Kuge Shusuke

Kuge Shusuke | Kuge Shusuke

Homepage URL (1)： https://www.tohoku-mpu.ac.jp/laboratory/bisei/index.html

Research field (3)： Virology , Molecular biology , Pharmaceuticals - health and biochemistry

Research theme for competitive and other funds (18)：

2022 - 2025 ヒトコロナウイルス感染を阻害するantiviral-oligo RNAの創出
2018 - 2022 Is ROS-sensing BAG-1/ATF4-system a regulatory system for ferroptosis?
2009 - 2011 Study on sensing of oxidative stress and redox cell signaling
2007 - 2011 Cellular Systems Involved in Development and Regulation of Toxicity of Methylmercury
2008 - 2009 小胞体表面の異常タンパク質の感知とERAD-CおよびUPRの誘導機構の解析

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Papers (45)：

Atsushi Inose-Maruyama, Hayato Irokawa, Kouki Takeda, Keiko Taguchi, Masanobu Morita, Masayuki Yamamoto, Masato Sasaki, Shusuke Kuge. Bag1 protein loss sensitizes mouse embryonic fibroblasts to glutathione depletion. Cell stress & chaperones. 2024. 29. 3. 497-509
Masato Sasaki, Kazuo Yamamoto, Takeshi Ueda, Hayato Irokawa, Kouki Takeda, Ryoya Sekine, Fumie Itoh, Yutaka Tanaka, Shusuke Kuge, Nobuyuki Shibata. One-carbon metabolizing enzyme ALDH1L1 influences mitochondrial metabolism through 5-aminoimidazole-4-carboxamide ribonucleotide accumulation and serine depletion, contributing to tumor suppression. Scientific Reports. 2023. 13. 1
Ryoya Sekine, Satsuki Tsuno, Hayato Irokawa, Kazuhiro Sumitomo, Tianxue Han, Yusuke Sato, Seiichi Nishizawa, Kouki Takeda, Shusuke Kuge. Inhibition of SARS-CoV-2 nucleocapsid protein-RNA interaction by guanosine oligomeric RNA. JOURNAL OF BIOCHEMISTRY. 2023
Hayato Irokawa, Satoshi Numasaki, Shin Kato, Kenta Iwai, Atsushi Inose-Maruyama, Takumi Ohdate, Gi-Wook Hwang, Takashi Toyama, Toshihiko Watanabe, Shusuke Kuge. Comprehensive analyses of the cysteine thiol oxidation of PKM2 reveal the effects of multiple oxidation on cellular oxidative stress response. The Biochemical journal. 2021. 478. 7. 1453-1470
Teruo Kuroda, Atsushi Matsuzawa, Shusuke Kuge. [Current Status of and Countermeasures against Infectious Diseases]. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan. 2020. 140. 7. 885-885

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MISC (39)：

久下周佐. 抗ウイルスG quadruplex RNAオリゴマーの創出. 日本薬学会144年会. 2024. 29-413-pm
武田洸樹, 秋葉理名, 色川隼人, 久下周佐. ヒト非小細胞性肺癌H1299細胞におけるBAG-1によるヘムオキシゲナーゼ-1(HO-1)の発現制御メカニズムの解析. 日本薬学会144年会. 2024. 29P-9m254
色川隼人, 猪瀬敦史, 武田洸樹, 木村朋寛, 中島修, 佐々木雅人, 関根僚也, 久下周佐. 酸化ストレスセンサーBAG1の欠損が心機能に与える影響の解析. 日本薬学会144年会. 2024. 29P-9m262
久下周佐, 関根僚也, 末永司, 津野沙月, 色川隼人, 生田和史, 神田輝, 住友和弘, 西村秀一, 武田洸樹. ヒトコロナウイルスおよびインフルエンザAウイルスに抗ウイルス作用を示す新規オリゴヌクレオチドの創出. 第70回日本ウイルス学会学術集会. 2023. WS4-3
関根僚也, 津野沙月, 色川隼人, 末永司, 住友和弘, Tianxue Ha, 佐藤雄介, 西澤精一, 武田洸樹, 久下周佐. β-コロナウイルスのRNP形成に作用する化合物の探索と効果の検証. 日本薬学会134年会. 2023. 26P2-am1-026S

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Work history (1)：

2010/04 - 現在 Tohoku Medical and Pharmaceutical University Faculty of Pharmaceutical Sciences, Department of Microbiology Professor

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