Rchr
J-GLOBAL ID：201901015947934026   Update date: Oct. 17, 2024

Okamoto Ryo

オカモト リョウ | Okamoto Ryo
Affiliation and department：
Seikei University Faculty of Science and Technology Department of Science and Technology

About Seikei University Faculty of Science and Technology Department of Science and Technology


Research field  (4)： Bioorganic chemistry ,  Synthetic organic chemistry ,  Biochemistry ,  Chemical biology
Research keywords  (5)： glycoproteins ,  Protein chemistry ,  Peptide chemistry ,  Glycochemistry ,  hydration
Research theme for competitive and other funds  (7)：
  • 2021 - 2024 糖改変型複合糖質の迅速な系統合成法の開発と水を介した糖の複合糖質活性調節能の解明
  • 2016 - 2019 Development of the new convergent one-pot peptide ligations for the synthesis of glycoproteins and crystallography
  • 2016 - 2017 化学合成糖タンパク質を利用したシアリル糖鎖構造と糖タンパク質活性相関 の解明研究
  • 2014 - 2016 Development of a high-speed peptide synthesis in aqueous solution by using guanidides and thioesters
  • 2015 - O-結合型糖鎖の機能解明を目指した不凍糖タンパク質AFGPの立体構造解析
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Papers (59)：
  • Yasuhiro Kajihara, Yanbo Liu, Yuta Maki, Ryo Okamoto, Ayano Satoh, Yasuto Todokoro, Yurie Kanemitsu, Keito Otani. Uncovering a Latent Bioactive Interleukin-6 Glycoform. Angewandte Chemie International Edition. 2024
  • Tatsunari Akiyama, Yusuke Tanaka, Ryo Okamoto, Yasuhiro Kajihara, Masayuki Izumi. Isopeptide bond formation mediated by δ-selenolysine for chemical ubiquitination. Frontiers in Chemistry. 2023. 11
  • Yugoviandi P Mamahit, Yuta Maki, Ryo Okamoto, Yasuhiro Kajihara. Semisynthesis of homogeneous misfolded glycoprotein interleukin-8. Carbohydrate research. 2023. 531. 108847-108847
  • Kota Nomura, Ryo Okamoto, Yuta Maki, Ayumu Hayashibara, Toshifumi Takao, Tomoya Fukuoka, Eiji Miyoshi, Bradley L Pentelute, Yasuhiro Kajihara. Rapid Chemical Synthesis of Serine Protease Inhibitor Kazal-type 13 (SPINK13) Glycoform by a Combined Method with Glycan Insertion Strategy and Fast-Flow Fmoc SPPS. Chemistry (Weinheim an der Bergstrasse, Germany). 2023. 29. 42. e202300646
  • Ryo Okamoto, Ryo Orii, Hiroyuki Shibata, Yuta Maki, Sakae Tsuda, Yasuhiro Kajihara. Regulating Antifreeze Activity through Water: Latent Functions of the Sugars of Antifreeze Glycoprotein Revealed by Total Chemical Synthesis. Chemistry (Weinheim an der Bergstrasse, Germany). 2023. 29. 21. e202203553
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MISC (33)：
  • 岡本亮, 岡本亮, 真木勇太, 真木勇太, 佐藤あやの, 梶原康宏, 梶原康宏. Revisiting the function of glycans on glycoproteins in protein-protein interaction. 日本糖質学会年会要旨集. 2022. 41st
  • 佐藤あやの, 真木勇太, 川田一稀, 岡本亮, 梶原康宏. 糖タンパク質の細胞内逆行輸送の定量化. 日本生化学会大会(Web). 2022. 95th
  • 西川晴美, 上田南, 真木勇太, 真木勇太, 岡本亮, 岡本亮, 和泉雅之, 梶原康宏, 梶原康宏. Glycopeptide synthesis for construction of quaternary structure of IgG antibody Fc region. 日本糖質学会年会要旨集. 2022. 41st
  • 真木勇太, 佐藤あやの, 川田一希, 岡本亮, 梶原康宏. Chemical synthesis of glycosylated Cholera toxin B-subunit and its delivering into living cells. 日本糖質学会年会要旨集. 2021. 40th
  • 野村幸汰, 真木勇太, 真木勇太, 岡本亮, 岡本亮, 佐藤あやの, 梶原康宏, 梶原康宏. Homogeneous Glycoprotein Synthesis by Chemical Insertion of Glycan. 日本糖質学会年会要旨集. 2021. 40th
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Patents (4)：
Lectures and oral presentations  (20)：
  • 化学合成糖タンパク質を利用し糖鎖の水和機能を探る
    (大阪大学蛋白質研究所セミナー、蛋白質に挑戦する化学 2023)
  • Dissecting the hydration of glycans on proteins by using total chemical synthesis of glycoproteins
    (International Congress on Pure & Applied Chemistry 2022)
  • 非天然型糖タンパク質を合成し天然型糖鎖の機能を探る
    (第8回慶應有機化学若手シンポジウム 2021)
  • 化学合成不凍糖タンパク質を利用したタンパク質糖鎖修飾機能の解明研究
    (第61回 天然有機化合物討論会 2019)
  • 化学合成不凍糖タンパク質を利用したタンパク質糖鎖修飾機能の解明研究
    (第38回日本糖質学会 2019)
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Education (3)：
  • 2006 - 2009 Yokoham City University
  • 2004 - 2006 Yokohama City University
  • 2000 - 2004 Yokohama City University School of Science
Professional career (1)：
  • 博士(理学) (横浜市立大学)
Work history (6)：
  • 2024/04 - 現在 Seikei University Faculty of Science and Technology, Department of Science and Technology Associate Professor
  • 2023/08 - 2024/03 Osaka University Graduate School of Science Associate Professor
  • 2017/07 - 2023/07 Osaka University Department of Chemistry, Graduate School of Science Associate Professor
  • 2010/09 - 2017/06 Osaka University Department of Chemistry, Graduate of School Assistant Professor
  • 2009/08 - 2010/08 JSPS Postdoctoral Fellow for Research Abroad
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Committee career (2)：
  • 2022/06 - 現在 Review Editor on the Editorial Board of Chemical Biology
  • 2018 - 現在 International Journal of Peptide Research and Therapeutics Editorial board
Awards (3)：
  • 2015 - Japanese Society of Carbohydrate Research Incentive Award of Japanese Society of Carbohydrate Research
  • 2012 - Chemical Society of Japan Chemical Society of Japan Presentation Award 2012
  • 2009 - 日本糖質学会 日本糖質学会第12回ポスター賞
Association Membership(s) (2)：
THE CHEMICAL SOCIETY OF JAPAN ,  THE JAPANESE SOCIETY OF CARBOHYDRATE RESEARCH
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