Miki Yasuo

ミキヤスオ | Miki Yasuo

Affiliation and department：
Job title： Assistant professor

Research field (2)： Neurology , Neuropathology

Research keywords (5)： Neurodegenerative diseases , Neuropathology , Parkinson's disease , Dementia with Lewy bodies , Multiple system atrophy

Research theme for competitive and other funds (12)：

2022 - 2026 オリゴマーを標的とするシヌクレイノパチーの新規治療法開発
2022 - 2025 GABA-A受容体パルミトイル化によるベンゾジアゼピン系薬剤耐性メカニズムの解明
2022 - 2024 Developing new strategies for an early diagnosis of neurodegenerative diseases and their therapy
2021 - 2024 Understanding the mechanism of memory impairment in Multiple system atrophy to establish its therapeutic strategy
2018 - 2022 Understanding molecular mechanisms of synucleinopathies and prodromal treatment by activating autophagy

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Papers (121)：

Yuri Kobori, Mayuki Tachizaki, Tadaatsu Imaizumi, Yusuke Tanaka, Kazuhiko Seya, Yasuo Miki, Shogo Kawaguchi, Tomoh Matsumiya, Yuki Tobisawa, Chikara Ohyama, et al. TMEM2 suppresses TLR3-mediated IFN-β/ISG56/CXCL10 expression in BEAS-2B bronchial epithelial cells. Molecular biology reports. 2024. 51. 1. 417-417
Yusaku Chukai, Ginga Ito, Yasuo Miki, Koichi Wakabayashi, Ken Itoh, Eriko Sugano, Hiroshi Tomita, Tomokazu Fukuda, Taku Ozaki. Role of calpain-5 in cerebral ischemia and reperfusion injury. Biochimica et biophysica acta. General subjects. 2024. 1868. 1. 130506-130506
Melek Firat Altay, Senthil T Kumar, Johannes Burtscher, Somanath Jagannath, Catherine Strand, Yasuo Miki, Laura Parkkinen, Janice L Holton, Hilal A Lashuel. Development and validation of an expanded antibody toolset that captures alpha-synuclein pathological diversity in Lewy body diseases. NPJ Parkinson's disease. 2023. 9. 1. 161-161
Fumiaki Mori, Hina Yasui, Yasuo Miki, Tomoya Kon, Akira Arai, Hidekachi Kurotaki, Masahiko Tomiyama, Koichi Wakabayashi. Colocalization of TDP-43 and stress granules at the early stage of TDP-43 aggregation in amyotrophic lateral sclerosis. Brain pathology (Zurich, Switzerland). 2023. e13215
Shun Ishiyama, Takafumi Hasegawa, Naoto Sugeno, Junpei Kobayashi, Shun Yoshida, Yasuo Miki, Koichi Wakabayashi, Mitsunori Fukuda, Yasushi Kawata, Takaaki Nakamura, et al. Sortilin acts as an endocytic receptor for α-synuclein fibril. FASEB journal. 2023. 37. 7. e23017

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MISC (119)：

三木康生, 下山修司, 早狩亮, 今智矢, 上野達哉, 丹治邦和, 松宮朋穂, 対馬栄輝, 森文秋, 冨山誠彦, et al. パーキンソン病患者の末梢血単核球におけるオートファジーの変化. 弘前医学. 2019. 69. 1-4. 201-201
隅寿恵, 三木康生, 陸雄一, 加藤信介, 若林孝一, 吉田眞理, 望月秀樹. PLA2G6関連神経変性症のαシヌクレイノパチーにおけるtyrosine hydroxylaseの関与. 臨床神経学. 2018. 58. Suppl. S239-S239
Kon T. PD. Aomori Kenritsu Tyuuoubyouin Ishi. 2018. 63. 2. 74-75
若林孝一, 三木康生. 【非アルツハイマー型認知症の病理学】レヴィ小体型認知症の全身病理. BRAIN and NERVE: 神経研究の進歩. 2018. 70. 5. 0489-0500
古川智範, 二階堂義和, 下山修司, 三木康生, 古賀浩平, 中村和彦, 若林孝一, 上野伸哉. ジアゼパム長期投与マウスにおける脳内Lcn2発現および認知機能の解析. 弘前医学. 2017. 68. 1. 88-88

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Books (2)：

Autophagy Dysfunction In Alzheimer's Disease and Dementia
Elsevier 2022 ISBN:9780323899062
図説神経機能解剖テキスト
文光堂 2017 ISBN:9784830615467

Lectures and oral presentations (4)：

Pathological substrate of memory impairment in multiple system atrophy
(2022)
The implication of autophagy in Alzheimer's disease and dementia
(61th Annual Meeting of the Japanese Society of Neurology)
シヌクレイノパチーにおけるオートファジーの異常とその活性化による治療の可能性
(第36回日本認知症学会学術集会 2017)
シヌクレイノパチー
(第58回日本神経病理学会総会学術研究会 2017)

Education (2)：

Professional career (2)：

Work history (5)：

2013/04 - 現在 Hirosaki University Graduate School of Medicine Department of Neuropathology Assistant Professor
2018/04 - 2020/03 University College London Queen Square Brain Bank for Neurological Disorders Honorary research associate
2007/10 - 2013/04 Aomori Prefectural Central Hospital Department of Neurology Clinical fellow
2007/04 - 2007/09 Hirosaki University Hospital Department of Neurology Clinical fellow
2005/04 - 2007/03 Yodogawa Christian Hospital Registrar

Committee career (5)：

2020/10 - 現在 The Japanese Society of Neuropathology Committee for Neuropathology Education
2020/06 - 現在 The Japanese Society of Neuropathology Brain Bank committee
2019/09 - 現在 Movement Disorder Society Member of Movement Disorder Society MSA criteria revision task force
2016/06 - 現在 The Japanese Society of Neuropathology Councilor
2016/06 - 2018/03 The Japanese Society of Neuropathology Brain Bank Committee

Awards (8)：

2024/05 - 日本神経病理学会第65回日本神経病理学会総会学術研究会優秀演題賞
2023/12 - Hirosaki University The Endo Award Clinicopathological variability of multiple system atrophy
2020/07 - The Sakurai Memorial Fund for Medical Research
2019/07 - The Japanese Society of Neuropathology JSNP award
2018/03 - The Uehara Memorial Foundation Research Fellowship

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Association Membership(s) (4)：

The Japan Stroke Society , The Japanese Society of Neuropathology , Japanese Society of Neurology , The Japansese Society of Internal Medicine

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