Research theme for competitive and other funds (5):
2017 - 2021 Elucidation of network in damaged liver involved by novel modification form of D-dopachrome tautomerase
2010 - 2011 Comprehensive analysis of the tyrosine metabolic enzymes included in the candidates of liver protection pathways
2008 - 2010 Evaluation of the postmenopausal ovarian function in hospital based case-control study
2008 - 2010 Molecular epidemiologic study on the health effects of exposure to environmental cadmium
2006 - 2007 Exploration of new biological marker of the health effects caused by environmental pollutants using genomic and proteomic analyses
Papers (57):
Hara N, Osago H, Hiyoshi M, Kobayashi-Miura M. The Rate of NAD+ Breakdown Is Maintained Constant against Deletion or Overexpression of NAD+-Degrading Enzymes in Mammalian Cells. J Nutr Sci Vitaminol. 2024. 70. 4. 295-304
Kono M, Osago H, Kobayashi-Miura M, Miyaji A, Akiho M, Hiyoshi M, Manako T, Nagano S, Uchio Y. Quantitative Analysis of Extracellular Matrix Changes: Glycosaminoglycans, Collagen, and Elastin in Degenerated Ligamentum Flavum in Lumbar Spinal Canal Stenosis. Shimane J. Med. Sci. 2023. 40. 1-8
Hiyoshi M, Osago H, Kobayashi-Miura M, Hara N. Detection of a glutathionyl-carbonylated group (GS-CO-) on D-dopachrome tautomerase with preferential binding of GS-CO- to MIF proteins in rat livers damaged by carbon tetrachloride. Chemico-biological interactions. 2023
Mikiko Kobayashi-Miura, Harumi Osago, Yoshifumi Hamasaki, Ikuko Takano, Mitsuki Akiho, Mineyoshi Hiyoshi, Nobumasa Hara. Decrease in Glycosaminoglycan with Aging in Normal Rat Articular Cartilage Is Greater in Females than in Males. Cartilage. 2022. 13. 3. 19476035221102566
NAKAMURA Takeshi, Hara Nobumasa, Osago Harumi, HIYOSHI Mineyoshi, KOBAYASHI-MIURA Mikiko, Tsuchiya Mikako. Effects of NAD+ Synthesis Levels on Sirtuin 1 Deacetylase Activity in Mammalian Cells. Shimane Journal of Medical Science. 2021. 38. 2. 59-66
Biochemical Basis for Decreased Serum α-1-Antichymotrypsin Level. (共著)
Medical aspects of proteases and protease inhibitors. Katunuma N et al(eds), IOS Press, Amsterdam 1997