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J-GLOBAL ID：201901019985209535 Update date: Oct. 14, 2024

Koga Keisuke

コガケイスケ | Koga Keisuke

Affiliation and department：

Research field (1)： Neuroscience - general

Research keywords (5)： neural circuits , patch-clamp recording , somatosensory system , spinal dorsal horn , pain

Research theme for competitive and other funds (3)：

2022 - 2024 神経回路特異的遺伝子操作による2つの下行性疼痛制御系の相互作用解析
2020 - 2022 Investigation of serotonergic modulation of spinal dorsal horn neurons by cell-type specific genome editing.
2017 - 2019 Investigation of spinal circuit mechanisms for itch sensitization in chronic itch conditions via activated spinal astrocytes

Papers (19)：

Eiji Shigetomi, Hideaki Suzuki, Yukiho J. Hirayama, Fumikazu Sano, Yuki Nagai, Kohei Yoshihara, Keisuke Koga, Toru Tateoka, Hideyuki Yoshioka, Youichi Shinozaki, et al. Disease-relevant upregulation of P2Y1 receptor in astrocytes enhances neuronal excitability via IGFBP2. Nature Communications. 2024. 15. 1
Keisuke Koga, Kenta Kobayashi, Makoto Tsuda, Anthony E. Pickering, Hidemasa Furue. Anterior cingulate cross-hemispheric inhibition via the claustrum resolves painful sensory conflict. Communications Biology. 2024. 7. 1
Yuka Fujiwara, Keisuke Koga, Nozomu H. Nakamura, Keishi Maruo, Toshiya Tachibana, Hidemasa Furue. Optogenetic inhibition of spinal inhibitory neurons facilitates mechanical responses of spinal wide dynamic range neurons and causes mechanical hypersensitivity. Neuropharmacology. 2024. 242. 109763-109763
Keisuke Koga, Kenta Kobayashi, Makoto Tsuda, Kazufumi Kubota, Yutaka Kitano, Hidemasa Furue. Voltage-gated calcium channel subunit α2δ-1 in spinal dorsal horn neurons contributes to aberrant excitatory synaptic transmission and mechanical hypersensitivity after peripheral nerve injury. Frontiers in Molecular Neuroscience. 2023. 16
Tadayuki Ishibashi, Daichi Sueto, Yu Yoshikawa, Keisuke Koga, Ken Yamaura, Makoto Tsuda. Identification of Spinal Inhibitory Interneurons Required for Attenuating Effect of Duloxetine on Neuropathic Allodynia-like Signs in Rats. Cells. 2022. 11. 24

MISC (2)：

石橋忠幸, 石橋忠幸, 山浦健, 古賀啓祐, 津田誠. ノルアドレナリンによる脊髄後角表層神経サブセットの活性化. 日本麻酔科学会学術集会(Web). 2021. 68th
古賀啓祐, 兼久賢章, 高露雄太, 齋藤秀俊, 井上和秀, 古江秀昌, 津田誠. 脊髄後角抑制性介在神経の急性的な抑制はモルヒネ抵抗性の自発的疼痛関連行動を引き起こす. Pain Research. 2017. 32. 2. 120-120

Lectures and oral presentations (12)：

The role of anterior cingulate cross-hemispheric projection to the claustrum in pain processing
(Neuro2024 2024)
Anterior cingulate cross-hemispheric projection to the claustrum determines prioritization in painful sensory conflict
(FENS forum 2024 2024)
脊髄後角興奮性神経に発現するα2δ-1サブユニットの機械性痛覚過敏における役割解明
(第101回日本生理学会大会 2024)
疼痛制御に関与する新たな中枢神経機構の探索と役割解明
(痛み研究会2023 2024)
光遺伝学的脊髄GABAニューロンの脱抑制による異常痛覚応答とα2δ-1リガンドによる鎮痛効果
(第45回日本疼痛学会 2023)

Education (2)：

Professional career (1)：

Work history (4)：

2020/04 - 現在 Hyogo Medical University Department of Neurophysiology Assistant professor
2019/04 - 2020/03 Kyushu University, Graduate school of Pharmacological Sciences Department of Life Innovation Temporally appointed assistant professor
2018/04 - 2019/03 Japan Society for the Promotion of Science JSPS reserch fellow (PD, switch from DC2)
2017/04 - 2018/03 Japan Society for the Promotion of Science JSPS reserch fellow (DC2)

Awards (2)：

2019/03 - The 92nd Annual Meeting Excellent Presentation Award Spinal dorsal horn astrogliosis facilitates itch transmission in a mouse model of contact dermatitis
2018/03 - 九州大学九州大学学位記授与式における学術研究活動表彰

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