Research keywords (6)：
macrophage
, Inflammation
, Bone
, Fibrinolysis
, vascular dysfunction
, Fibrosis
Research theme for competitive and other funds (6)：
2017 - Alpha2-antiplasmin をターゲットとした強皮症治療法の開発
2013 - 2016 The roles of uPA/uPAR on the inflammatory osteoclastogenesis
2014 - α2APをターゲットとした強皮症治療法の開発
2014 - Alpha2-antiplasmin をターゲットとした強皮症治療法の開発
2011 - 2012 The role of uPAR in the inflammation-induced bone resorption
2009 - 2010 The role of uPAR on the LPS-induced bone resorption.
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Papers (58)：
Yosuke Kanno, Kinomi Toyama, Haruna Shibata, Osamu Matsuo, Kei-Ichi Ozaki. α2-antiplasmin is associated with macrophage activation and fibrin in a macrophage activation syndrome mouse model. Clinical and experimental immunology. 2024
Yosuke Kanno. The uPA/uPAR System Orchestrates the Inflammatory Response, Vascular Homeostasis, and Immune System in Fibrosis Progression. International journal of molecular sciences. 2023. 24. 2
Y Kanno, E Shu. α2-Antiplasmin as a Potential Therapeutic Target for Systemic Sclerosis. Life. 2022. 12. 3. 396
Yosuke Kanno, Kaho Tsuchida, Chihiro Maruyama, Kyoko Hori, Hanako Teramura, Shiho Asahi, Osamu Matsuo, Kei-Ichi Ozaki. Alpha2-antiplasmin deficiency affects depression and anxiety-like behavior and apoptosis induced by stress in mice. Journal of basic and clinical physiology and pharmacology. 2021
Yosuke Kanno, Akira Ishisaki, Eri Kawashita, Naoyuki Chosa, Keiichi Nakajima, Tatsuji Nishihara, Kuniaki Toyoshima, Kiyotaka Okada, Shigeru Ueshima, Kenji Matsushita, et al. Plasminogen/plasmin modulates bone metabolism by regulating the osteoblast and osteoclast function (vol 286, pg 8952, 2011). JOURNAL OF BIOLOGICAL CHEMISTRY. 2014. 289. 22. 15154-15154
Y. Kanno, E. Kawashita, A. Kokado, K. Okada, S. Ueshima, H. Kaji, O. Matsuo, H. Matsuno. Alpha2-antiplasmin regulates the development of fibrosis by Pgf2 alpha synthesis through Atgl/Ipla2. JOURNAL OF THROMBOSIS AND HAEMOSTASIS. 2013. 11. 34-34
Y. Kanno, A. Kokado, E. Kawashita, M. Tani, K. Okada, S. Ueshima, O. Matsuo, H. Matsuno. The role of a2AP in the development of renal interstitial fibrosis. JOURNAL OF THROMBOSIS AND HAEMOSTASIS. 2013. 11. 438-438
E. Kawashita, Y. Kanno, H. Asayama, K. Okada, S. Ueshima, H. Kaji, O. Matsuo, H. Matsuno. Alpha2-antiplasmin regulates dendritic growth and synapse formation. JOURNAL OF NEUROCHEMISTRY. 2012. 123. 55-56
