - 2008 アポトーシス抑制遺伝子Bcl-2の骨の形成および維持における機能解明

2007 - 2008 Elucidation of the mechanism of skeletal development using Runx2 and Cbfb conditional knockout mice

2006 - 2007 アポトーシス抑制遺伝子Bcl-2の骨の形成および維持における機能解明

2003 - 2004 両生類大腿骨における軟骨内骨化に関連する因子の検索

2002 - 2003 脊椎動物の進化と骨格の働きについて

2003 - 2003 両生類大腿骨における軟骨内骨化に関連する因子の検索

2002 - 2002 脊椎動物の進化と骨格の働きについて

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Papers (43)：

Hiroki Yoshioka, Sarah Tominaga, Fumiya Amano, Sixun Wu, Shintaro Torimoto, Takeshi Moriishi, Yosuke Tsukiboshi, Satoshi Yokota, Nobuhiko Miura, Naoki Inagaki, et al. Juzentaihoto alleviates cisplatin-induced renal injury in mice. Traditional and Kampo Medicine. 2024. 11. 2. 147-155
Qing Jiang, Kenichi Nagano, Takeshi Moriishi, Hisato Komori, Chiharu Sakane, Yuki Matsuo, Zhiguo Zhang, Riko Nishimura, Kosei Ito, Xin Qin, et al. Roles of Sp7 in osteoblasts for the proliferation, differentiation, and osteocyte process formation. Journal of Orthopaedic Translation. 2024. 47. 161-175
Yukako Nashiro-Oyakawa, Yuka Hotokezaka, Hitoshi Hotokezaka, Takeshi Moriishi, Mariko Funaki-Dohi, Yosuke Iuchi, Mizuki Ohama, Yukiko Morita, Noriaki Yoshida. Inhibition of 12/15-lipoxygenase reduces orthodontically induced root resorption in rats. The Angle Orthodontist. 2024. 94. 5. 566-573
Qing Jiang, Xin Qin, Takeshi Moriishi, Ryo Fukuyama, Shinichi Katsumata, Hiroshi Matsuzaki, Hisato Komori, Yuki Matsuo, Chiharu Sakane, Kosei Ito, et al. Runx2 Regulates Galnt3 and Fgf23 Expressions and Galnt3 Decelerates Osteoid Mineralization by Stabilizing Fgf23. International journal of molecular sciences. 2024. 25. 4
Takeshi Moriishi, Yosuke Kawai, Ryo Fukuyama, Yuki Matsuo, You-Wen He, Haruhiko Akiyama, Izumi Asahina, Toshihisa Komori. Bcl2l1 Deficiency in Osteoblasts Reduces the Trabecular Bone Due to Enhanced Osteoclastogenesis Likely through Osteoblast Apoptosis. International journal of molecular sciences. 2023. 24. 24

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MISC (66)：

池田悠希, 池田悠希, 森石武史, 辻麻美, 神前圭吾, 乾千珠子, 阿部真土, 前田隆史, 松下祐樹, 澤瀬隆, et al. Human pluripotent stem cell-based system recapitulating paraxial mesoderm-derived intramembranous ossification. 日本分子生物学会年会プログラム・要旨集(Web). 2023. 46th
小笹良輔, 森石武史, 小守壽文, 中野貴由. 血清中オステオカルシン濃度が骨アパタイト配向性に及ぼす影響. 日本骨形態計測学会雑誌. 2023. 33. 1. 175-175
池田悠希, 谷彰一郎, 森石武史, 黒田愛子, 松尾友紀, 乾千珠子, 阿部真土, 前田隆史, 鄭雄一, 北條宏徳, et al. ヒト多能性幹細胞による膜内骨化再現系の開発. 日本解剖学会総会・全国学術集会抄録集(CD-ROM). 2023. 128th
佛坂斉祉, 森石武史, 佛坂由可. リチウムは虚血性細胞死、硝子様変性および破歯細胞出現を抑制することで矯正力による歯根吸収を減少させる(Lithium reduces orthodontic root resorption by suppressing ischemic cell death, hyalinization, and odontoclasts formation in rats). Journal of Oral Biosciences Supplement. 2022. 2022. 334-334
小笹良輔, 森口敦, 森石武史, 小守壽文, 石本卓也, 石本卓也, 松垣あいら, 中野貴由. 骨コラーゲン/アパタイト配向性のオステオカルシン濃度依存性. 日本金属学会講演大会(Web). 2022. 170th

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Patents (2)：

Awards (1)：

2018/08 - 日本骨代謝学会第36回日本骨代謝学会学術集会優秀ポスター賞オステオカルシンはアパタイト結晶のコラーゲン線維に沿った配向に必須であり、長軸方向の骨強度を維持する

Association Membership(s) (2)：

JAPANESE ASSOCIATION FOR ORAL BIOLOGY , JAPANESE SOCIETY FOR BONE AND MINERAL RESEARCH

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