Job title:
准教授
Research theme for competitive and other funds (6):
2021 - 2024 RNAスプライシングによる病気発症メカニズムの解明
2018 - 2021 Elucidation of the intron recognition mechanism by U2AF1
2011 - 2013 U2AF複合体によるイントロン認識機構の構造生物学的研究
2011 - 2013 structural studies of the mechanism of eukaryotic translation initiation
2009 - 2010 Structural studies on influenza viral RNA polymerase for designing new anti-viral drug
2000 - 2001 一酸化窒素センサー蛋白質グアニル酸シクラーゼの分子内情報伝達機構の解明
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Papers (26):
Yuki Uchida, Yuko Nariai, Eiji Obayashi, Yoshitsugu Tajima, Tomohiro Koga, Atsushi Kawakami, Takeshi Urano, Hiroki Kamino. Generation of antagonistic monoclonal antibodies against the neoepitope of active mouse interleukin (IL)-18 cleaved by inflammatory caspases. Archives of biochemistry and biophysics. 2022. 727. 109322-109322
Naomi Nakayama, Gyosuke Sakashita, Takashi Nagata, Naohiro Kobayashi, Hisashi Yoshida, Sam-Yong Park, Yuko Nariai, Hiroaki Kato, Eiji Obayashi, Kentaro Nakayama, et al. Nucleus Accumbens-Associated Protein 1 Binds DNA Directly through the BEN Domain in a Sequence-Specific Manner. Biomedicines. 2020. 8. 12. 608-608
Hisashi Yoshida, Sam-Yong Park, Gyosuke Sakashita, Yuko Nariai, Kanako Kuwasako, Yutaka Muto, Takeshi Urano, Eiji Obayashi. Elucidation of the aberrant 3' splice site selection by cancer-associated mutations on the U2AF1. Nature communications. 2020. 11. 1. 4744-4744
Yuko Nariai, Hiroki Kamino, Eiji Obayashi, Hiroaki Kato, Gyosuke Sakashita, Tomoko Sugiura, Kiyoshi Migita, Tomohiro Koga, Atsushi Kawakami, Kazuma Sakamoto, et al. Generation and characterization of antagonistic anti-human interleukin (IL)-18 monoclonal antibodies with high affinity: Two types of monoclonal antibodies against full-length IL-18 and the neoepitope of inflammatory caspase-cleaved active IL-18. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS. 2019. 663. 71-82
DS Lee, SY Park, K Yamane, E Obayashi, H Hori, Y Shiro. Structural characterization of n-butyl-isocyanide complexes of cytochromes P450nor and P450cam. BIOCHEMISTRY. 2001. 40. 9. 2669-2677
E Obayashi, H Shimizu, SY Park, H Shoun, Y Shiro. Mutation effects of a conserved threonine (Thr243) of cytochrome P450nor on its structure and function. JOURNAL OF INORGANIC BIOCHEMISTRY. 2000. 82. 1-4. 103-111