Rchr
J-GLOBAL ID：201901016616283846
Update date: Aug. 20, 2024
Yamauchi Motohiro
Yamauchi Motohiro
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Research field (2)：
Environmental effects of chemicals
, Environmental effects of radiation
Research keywords (4)：
Chromosome aberration
, DNA damage response
, DNA repair
, Radiation
Research theme for competitive and other funds (10)：
2022 - 2025 Does phase separation of DNA double-strand break repair factors promote chromosome rearrangement?
2021 - 2025 全ゲノム領域に共通した正確なDNA修復を保証するDSB修復経路選択機構の研究
2020 - 2022 遺伝子領域間に引き起こされる転写共役型染色体転座経路の解明
2018 - 2021 DNA二本鎖切断同士のペアリングを制御する分子ネットワークの解明
2016 - 2019 Creation of Radiation Science Culture with High Robustness - A New Horizon of Radiation Learning
2015 - 2018 Analysis of individual fate determination of irradiated cells by using live cell imaging technique
2015 - 2018 Proof of mutual interference between two DNA double strand break sites leading to chromosomal translocation
2015 - 2018 CRISPR/Cas9を用いた癌関連融合遺伝子の生成・生成抑制機構の解明
2012 - 2015 放射線照射後の染色体転座形成および形成抑制の分子機構の解明
2009 - 2012 Foci on FISH法を用いた染色体転座によるATM持続的活性化の証明
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Papers (48)：
Kie Ozaki, Reona Kato, Takaaki Yasuhara, Yuki Uchihara, Miyako Hirakawa, Yu Abe, Hiroki Shibata, Reika Kawabata-Iwakawa, Aizhan Shakayeva, Palina Kot, et al. Involvement of the splicing factor SART1 in the BRCA1-dependent homologous recombination repair of DNA double-strand breaks. Scientific Reports. 2024. 14. 1
Ryota Hayashi, Hikaru Okumura, Mayu Isono, Motohiro Yamauchi, Daiki Unami, Rahmartani Tania Lusi, Masamichi Yamamoto, Yu Kato, Yuki Uchihara, Atsushi Shibata. Inhibition of intracellular ATP synthesis impairs the recruitment of homologous recombination factors after ionizing radiation. Journal of radiation research. 2024
Yuki Uchihara, Tiara Bunga Mayang Permata, Hiro Sato, Reika Kawabata-Iwakawa, Sayako Katada, Wenchao Gu, Sangeeta Kakoti, Motohiro Yamauchi, Reona Kato, Soehartati Gondhowiardjo, et al. DNA damage promotes HLA class I presentation by stimulating a pioneer round of translation-associated antigen production. Molecular cell. 2022. 82. 14. 1-14
Takaaki Yasuhara, Reona Kato, Motohiro Yamauchi, Yuki Uchihara, Lee Zou, Kiyoshi Miyagawa, Atsushi Shibata. RAP80 suppresses the vulnerability of R-loops during DNA double-strand break repair. Cell Reports. 2022. 38. 5. 110335-110335
Eiko Inamasu, Tomoshi Tsuchiya, Motohiro Yamauchi, Kodai Nishi, Katsuya Matsuda, Fumio Sugawara, Kengo Sakaguchi, Ryoichi Mori, Keitaro Matsumoto, Takuro Miyazaki, et al. Anticancer agent α-sulfoquinovosyl-acylpropanediol enhances the radiosensitivity of human malignant mesothelioma in nude mouse models. Journal of radiation research. 2022. 63. 1. 19-29
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MISC (11)：
Takeshi Fuchigami, Natsumi Ishikawa, Iori Nozaki, Yusuke Miyanari, Sakura Yoshida, Motohiro Yamauchi, Ayumi Soejima, Mamoru Haratake, Morio Nakayama. Discovery of INCENP-derived small peptides for cancer imaging and treatment targeting survivin. Cancer science. 2020
山内基弘, 柴田淳史, 鈴木啓司, 鈴木正敏, 新美敦子, 近藤久義, 三浦美和, 平川美弥子, 辻田啓子, 山下俊一, et al. 放射線照射によって生じたDNA二本鎖切断同士のペアリングの制御機構. 日本保健物理学会研究発表会講演要旨集. 2017. 50th. 103
西弘大, 松田尚樹, 松田尚樹, 山内基弘, 山内基弘, 折田真紀子, 高村昇, 工藤崇. 看護師を対象とした放射線教育プログラムの新展開. 日本放射線安全管理学会学術大会講演予稿集. 2016. 15th. 69
山内基弘, 柴田淳史, 鈴木啓司, 鈴木正敏, 新美敦子, 近藤久義, 三浦美和, 平川美弥子, 山下俊一, 松田尚樹. ATMとDNA-PKによるDNA二本鎖切断同士の会合の抑制. 原子爆弾後障害研究会特集号. 2016. 57th. 184-186
山内 基弘, 柴田 淳史, 鈴木 啓司, 鈴木 正敏, 新美 敦子, 近藤 久義, 三浦 美和, 平川 美弥子, 山下 俊一, 松田 尚樹. ATMとDNA-PKによるDNA二本鎖切断同士の会合の抑制 (特集 第57回原子爆弾後障害研究会講演集). 長崎医学会雑誌. 2016. 91. 184-186
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Books (1)：
放射線と安全につきあう : 利用の基礎と実際
名古屋大学出版会 2017 ISBN:9784815808754
Professional career (1)：
博士(医学) (長崎大学)
Awards (1)：
2020/11 - 日本アイソトープ協会 放射線安全管理奨励賞
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