Hinohara Kunihiko

ヒノハラクニヒコ | Hinohara Kunihiko

Affiliation and department：
Job title： Designated associate professor

Research field (2)： Molecular biology , Tumor biology

Research keywords (10)：非コード領域 , 細胞進化軌跡 , がん細胞不均一性 , 細胞系譜追跡 , 細胞可塑性 , 細胞多様性 , tumor evolution , synthetic lethality , epigenetics , tumor heterogeneity

Research theme for competitive and other funds (9)：

2024 - 2027 CRISPRタイリングスクリーンを用いたがん分子標的の機能性ドメイン探索と機能解析
2023 - 2026 がん薬剤耐性化におけるパーシスター細胞の運命決定機構
2022 - 2025 がん免疫療法における耐性化機序と進化軌跡の解明
2020 - 2024 エピゲノムダイナミクスに基づくがん多様性の新たな理解
2020 - 2023 The evolutional trajection and precision-medicine to gliomas

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Papers (20)：

Komine, O, Ohnuma, S, Hinohara, K, Hara, Y, Shimada, M, Akashi, T, Watanabe, S, Sobue, A, Kawade, N, Ogi, T, et al. Genetic background variation impacts microglial heterogeneity and disease progression in amyotrophic lateral sclerosis model mice. ISCIENCE. 2024. 27. 2. 108872
Xiao, MR, Kondo, S, Nomura, M, Kato, S, Nishimura, K, Zang, WJ, Zhang, YF, Akashi, T, Viny, A, Shigehiro, T, et al. BRD9 determines the cell fate of hematopoietic stem cells by regulating chromatin state. NATURE COMMUNICATIONS. 2023. 14. 1. 8372
Sugiyama, D, Hinohara, K, Nishikawa, H. Significance of regulatory T cells in cancer immunology and immunotherapy. EXPERIMENTAL DERMATOLOGY. 2023. 32. 3. 256-263
Kato, S, Maeda, Y, Sugiyama, D, Watanabe, K, Nishikawa, H, Hinohara, K. The cancer epigenome: Non-cell autonomous player in tumor immunity. CANCER SCIENCE. 2023. 114. 3. 730-740
Tsujino, T, Takai, T, Hinohara, K, Gui, F, Tsutsumi, T, Bai, X, Miao, CK, Feng, C, Gui, B, Sztupinszki, Z, et al. CRISPR screens reveal genetic determinants of PARP inhibitor sensitivity and resistance in prostate cancer. NATURE COMMUNICATIONS. 2023. 14. 1. 252

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Education (2)：

2006 - 2009 Tokyo Medical and Dental University Biomedical Science PhD Program
- 2004 Tokyo University of Science Faculty of Science Department of Applied Chemistry

Professional career (1)：

Ph.D. (Tokyo Medical and Dental University)

Work history (7)：

2019/07 - 現在 Nagoya University Department of Immunology, Graduate School of Medicine/Institute for Advanced Research Designated associate professor
2019/07 - 現在 Nagoya University Institute for Advanced Research Designated associate professor
2019/07/01 - 現在 Nagoya University Graduate School of Medicine Program in Integrated Medicine Microbiology and Immunology Designated associate professor
2014/04 - 2019/06 Dana-Farber Cancer Institute Medical Oncology Research fellow
2012/04 - 2014/03 The University of Tokyo Division of Molecular Therapy, Institute for Medical Science Designated assistant professor

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