2021 - 2024 Establishment of high-precision intraoperative rapid diagnostic method by new biological observation method for Hirschsprung's disease-related diseases
2021 - 2024 Intestinal Organoid transplantation in pediatric IBD patients
2020 - 2023 胆道閉鎖症における肝門部微小胆管の二光子レーザー顕微鏡による観察研究
2019 - 2022 Analysis for the intestinal enteric nervous system of Hirschsprung disease patients by the novel intravital fluorescent observation method
2017 - 2020 Pathophysiological analysis and treatment strategy for necrotizign colitis by realtime observation of intestinal microcirculation
2013 - 2016 Intravital imaging of microcirculation on murine sepsis model using two-photon laser scanning microscopy
2011 - 2012 Breakthrough of the pathogenesis and treatment strategy in necrotizing enterocolitis using two-photon laser scanning microscopy based on the alarmin concept.
2009 - 2010 Research of pathogenesis and treatment of the necrotizing enterocolitis model induced by in vivo real-time two-photon microscopic imaging
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Papers (234):
Yuhki Koike, Koki Higashi, Yuki Sato, Shinji Yamashita, Yuka Nagano, Tadanobu Shimura, Takahito Kitajima, Kohei Matsushita, Yoshinaga Okugawa, Yoshiki Okita, et al. Preventive effect of Clostridium butyricum MIYAIRI against pouchitis in children with ulcerative colitis. Surgery today. 2024
Yuhki Koike, Yuki Sato, Koki Higashi, Yuka Nagano, Shimura Tadanobu, Takahito Kitajima, Kohei Matsushita, Yoshinaga Okugawa, Akira Mizoguchi, Yuji Toiyama. Dynamic pathology in various disease-model mice using multiphoton laser scanning microscopy. Journal of Pediatric Surgery Open. 2024. 8. 100125-100125
Yuhki Koike, Akira Mizoguchi, Keiichi Uchida, Yuki Sato, Koki Higashi, Yuka Nagano, Kohei Matsushita, Kousyoku Sai, Aika Kaito-Yamagishi, Shujie Wang, et al. Dynamic Pathology of Enteric Neural Network using Curcumin-assisted Multiphoton Laser Imaging in Hirschsprung Disease. Annals of surgery. 2024
2023/05 - 三重大学優秀論文・著書・作品賞 Remote ischemic conditioning counteracts the intestinal damage of necrotizing enterocolitis by improving intestinal microcirculation. Nature Communications
2021/10 - Young Investigator Award Remote ischemic conditioning counteracts the intestinal damage of necrotizing enterocolitis by improving intestinal microcirculation. Nature communications. Oct 2;11(1):4950:2020
2020/12 - Medical Award of Mie University Remote ischemic conditioning counteracts the intestinal damage of necrotizing enterocolitis by improving intestinal microcirculation.
2014/09 - International Symposium on Paediatric Surgical Research The 27th International Symposium on Paediatric Surgical Research Third prize Dynamic pathology for circulating free DNA in dextran sodium sulfate colitis mice model