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J-GLOBAL ID:202001001405043133   Update date: Dec. 20, 2024

Higashikuni Yasutomi

ヒガシクニ ヤストミ | Higashikuni Yasutomi
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Affiliation and department:
Job title: Assistant Professor
Other affiliations (1):
Homepage URL  (1): https://www.higashikuni-lab.org
Research field  (3): Molecular biology ,  Molecular biology ,  Cardiology
Research keywords  (18): Aging ,  Nucleic Acid Recognition ,  RNA Metabolism and Modification ,  Phenotypic screening ,  CRISPR techology ,  Cell therapy ,  Gene therapy ,  Synthetic gene circuit ,  Synthetic cardiology ,  Molecular computation and memory device ,  Cellular interaction ,  Oxidative stress ,  Organ interaction ,  Homeostatic inflammation ,  Atherosclerosis ,  Heart failure ,  Synthetic Biology ,  Cardiovascular Medicine
Research theme for competitive and other funds  (9):
  • 2023 - 2026 Elucidating pathogenic mechanisms of heart failure through RNA metabolism and protein-protein interaction mediated by transcriptional modulator IkBz
  • 2021 - 2025 Clarification of the mechanism of severe heart failure via cardiac dopamine receptor
  • 2020 - 2023 Developing novel heart failure therapy targeting DEAD-box RNA helicase
  • 2019 - 2021 Development of Next-Generation Gene Therapy for Heart Failure Through Synthetic Biology Approach
  • 2015 - 2018 Roll of innate immune system in vasculitis of Kawasaki disease
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Papers (65):
  • Wenhao Liu, Yasutomi Higashikuni, Masataka Sata. Chronobiological rhythms and artificial light at night in vascular physiology and pathology. Hypertension research : official journal of the Japanese Society of Hypertension. 2024
  • Wenhao Liu, Yasutomi Higashikuni. Self-DNA sensing in cigarette smoke-induced vascular inflammation: the role of mitochondrial DNA release in vascular endothelial cells. Hypertension research : official journal of the Japanese Society of Hypertension. 2024. 47. 3. 799-802
  • Yasutomi Higashikuni, Wenhao Liu, Masataka Sata. Nocturnal blood pressure and left ventricular hypertrophy in patients with diabetes mellitus. Hypertension research : official journal of the Japanese Society of Hypertension. 2024. 47. 3. 819-822
  • Shinnosuke Sawano, Mizuki Miura, Yasutomi Higashikuni, Hiroyuki Saigusa, Satoshi Kodera, Norifumi Takeda, Masaru Hatano, Jiro Ando, Minoru Ono, Issei Komuro. Clinical valve thrombosis and arterial embolism in a cancer patient after transcatheter aortic valve replacement. Oxford medical case reports. 2023. 2023. 11. omad125
  • Yasutomi Higashikuni, Wenhao Liu, Masataka Sata. Not a small frog in a big pond: targeting bradykinin receptor B2 signaling in vascular smooth muscle cells for treatment of hypertension. Hypertension research : official journal of the Japanese Society of Hypertension. 2023. 46. 10. 2415-2418
more...
MISC (103):
  • Wenhao Liu, Yasutomi Higashikuni, Yoichiro Hirata, Masataka Sata. Rbm15b is an RNA-Binding Protein that Protects against Adverse Cardiac Remodeling during Pressure Overload. The 88th Annual Scientific Meeting of the Japanese Circulation Society. 2024. 88回. PJ054-2
  • Wenhao Liu, Yasutomi Higashikuni, Yoichiro Hirata, Masataka Sata. The DEAD-box RNA Helicase Ddx41 Contributes to Adverse Cardiac Remodeling Induced by Pressure Overload through Modulation of RNA Metabolism. 日本循環器学会学術集会抄録集. 2024. 88回. PJ054-3
  • 東邦康智. 病的線維化の退縮を可能にする人工細胞治療の開発. ライフサイエンス振興財団助成成果報告書. 2024. 2023
  • 片岡翔平, 片岡翔平, 小林義典, 笹野哲郎, 丹野郁, 深水誠二, 村田広茂, 上野亮, 東邦康智, 稲垣大, et al. In-hospital Prognosis in Patients Requiring Venoarterial Extracorporeal Membrane Oxygenation for Refractory Ventricular Arrhythmias: a Report from the Tokyo Cardiovascular Care Unit Network Multi-center Registry. ICUとCCU. 2023. 47. 別冊. S84-S85
  • 稲垣 大, 深水 誠二, 小林 義典, 村田 広茂, 東邦 康智, 片岡 翔平, 古屋 貴宏, 池ノ内 孝, 上野 亮, 丹野 郁, et al. 心室頻拍患者の予後予測因子に関する検討 東京都CCUネットワークレジストリより. ICUとCCU. 2023. 47. 別冊. S37-S40
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Books (4):
  • 循環器内科ポケットバイブル
    中山書店 2015
  • 循環器内科臨床マニュアル
    南江堂 2013
  • 循環器内科臨床マニュアル
    南江堂 2013
  • 今日の治療と看護
    南江堂 2013
Lectures and oral presentations  (10):
  • Neural Control of Cardiac Inflammation and Remodeling
    (Basic Cardiovascular Sciences Scientific Sessions 2024 (American Heart Association) 2024)
  • 心不全と炎症変容機構
    (第136回日本循環器学会近畿地方会 2023)
  • スポーツ活動と心血管系のメンズヘルス
    (第23回日本メンズヘルス医学会 2023)
  • Homeostatic Inflammation in Heart Disease
    (2022)
  • Next-Generation Therapeutic Platforms in Cardiovascular Medicine
    (The 67th Annual Meeting of Japanese Society of Anesthesiologists 2020)
more...
Education (4):
  • 2006 - 2010 The University of Tokyo Graduate School of Medicine Internal Medicine
  • 1998 - 2002 The University of Tokyo Faculty of Medicine School of Medicine
  • 1996 - 1998 The University of Tokyo College of Arts and Sciences
  • 1993 - 1996 Komaba High School, Tsukuba University
Work history (8):
  • 2024/06 - 現在 Jichi Medical University Center for Molecular Medicine Assistant Professor
  • 2024/06 - 現在 The University of Tokyo Faculty of Medicine University Hospital Visiting Researcher
  • 2019/04 - 2024/05 The University of Tokyo Faculty of Medicine University Hospital Assistant Professor
  • 2015/10 - 2019/03 Massachusetts Institute of Technology Department of Biological Engineering Visiting Scholar
  • 2010/12 - 2015/09 The University of Tokyo Faculty of Medicine University Hospital Assistant Professor
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Committee career (4):
  • 2024/09 - 現在 自治医科大学地域医療研究支援チームCRST 支援メンバー
  • 2024/04 - 現在 The Society of Cardiovascular Endocrinology and Metabolism Councilor
  • 2024/01 - 現在 European Society of Cardiology Fellow of the European Society of Cardiology
  • 2020/04 - 現在 International Society for Heart Research Councilor
Awards (11):
  • 2018/04 - The Society of Cardiovascular Endocrinology and Metabolism Jokichi Takamine Young Investigator Award
  • 2014/07 - The Japanese Society of Inflammation and Regeneration Outstanding Presentation Award
  • 2014/04 - The Japanese Society of Molecular Medicine Young Investigator Award
  • 2014/03 - Japanese Circulation Society Young Investigator Award
  • 2012/11 - The Society of Cardiovascular Endocrinology and Metabolism Young Investigator Award
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Association Membership(s) (15):
European Society of Cardiology ,  American Heart Association ,  脳心血管抗加齢研究会 ,  日本抗加齢学会 ,  The Japanese Vascular Biology and Medicine Organization ,  The Japanese Society of Inflammation and Regeneration ,  The Japanese Society of Molecular Medicine ,  The Japanese Society of Hypertension ,  The Japanese Society of Internal Medicine ,  The Japanese Heart Failure Society ,  The Society of Cardiovascular Endocrinology and Metabolism ,  The International Society for Heart Research ,  The Japanese Association of Cardiovascular Intervention and Therapeutics ,  The Japanese College of Cardiology ,  Japan Circulation Society
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