Higashikuni Yasutomi

ヒガシクニヤストミ | Higashikuni Yasutomi

Affiliation and department：
Job title：助教
Homepage URL (1)： https://www.higashikuni-lab.org

Research field (3)： Molecular biology , Molecular biology , Cardiology

Research keywords (16)： RNA Metabolism and Modification , Phenotypic screening , CRISPR techology , Cell therapy , Gene therapy , Synthetic gene circuit , Synthetic cardiology , Molecular computation and memory device , Cellular interaction , Oxidative stress , Organ interaction , Homeostatic inflammation , Atherosclerosis , Heart failure , Synthetic Biology , Cardiovascular Medicine

Research theme for competitive and other funds (8)：

2021 - 2025 Clarification of the mechanism of severe heart failure via cardiac dopamine receptor
2020 - 2023 Developing novel heart failure therapy targeting DEAD-box RNA helicase
2019 - 2021 Development of Next-Generation Gene Therapy for Heart Failure Through Synthetic Biology Approach
2015 - 2018 Roll of innate immune system in vasculitis of Kawasaki disease
2015 - 2016 心臓における自然炎症制御機構の解明とその心リモデリングにおける役割の検討

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Papers (82)：

Yasutomi Higashikuni, Wenhao Liu, Masataka Sata. Nocturnal blood pressure and left ventricular hypertrophy in patients with diabetes mellitus. Hypertension research : official journal of the Japanese Society of Hypertension. 2023
Shinnosuke Sawano, Mizuki Miura, Yasutomi Higashikuni, Hiroyuki Saigusa, Satoshi Kodera, Norifumi Takeda, Masaru Hatano, Jiro Ando, Minoru Ono, Issei Komuro. Clinical valve thrombosis and arterial embolism in a cancer patient after transcatheter aortic valve replacement. Oxford medical case reports. 2023. 2023. 11. omad125
Yasutomi Higashikuni, Wenhao Liu, Masataka Sata. Not a small frog in a big pond: targeting bradykinin receptor B2 signaling in vascular smooth muscle cells for treatment of hypertension. Hypertension research : official journal of the Japanese Society of Hypertension. 2023. 46. 10. 2415-2418
Susumu Katsushika, Satoshi Kodera, Shinnosuke Sawano, Hiroki Shinohara, Naoto Setoguchi, Kengo Tanabe, Yasutomi Higashikuni, Norifumi Takeda, Katsuhito Fujiu, Masao Daimon, et al. An explainable artificial intelligence-enabled electrocardiogram analysis model for the classification of reduced left ventricular function. European heart journal. Digital health. 2023. 4. 3. 254-264
中村峻, 沼田玄理, 山口敏弘, 常盤洋之, 東邦康智, 野村征太郎, 笹野哲郎, 瀧本英樹, 小室一成. ER Stress-Activated Nf-κ B Signaling Pathway Induces the Upregulation of Cardiomyocyte Dopamine D1 Receptor in Heart Failure(タイトル和訳中). 日本循環器学会学術集会抄録集. 2023. 87回. OJ22-8

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MISC (23)：

Yasutomi Higashikuni. Next-Generation Therapeutic Platforms in Cardiovascular Medicine. Masui. 2020. 69. S146-S155
六車隆太郎, 福田大受, 西本幸子, 東邦康智, 田中君枝, 平田陽一郎, 八木秀介, 添木武, 島袋充夫, 佐田政隆. TLR9の活性化は虚血肢における炎症を増強し血流改善を遅延させる. 血管. 2016. 39. 1. 40-40
原知也, 福田大受, 田中君枝, 東邦康智, 平田陽一郎, 八木秀介, 添木武, 島袋充生, 佐田政隆. プロテアーゼ活性化受容体2によるマクロファージ活性化を介した新しい動脈硬化進展機序の検討. 血管. 2016. 39. 1. 45-45
Salim Hotimah Masdan, 福田大受, 東邦康智, 田中君枝, 平田陽一郎, 八木秀介, 添木武, 島袋充生, 佐田政隆. アポリポタンパク質-E欠損マウスにおいてジペプチジルペプチダーゼ-4の阻害薬であるlinagliptinはGLP-1依存的および非依存的様式で内皮機能障害と動脈硬化の形成を軽減する(Dipeptidyl peptidase-4 inhibitor, linagliptin, ameliorates endothelial dysfunction and atherogenesis in apolipoprotein-E deficient mice through GLP-1 dependent and. 血管. 2016. 39. 1. 47-47
高島啓, 福田大受, 田中君枝, 東邦康智, 平田陽一郎, 山田博胤, 添木武, 若槻哲三, 島袋充生, 佐田政隆. ω3系不飽和脂肪酸の脂質ラフト構造変化を介した抗動脈硬化作用の解明. 血管. 2016. 39. 1. 48-48

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Lectures and oral presentations (7)：

Homeostatic Inflammation in Heart Disease
(2022)
Next-Generation Therapeutic Platforms in Cardiovascular Medicine
(The 67th Annual Meeting of Japanese Society of Anesthesiologists 2020)
System Dynamics and Its Regulation in Heart Disease
(The 22th Annual Meeting of the Socienty of Cardiovascular Endocrinology and Metabolism 2018)
The Role of the Central Nervous System in Heart Disease
(The 79th Annual Scientific Meeting of the Japanese Circulation Society 2015)
The Role and the Regulatory Mechanisms of Homeostatic Inflammation in Heart Diseas
(The 3rd Homeostatic Inflammation International Symposium 2015)

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Education (4)：

2006 - 2010 The University of Tokyo Graduate School of Medicine Internal Medicine
1998 - 2002 The University of Tokyo Faculty of Medicine School of Medicine
1996 - 1998 The University of Tokyo College of Arts and Sciences
1993 - 1996 Komaba High School, Tsukuba University

Work history (6)：

2019/04 - 現在 The University of Tokyo Faculty of Medicine University Hospital Assistant Professor
2015/10 - 2019/03 Massachusetts Institute of Technology Department of Biological Engineering Visiting Scholar
2010/12 - 2015/09 The University of Tokyo Faculty of Medicine University Hospital Assistant Professor
2010/04 - 2010/12 The University of Tokyo Faculty of Medicine University Hospital Clinical Fellow
2003/06 - 2006/05 Mitsui Memorial Hospital Resident

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Awards (11)：

2018/04 - The Society of Cardiovascular Endocrinology and Metabolism Jokichi Takamine Young Investigator Award
2014/07 - The Japanese Society of Inflammation and Regeneration Outstanding Presentation Award
2014/04 - The Japanese Society of Molecular Medicine Young Investigator Award
2014/03 - Japanese Circulation Society Young Investigator Award
2012/11 - The Society of Cardiovascular Endocrinology and Metabolism Young Investigator Award

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Association Membership(s) (12)：

American Heart Association , The Japanese Vascular Biology and Medicine Organization , The Japanese Society of Inflammation and Regeneration , The Japanese Society of Molecular Medicine , The Japanese Society of Hypertension , The Japanese Society of Internal Medicine , The Japanese Heart Failure Society , The Society of Cardiovascular Endocrinology and Metabolism , The International Society for Heart Research , The Japanese Association of Cardiovascular Intervention and Therapeutics , The Japanese College of Cardiology , Japan Circulation Society

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