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J-GLOBAL ID：202001014650062881 Update date: Jan. 15, 2025

BO Tomoki

ボウトモキ | BO Tomoki

Affiliation and department：
Job title：助教

Research field (5)： Other , Veterinary medicine , Radiology , Tumor biology , Environmental effects of radiation

Research keywords (4)： tumor metabolism , Radiation Oncology , Raditaion Biology , mitochondria

Research theme for competitive and other funds (5)：

2024 - 2027 がん窒素代謝を標的とした新規放射線療法開発のための基盤研究
2021 - 2024 放射線による中性アミノ酸代謝動態の解析とこれを標的とした新規がん治療法の開発
2023 - 放射線照射時のアンモニア代謝動態の解析とそれを標的とした新規がん放射線療法の開発に向けた基礎的研究
2020 - 2022 LAT1 inhibitor JPH203 sensitizes cancer cells to radiation by enhancing radiation-induced cellular senescence
2019 - 2021 放射線によるミトコンドリア形態機能応答とそれらを標的とした新規がん治療法開発

Papers (20)：

Tomoki Bo, Tsukasa Osaki, Junichi Fujii. Dephosphorylation of branched-chain α-keto acid dehydrogenase E1α (BCKDHA) promotes branched-chain amino acid catabolism and renders cancer cells resistant to X-rays by mitigating DNA damage. Biochemical and biophysical research communications. 2025. 742. 151154-151154
Tomoki Bo, Junichi Fujii. Primary Roles of Branched Chain Amino Acids (BCAAs) and Their Metabolism in Physiology and Metabolic Disorders. Molecules (Basel, Switzerland). 2024. 30. 1
Tomoki Bo, Naoki Fukuda, Junko Ozaki, Ayumi Inoue, Kiyoaki Katahira, Tunekata Ito. Double-decker cage reduces mount frequency and ejaculation latency, resulting in reduced weight loss in male rats after mating behavior. Experimental animals. 2024
Koya Yamashita, Hironobu Yasui, Tomoki Bo, Masaki Fujimoto, Osamu Inanami. Mechanism of the Radioresistant Colorectal Cancer Cell Line SW480RR Established after Fractionated X Irradiation. Radiation research. 2024
Tomoki Bo, Hidekazu Nohara, Ken-Ichi Yamada, Satoshi Miyata, Junichi Fujii. Ascorbic Acid Protects Bone Marrow from Oxidative Stress and Transient Elevation of Corticosterone Caused by X-ray Exposure in Akr1a-Knockout Mice. Antioxidants. 2024. 13. 2

MISC (1)：

房知輝, 房知輝, 山盛徹, 安井博宣, 稲波修. Mitochondrial dynamics after irradiation are involved in radiosensitivity. 放射線生物研究. 2020. 55. 4

Lectures and oral presentations (10)：

Education (2)：

2016 - 2020 Hokkaido University Graduate School, Division of Veterinary Medicine
2012 - 2016 Hokkaido University Faculty of Veterinary Medicine Veterinary Medicine

Work history (2)：

Committee career (6)：

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Awards (8)：

2023/09 - International Congress of Radiation Research 2023 Early Career Investigator Award in ICRR2023 Heme biosynthesis is upregulated to enhance oxidative phosphorylation for cell survival after X-irradiation.
2021/05 - 第74回日本酸化ストレス学会/第21回日本NO学会合同学術集会一般演題・ポスター優秀賞
2019/08 - European Radiation Research Society Young Investigator Award 2019 in ICRR2019
2019/03 - 加藤記念バイオサイエンス振興財団加藤記念国際交流助成
2018/11 - 日本放射線影響学会第61回大会優秀演題発表賞

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Association Membership(s) (3)：

日本酸化ストレス学会 , 日本獣医学会 , 日本放射線影響学会

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