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J-GLOBAL ID：202001004269502594 Update date: Aug. 22, 2024

OSONOI SHO

オソノイショウ | OSONOI SHO

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Affiliation and department：

Research field (1)： Metabolism and endocrinology

Research keywords (3)： Islets of Langerhans , Diabetic neuropathy , Diabetes

Research theme for competitive and other funds (1)：

2018 - 2021 Development of novel treatment approach for diabetic polyneuropathy targeting RAGE signaling and macrophage polarization

Papers (67)：

Masaki Ryuzaki, Hiroki Mizukami, Yuki Takeuchi, Sho Osonoi, Takanori Sasaki, Zhenchao Wang, Hanae Kushibiki, Takahiro Yamada, Keisuke Yamazaki, Saori Ogasawara, et al. Moderate cryptoxanthin intake correlates with maintenance of a proper PINT index in a general Japanese population. Nutritional neuroscience. 2024. 1-11
Hanae Kushibiki, Hiroki Mizukami, Sho Osonoi, Yuki Takeuchi, Takanori Sasaki, Saori Ogasawara, Kanichiro Wada, Shin Midorikawa, Masaki Ryuzaki, Zhenchao Wang, et al. Tryptophan metabolism and small fibre neuropathy: a correlation study. Brain communications. 2024. 6. 2. fcae103
Sho Osonoi, Hiroki Mizukami, Yuki Takeuchi, Hikari Sugawa, Saori Ogasawara, Shizuka Takaku, Takanori Sasaki, Kazuhiro Kudoh, Koichi Ito, Kazunori Sango, et al. RAGE activation in macrophages and development of experimental diabetic polyneuropathy. JCI Insight. 2022. 7. 23
Yuki Takeuchi, Hiroki Mizukami, Kazuhiro Kudoh, Sho Osonoi, Takanori Sasaki, Hanae Kushibiki, Saori Ogasawara, Yutaro Hara, Akiko Igawa, Xuekai Pan, et al. The diversity and abundance of gut microbiota are associated with the pain sensation threshold in the Japanese population. Neurobiology of disease. 2022. 173. 105839-105839
Luka Suzuki, Takeshi Miyatsuka, Miwa Himuro, Yuka Wakabayashi, Sho Osonoi, Masaki Miura, Takehiro Katahira, Yoshio Fujitani, Hitoshi Iida, Hiroki Mizukami, et al. Cumulative autophagy insufficiency in mice leads to progression of β-cell failure. Biochemical and biophysical research communications. 2022. 611. 38-45

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MISC (30)：

Kazuhiro Kudoh, Yuki Takeuchi, Sho Osonoi, Takanori Sasaki, Saori Ogasawara, Soroku Yagihashi, Hiroki Mizukami. Changes in Oral and Intestinal Bacterial Flora Associated with Pain Thresholds. DIABETES. 2022. 71
Sho Osonoi, Hiroki Mizukami, Saori Ogasawara, Kazuhiro Kudoh, Makoto Daimon, Soroku Yagihashi. Proinflammatory Macrophage Impairs Retrograde Axonal Transport via Inflammation and Insulin Resistance in Sensory Neurons. DIABETES. 2022. 71
Yuki Takeuchi, Hiroki Mizukami, Sho Osonoi, Kazuhiro Kudoh, Takanori Sasaki, Soroku Yagihashi. Partial Pancreatectomy Increased alpha-Cell Volume Density, but Not Compensated beta-Cell Volume in Japanese Subjects. DIABETES. 2022. 71
高橋雅也, 宮塚健, 鈴木路可, 遲野井祥, 氷室美和, 三浦正樹, 片平雄大, 若林侑香, 福中彩子, 西田友哉, et al. 妊娠糖尿病と糖尿病合併妊娠の診療Update 周産期膵β細胞におけるセロトニン産生の動的変化. 糖尿病. 2022. 65. Suppl.1. S-46
Sho Osonoi, Hiroki Mizukami, Kazuhiro Kudo, Yasuhiko Yamamoto. RAGE-Dependent Macrophage Activation Aggravates Retrograde Axonal Transport via Attenuated Insulin Signaling of Peripheral Nerves in Experimental Diabetic Polyneuropathy. DIABETES. 2021. 70

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Education (2)：

2016 - 2022 Hirosaki University Graduate School of Medicine
2008 - 2014 Hirosaki University School of Medicine

Work history (5)：

2022/09 - 現在 Cincinnati Children's Hospital Medical Center
2022/01 - 2022/08 Hirosaki University Hospital Department of Endocrinology and Diabetes Assistant professor
2021/04 - 2021/12 むつ総合病院糖尿病内分泌内科副部長
2020/04 - 2021/03 Hirosaki University Graduate School of Medicine Endocrinology and Metabolism Research Associate
2019/04 - 2020/03 Hirosaki University Graduate School of Medicine Pathology and Molecular Medicine Research Associate

Awards (5)：

2022/05 - Japan Society of Experimental Diabetes and Obesity Young Investigator Award
2022/05 - The Japanese Diabetes Society Young Investigator Award
2021/10 - Japan Society of Diabetic Complication Excellent Presentation Award
2019/11 - Hirosaki Medical Science Forum Best presentation award
2019/08 - The Japanese Study Group of Diabetic Neuropathy Best presentation award

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