Sanae Hayashi

Affiliation and department：

Research field (3)： Virology , Gastroenterology , Home economics, lifestyle science

Research keywords (6)：消化器内科学 , 肝臓病学 , 肝炎ウイルス , B型肝炎 , 動脈硬化 , メタボリックシンドローム

Research theme for competitive and other funds (4)：

2023 - 2026 核酸アナログ耐性機序の解明及び多剤耐性HBVに有効な新規治療薬の開発
2020 - 2023 テノホビル(TDF)に対する新規耐性HBVの同定と耐性メカニズムの解明
2016 - 2018 Elucidating the mechanism of ameliorated liver disease and HBs antigen elimination by nucleos(t)ide analogs in chronic hepatitis B patients
2015 - 2016 B型慢性肝炎に対する新規免疫治療の探索

Papers (22)：

Kosaku Kitagawa, Kwang Su Kim, Masashi Iwamoto, Sanae Hayashi, Hyeongki Park, Takara Nishiyama, Naotoshi Nakamura, Yasuhisa Fujita, Shinji Nakaoka, Kazuyuki Aihara, et al. Multiscale modeling of HBV infection integrating intra- and intercellular viral propagation for analyzing extracellular viral markers. PLOS Computational Biology. 2024
Takehisa Watanabe, Sanae Hayashi, Yan Zhaoyu, Hiroki Inada, Katsuya Nagaoka, Masakuni Tateyama, Yasuhito Tanaka. A novel, small anti-HBV compound reduces HBsAg and HBV-DNA by destabilizing HBV-RNA. Journal of gastroenterology. 2024
Hiroki Kumamoto, Nobuyo Higashi-Kuwata, Sanae Hayashi, Debananda Das, Haydar Bulut, Ryoh Tokuda, Shuhei Imoto, Kengo Onitsuka, Yuka Honda, Yuki Odanaka, et al. Synthesis of novel entecavir analogues having 4'-cyano-6''-fluoromethylenecyclopentene skeletons as an aglycone moiety as highly potent and long-acting anti-hepatitis B virus agent. RSC advances. 2023. 13. 23. 15999-16011
Yuki Takamatsu, Sanae Hayashi, Hiroki Kumamoto, Shuhei Imoto, Yasuhito Tanaka, Hiroaki Mitsuya, Nobuyo Higashi-Kuwata. A Novel Anti-HBV Agent, E-CFCP, restores Hepatitis B virus (HBV)-induced Senescence-associated Cellular Markers Perturbation in Human Hepatocytes. Virus research. 2023. 329. 199094-199094
Anna Nakanishi, Hiroki Okumura, Tadahiro Hashita, Aya Yamashita, Yuka Nishimura, Chihiro Watanabe, Sakina Kamimura, Sanae Hayashi, Shuko Murakami, Kyoko Ito, et al. Ivermectin Inhibits HBV Entry into the Nucleus by Suppressing KPNA2. Viruses. 2022. 14. 11. 2468-2468

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MISC (32)：

渡邊丈久, 林佐奈衣, 田中靖人. B型肝炎診療の未来予想図(現状と課題) HBV-RNAを標的とする新規抗HBV化合物SAGを用いた併用療法の有効性. 肝臓. 2023. 64. Suppl.1. A54-A54
林佐奈衣, 鍬田伸好, 田中靖人, 満屋裕明. PXBマウス誘導E-CFCP耐性株の耐性度は既知NA耐性変異株に比べて低い. 肝臓. 2023. 64. Suppl.1. A415-A415
渡邊丈久, 林佐奈衣, 田中靖人. B型肝炎診療の現状と今後の展開 HBV-RNA結合蛋白を介した新規HBV経口治療薬SAG化合物の作用点. 肝臓. 2022. 63. Suppl.2. A496-A496
長岡克弥, 楢原哲史, 林佐奈衣, 稲田浩気, 田中健太郎, 蔵野宗太郎, 徳永尭之, 吉丸洋子, 渡邊丈久, 瀬戸山博子, et al. ソラフェニブ耐性肝癌細胞におけるエピゲノム薬による耐性克服. 肝臓. 2022. 63. Suppl.2. A565-A565
林佐奈衣, 榎本大, 松浦健太郎, 井出達也, 松居剛志, 髭修平, 榎本平之, 渡邊丈久, 長岡克弥, 立山雅邦, et al. 核酸アナログ多剤耐性例のウイルス学的特徴. 肝臓. 2022. 63. Suppl.2. A604-A604

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Education (3)：

2012 - 2015 Nagoya City University Graduate School of Medical Sciences
2006 - 2008 Sugiyama Jogakuen University
2002 - 2006 Sugiyama Jogakuen University School of Life Studies (Seikatsuka Gakubu)

Professional career (1)：

医学博士 (名古屋市立大学)

Work history (3)：

2021/01 - 現在 Kumamoto University
2011/04 - 現在 Nagoya City University
2008/04 - 2011/03 Sugiyama Jogakuen University School of Life Studies (Seikatsuka Gakubu), Department of Human Nutrition

Awards (11)：

2019/11 - 日本肝臓学会第4回Gilead Sciences Award B型肝炎コアウイルス変異の蓄積による肝発癌メカニズムの解明と臨床応用
2019/10 - Hepatitis B Foundation 2019 HBV Meeting Travel Grant award Hepatitis B virus cccDNA is stable during hepatocyte proliferation in vivo.
2018/10 - 2018 HBV Meeting Travel Grant award Highly accurate quantification of intrahepatic Hepatitis B virus cccDNA by droplet digital PCR.
2018/05 - APASL STC Young Investigator Award A novel association between core mutations in hepatitis B virus genotype F1b and hepatocellular carcinoma in Alaskan Native People.
2017/05 - 第27回抗ウイルス療法学会総会塩田賞 Entecavirよりも持続的かつ強力に抗HBV活性を有する新規核酸アナログCFCPの同定

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Association Membership(s) (3)：

熊本医学会 , 抗ウイルス療法学会 , The Japan Society of Hepatology

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