2021 - 2025 Comprehensive understanding of the enhancer cluster regulating the expression of Indian hedgehog in the skeletal system
2021 - 2024 ノックアウトマウスとレポーターマウス作製によるType I Runx2の機能解明
2021 - 2023 Investigation of the mechanism of actions of the helioxanthin-derivative and its application as a multi-kinase inhibitor
2018 - 2023 Elucidation of the mechanism in the regulation of chondrocyte-specific Runx2 enhancer and development of the drug for osteoarthritis
2018 - 2021 A study of osteocalcin-deficient mice to clarify the bone phenotypes and extraskeletal functions
2017 - 2020 Elucidation of the function of Supt3 in skeletal formation and its interaction with Runx2 promoter.
2014 - 2019 Elucidation of the transcriptional regulation of Runx2 and development of the drugs for osteoporosis and osteoarthritis
2015 - 2018 Analysis of the function of microtubule-associated protein tau (Mapt) and nestin in the formation of odontoblast processes using the genetically modified mice
2015 - 2018 Studies for expression and function of Runx2 isoforms
2015 - 2018 A study of increase bone volume using transgenic mice with osteoblasts that express proliferation and anti-apoptotic factors
2014 - 2016 Elucidation of the pathogenesis of disuse osteoporosis and steroid-induced osteoporosis using Fkbp5 knockout mice
2014 - 2015 Runx2遺伝子の軟骨細胞特異的エンハンサーの同定とその制御機構の解明
2012 - 2015 Molecular morphological examination about the formation of processes in the osteoblasts and odontoblasts
2012 - 2015 A study of mechanical stress response genes via osteocyte network
2012 - 2014 Identification and functional analysis of a novel substrate of Pdk4 in the regulation of osteoclastogenesis in the unloaded condition
2010 - 2014 The mechanism of transcriptional regulation of Runx2 gene and the program of skeletal development
2010 - 2012 アポトーシス抑制遺伝子Bcl-X_Lの骨の形成及び維持における機能解明
2010 - 2012 Functional analysis of a mechanical stress responsible geneFbxo32 on bone volume regulation
2010 - 2011 The molecule mechanism of the bone mass regulation by a bone cell network
2010 - 2011 The role of anti-apoptotic Bcl-X_L in bone formation and maintenance of bone mass
2008 - 2009 Study of osteoclast activating factor when mechanical stress changes through osteoblast controlled by osteocyte
2006 - 2008 アポトーシス抑制遺伝子Bcl-2の骨の形成および維持における機能解明
2007 - 2008 Elucidation of the mechanism of skeletal development using Runx2 and Cbfb conditional knockout mice
2006 - 2007 アポトーシス抑制遺伝子Bcl-2の骨の形成および維持における機能解明
2003 - 2004 両生類大腿骨における軟骨内骨化に関連する因子の検索
2002 - 2003 脊椎動物の進化と骨格の働きについて
2003 - 2003 両生類大腿骨における軟骨内骨化に関連する因子の検索
2002 - 2002 脊椎動物の進化と骨格の働きについて
Show all
Papers (40)：
Qing Jiang, Xin Qin, Takeshi Moriishi, Ryo Fukuyama, Shinichi Katsumata, Hiroshi Matsuzaki, Hisato Komori, Yuki Matsuo, Chiharu Sakane, Kosei Ito, et al. Runx2 Regulates Galnt3 and Fgf23 Expressions and Galnt3 Decelerates Osteoid Mineralization by Stabilizing Fgf23. International journal of molecular sciences. 2024. 25. 4
Takeshi Moriishi, Yosuke Kawai, Ryo Fukuyama, Yuki Matsuo, You-Wen He, Haruhiko Akiyama, Izumi Asahina, Toshihisa Komori. Bcl2l1 Deficiency in Osteoblasts Reduces the Trabecular Bone Due to Enhanced Osteoclastogenesis Likely through Osteoblast Apoptosis. International journal of molecular sciences. 2023. 24. 24
Hiroki Yoshioka, Sixun Wu, Takeshi Moriishi, Yosuke Tsukiboshi, Satoshi Yokota, Nobuhiko Miura, Masae Yoshikawa, Naoki Inagaki, Yuki Matsushita, Makoto Nakao. Sasa veitchii extract alleviates nonalcoholic steatohepatitis in methionine-choline deficient diet-induced mice by regulating peroxisome proliferator-activated receptor alpha. Traditional and Kampo Medicine. 2023. 10. 3. 259-268
Yuki Ikeda, Shoichiro Tani, Takeshi Moriishi, Aiko Kuroda, Yuki Matsuo, Naoya Saeki, Chizuko Inui-Yamamoto, Makoto Abe, Takashi Maeda, David W. Rowe, et al. Modeling of intramembranous ossification using human pluripotent stem cell-derived paraxial mesoderm derivatives. Regenerative Therapy. 2023. 24. 536-546
Masatoshi Murayama, Hirohito Hirata, Makoto Shiraki, Juan L Iovanna, Takayoshi Yamaza, Toshio Kukita, Toshihisa Komori, Takeshi Moriishi, Masaya Ueno, Tadatsugu Morimoto, et al. Nupr1 deficiency downregulates HtrA1, enhances SMAD1 signaling, and suppresses age-related bone loss in male mice. Journal of cellular physiology. 2023. 238. 3. 566-581
