Research field (5)：
Molecular biology
, Cell biology
, Fetal medicine/Pediatrics
, Pathobiochemistry
, Zoological sciences
Research keywords (1)：
embryonic stem cells, induced pluripotent stem cells, mesenchymal stem cells, rare genetic diseases, hypophosphatasia, translational research
Research theme for competitive and other funds (7)：
2023 - 2026 先天性遺伝子疾患に対する胎児期・新生児期細胞移植療法の開発
2020 - 2023 Phase I / IIa Physician-initiated clinical trial to investigate the safety and efficacy of high-purity mesenchymal stem cell (REC-01) transplantation in pediatric patients with severe hypophosphatase (FIH study)
2018 - 2021 Development of clinically applicable cell transplantation therapies
2017 - 2020 Development of bone regeneration technology using high-purity mesenchymal stem cells for congenital bone system diseases
2015 - 2017 Development of therapeutic technology for hypophosphatasia using genetically corrected mesenchymal stem cells
2015 - 2016 高純度間葉系幹細胞を用いた骨系統疾患の治療技術開発
2013 - 2016 患者iPS細胞を用いた低フォスファターゼ症の治療技術開発
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Papers (11)：
Lu Liu, Jiahao Yang, Yoshinori Otani, Takahiro Shiga, Akihiro Yamaguchi, Yasuaki Oda, Miho Hattori, Tsukimi Goto, Shuichi Ishibashi, Yuki Kawashima-Sonoyama, et al. MELAS-Derived Neurons Functionally Improve by Mitochondrial Transfer from Highly Purified Mesenchymal Stem Cells (REC). International Journal of Molecular Sciences. 2023. 24. 24. 17186-17186
Yang J, Liu L, Oda Y, Wada K, Ago M, Matsuda S, Hattori M, Goto T, Ishibashi S, Kawashima Y, et al. Extracellular Vesicles and Cx43-Gap Junction Channels Are the Main Routes for Mitochondrial Transfer from Ultra-Purified Mesenchymal Stem Cells, RECs. International journal of molecular sciences. 2023. 24. 12
Yang J, Liu L, Oda Y, Wada K, Ago M, Matsuda S, Hattori M, Goto T, Kawashima Y, Matsuzaki Y, et al. Highly-purified rapidly expanding clones, RECs, are superior for functional-mitochondrial transfer. Stem cell research & therapy. 2023. 14. 1
Taketani, T., Oyama, C., Oda, Y., Murphy, L. Hypophosphatasia. Human Pathobiochemistry: From Clinical Studies to Molecular Mechanisms. 2019
Takeshi Taketani, Chigusa Oyama, Aya Mihara, Yuka Tanabe, Mariko Abe, Tomohiro Hirade, Satoshi Yamamoto, Ryosuke Bo, Rie Kanai, Taku Tadenuma, et al. Ex Vivo Expanded Allogeneic Mesenchymal Stem Cells With Bone Marrow Transplantation Improved Osteogenesis in Infants With Severe Hypophosphatasia. Cell transplantation. 2015. 24. 10. 1931-43
Mesenchymal stem cell treatment for blood diseases
2020
Hypophosphatasia: From Clinical Studies to Molecular Mechanisms
Human Pathobiochemistry, Springer 2019
Generation of induced pluripotent stem cells from mesenchymal stromal cells derived from human third molars(method).
Stem Cells and Cancer Stem Cells Series, Springer 2011
Human Mesenchymal Stem Cells and iPS Cells (Preparation Methods)
Springer Protocol Handbook Series, Springer 2011
Treatment approach for hypophosphatasia with highly purified human mesenchymal stem cells “REC”
(10th International Conference on Children’s Bone Health 2022)
Highly-purified Mesenchymal stem cell(REC) is superior for mitochondria transfer
(日本小児科学会雑誌 2022)
