Mizuno Natsumi

Research field (3)： Pathobiochemistry , Pharmacology , Medical biochemistry

Research keywords (5)：受容体シグナル , inflammation , macrophage , dendritic cells , Antigen-presenting cells (APCs)

Research theme for competitive and other funds (4)：

2022 - 2025 組織修復型マクロファージの新しい誘導法とその応用
2019 - 2021 New pharmacological effect of tofacitinib via modulating macrophage function
2014 - 2016 Elucidation of mechanism of the protection against allergies by LPS
2013 - 2015 胸腺間質リンパ球増殖因子受容体オリゴマー化がアレルギー誘発に及ぼす影響の解明

Papers (26)：

Natsumi Mizuno, Saki Shiga, Yoshiyuki Tanaka, Tatsuki Kimura, Yoshiki Yanagawa. CDK8/19 inhibitor enhances arginase-1 expression in macrophages via STAT6 and p38 MAPK activation. European journal of pharmacology. 2024. 176852-176852
Natsumi Mizuno, Yoshiki Yanagawa. Tofacitinib enhances interferon-γ-induced expression of major histocompatibility complex class II in macrophages. European journal of pharmacology. 2021. 174564-174564
Tomoko Hinse Endo, Natsumi Mizuno, Saeko Matsuda, Saki Shiga, Yoshiki Yanagawa. Synergy of interleukin-4 and interferon-γ in arginase-1 production in RAW264.7 macrophages. Asian Pacific journal of allergy and immunology. 2021
Ryosuke Segawa, Mika Shiraki, Shiori Sudo, Kenichi Shigeeda, Taiji Saito, Natsumi Mizuno, Takahiro Moriya, Takayuki Yonezawa, Je-Tae Woo, Masahiro Hiratsuka, et al. A chalcone derivative suppresses the induction of TSLP in mice and human keratinocytes and attenuates OVA-induced antibody production in mice. European journal of pharmacology. 2019. 851. 52-62
Naoyuki Tashiro, Ryosuke Segawa, Ryozo Tobita, Sanki Asakawa, Natsumi Mizuno, Masahiro Hiratsuka, Noriyasu Hirasawa. Hypoxia inhibits TNF-α-induced TSLP expression in keratinocytes. PloS one. 2019. 14. 11. e0224705

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Lectures and oral presentations (31)：

CDK8/19阻害薬によるIL-4誘導性アルギナーゼ1発現の増加
(日本薬学会第144年会 2024)
IFN-γ前処理によるM2マクロファージの誘導促進とそのメカニズム Enhanced M2-polarization of IFN-g-primed macrophages in response to IL-4
(日本薬学会第144年会 2024)
Effect of CDK8/19 inhibition on IL-4-induced arginase-1 expression in macrophages.
(第97回日本薬理学会年会 2023)
M2様マクロファージの新規誘導法とそのメカニズム
(第74回日本薬理学会北部会 2023)
マクロファージ貪食能におけるCD206発現変化の影響
(日本薬学会北海道支部第150回例会 2023)

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Education (1)：

Work history (6)：

2019 - 現在 Health Sciences University of Hokkaido Faculty of Pharmaceutical Sciences
2018 - 2019 グラクソ・スミスクライン株式会社開発本部
2016/04 - 2018/03 独立行政法人国立病院機構仙台医療センター附属仙台看護助産学校非常勤講師
2015 - 2018 Tohoku University Graduate School of Pharmaceutical Sciences
2014 - 2015 University of Toyama Graduate School of Medicine and Pharmaceutical Sciences for Research

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Awards (1)：

Association Membership(s) (3)：

日本薬学会 , 日本免疫学会 , 日本薬理学会

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