Sho Aki

Affiliation and department：

Research field (3)： Cell biology , Physiology , Tumor biology

Research keywords (6)：ホスホイノシタイド , ミトコンドリア , オルガネラ , エンドサイトーシス , 細胞内小胞輸送 , 血管新生

Research theme for competitive and other funds (5)：

2024 - 2027 The mechanism of mitochondrial dynamics regulation via PIPs
2020 - 2023 II型PI3キナーゼによるメンブレントラフィック制御を介した心臓・血管の機能調節
2018 - 2020 New mechanisms of perinatal cardiovascular regulation by class II PI3K
2016 - 2018 Class II PI3K regulate receptor endocytosis and endosomal signaling
2014 - 2017 Regulation of membrane trafficking through PI(3)P-metabolizing enzymes in endothelial cells.

Papers (19)：

Juri Sakata, Toshifumi Tatsumi, Akira Sugiyama, Akihiro Shimizu, Yuya Inagaki, Hiroto Katoh, Takefumi Yamashita, Kazuki Takahashi, Sho Aki, Yudai Kaneko, et al. Antibody-mimetic drug conjugate with efficient internalization activity using anti-HER2 VHH and duocarmycin. Protein Expression and Purification. 2024. 214. 106375-106375
Ryuichi Nakahara, Sho Aki, Maki Sugaya, Haruka Hirose, Miki Kato, Keisuke Maeda, Daichi M Sakamoto, Yasuhiro Kojima, Miyuki Nishida, Ritsuko Ando, et al. Hypoxia activates SREBP2 through Golgi disassembly in bone marrow-derived monocytes for enhanced tumor growth. The EMBO journal. 2023. 42. 22. e114032
Miki Kato, Keisuke Maeda, Ryuichi Nakahara, Haruka Hirose, Ayano Kondo, Sho Aki, Maki Sugaya, Sana Hibino, Miyuki Nishida, Manami Hasegawa, et al. Acidic extracellular pH drives accumulation of N1-acetylspermidine and recruitment of protumor neutrophils. PNAS nexus. 2023. 2. 10. pgad306
Akihiro Kitagawa, Tsuyoshi Osawa, Miwa Noda, Yuta Kobayashi, Sho Aki, Yusuke Nakano, Tomoko Saito, Dai Shimizu, Hisateru Komatsu, Maki Sugaya, et al. Convergent genomic diversity and novel BCAA metabolism in intrahepatic cholangiocarcinoma. British journal of cancer. 2023. 128. 12. 2206-2217
Sho Aki, Ryuichi Nakahara, Keisuke Maeda, Tsuyoshi Osawa. Cancer metabolism within tumor microenvironments. Biochimica et biophysica acta. General subjects. 2023. 1867. 5. 130330-130330

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MISC (12)：

安藝翔, 大澤毅. Understanding cell-cell to cell-organelle to organelle mediated diseases. 実験医学. 2023. 41. 15
安藝翔. クラスII PI3K はエンドサイトーシスを制御して血管新生に関与する. 月刊「細胞」特集 : 血管のバイオロジー. 2018
西田洋児, 安藝翔, 山本宜孝, 加藤寛城, 飯野賢治, 木村圭一, 多久和陽, 竹村博文. 内胸動脈グラフトの血管攣縮に対するRho-kinase inhibitor(Fasudil)の抗攣縮効果. 日本外科学会定期学術集会(Web). 2018. 118th. ROMBUNNO.PS-196-3 (WEB ONLY)
Phosphatidylinositol 3-kinase class IIα-isoform PI3K-C2α is required for transforming growth factor β-induced Smad signaling in endothelial cells. 2016. 125. 2. 73-74
Saori Koizumi, Kazuaki Yoshioka, Sho Aki, Yoh Takuwa. Phosphatidylinositol 3-kinase class II α isoform (PI3K-C2α) maintains vascular integrity. The Juzen Medical Society Kanazawa University. 2016. 125. 2. 77-78

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Work history (2)：

Committee career (2)：

Awards (11)：

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