Akimoto Miho

Affiliation and department：

Research field (2)： Cell biology , Tumor biology

Research keywords (2)：腫瘍生物学 , 細胞生物学

Research theme for competitive and other funds (5)：

2022 - 2025 肥満および老化の脂肪幹細胞由来のIL-33が膵がんの悪性進展に及ぼす影響の解析
2019 - 2023 低酸素による可溶性IL-33受容体の発現低下が大腸がん悪性進展に及ぼす影響の解析
2017 - 2023 Expression of Parathyroid-specific Novel lncRNA and Paucity of CaSR Characterize an Ectopic PTH-producing Tumor.
2016 - 2020 Analysis of antitumor effects of adiponectin receptor agonists on pancreatic cancer
2012 - 2015 Antimetastatic effects of a soluble IL-33 receptor and its utility as a prognostic biomarker in colorectal cancer.

Papers (26)：

Noriyuki Okudaira, Mi-Ho Akimoto, Takao Susa, Miho Akimoto, Harumi Hisaki, Masayoshi Iizuka, Hiroko Okinaga, Julio A Almunia, Noboru Ogiso, Tomoki Okazaki, et al. Accumulation of senescent cells in the adrenal gland induces hypersecretion of corticosterone via IL1β secretion. Aging cell. 2024. e14206
Miho Akimoto, Takao Susa, Noriyuki Okudaira, Nobuko Koshikawa, Harumi Hisaki, Masayoshi Iizuka, Hiroko Okinaga, Keizo Takenaga, Tomoki Okazaki, Mimi Tamamori-Adachi. Hypoxia induces downregulation of the tumor-suppressive sST2 in colorectal cancer cells via the HIF-nuclear IL-33-GATA3 pathway. Proceedings of the National Academy of Sciences of the United States of America. 2023. 120. 18. e2218033120
Miho Akimoto, Takao Susa, Noriyuki Okudaira, Harumi Hisaki, Masayoshi Iizuka, Hiroko Okinaga, Tomoki Okazaki, Mimi Tamamori-Adachi. A Novel LncRNA PTH-AS Upregulates Interferon-Related DNA damage resistance Signature genes and Promotes Metastasis in Human Breast Cancer Xenografts. Journal of Biological Chemistry. 2022. 102065-102065
Keizo Takenaga, Nobuko Koshikawa, Miho Akimoto, Yasutoshi Tatsumi, Jason Lin, Makiko Itami, Hiroki Nagase. MCT4 is induced by metastasis-enhancing pathogenic mitochondrial NADH dehydrogenase gene mutations and can be a therapeutic target. Scientific reports. 2021. 11. 1. 13302-13302
Keizo Takenaga, Miho Akimoto, Nobuko Koshikawa, Hiroki Nagase. Obesity reduces the anticancer effect of AdipoRon against orthotopic pancreatic cancer in diet-induced obese mice. Scientific reports. 2021. 11. 1. 2923-2923

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MISC (7)：

奥平准之, 秋元美穂, 諏佐崇生, 秋元美穂, 小原幸弘, 久樹晴美, 飯塚眞由, 岡崎具樹, 安達(玉盛)三美. Mechanisms of adrenal aging and enhancement of the Glucocorticoid-system. 日本分子生物学会年会プログラム・要旨集(Web). 2022. 45th
小原幸弘, 諏佐崇生, 秋元美穂, 奥平准之, 久樹晴美, 飯塚眞由, 岡崎具樹, 安達三美. Dynamic expression changes of energy metabolism-related genes in mouse liver with aging. 日本分子生物学会年会プログラム・要旨集(Web). 2022. 45th
HARASHIMA Nanae, AKIMOTO Miho, TAKENAGA Keizo, HARADA Mamoru. HIF-2α regulates susceptibility of human pancreatic cancer cells to TRAIL- and T cell-mediated cytotoxicity via survivin. 日本癌学会学術総会抄録集(Web). 2015. 74th. E-1238 (WEB ONLY)
HARASHIMA Nanae, HARI Yoko, MONMA Hiroyuki, AKIMOTO Miho, TAKENAGA Keizo, TAJIMA Yoshitsugu, HARADA Mamoru. Inhibition of HIF-2αsensitizes human pancreatic cancer cells to TRAIL. 日本癌学会学術総会抄録集(Web). 2014. 73rd. E-3032 (WEB ONLY)
Yoshio Honma, Miho Akimoto, Keizo Takenaga, Takeshi Sassa, Nobuo Kato. Augmenting sensitivity of cancer cells to novel antitumor fusicoccin derivative (ISIR-042) by hypoxia. MOLECULAR CANCER THERAPEUTICS. 2009. 8. 12

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Work history (2)：

2017/07 - 現在 Teikyo University School of Medicine
2006/05 - 2017/06 Shimane University Faculty of Medicine

Association Membership(s) (2)：

日本分子生物学会 , THE JAPANESE CANCER ASSOCIATION

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