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J-GLOBAL ID：202001016468456940   Update date: Dec. 24, 2024

Goyama Susumu

ゴウヤマ ススム | Goyama Susumu
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Affiliation and department：
東京大学 大学院新領域創成科学研究科 メディカルゲノム専攻 先進分子腫瘍学分野

About 東京大学 大学院新領域創成科学研究科 メディカルゲノム専攻 先進分子腫瘍学分野


Job title： 教授
Research field  (1)： Hematology and oncology
Research keywords  (5)： Tumor Immunity ,  Transcription Factor ,  Epigenetics ,  Hematological Malignancies ,  Leukemia
Research theme for competitive and other funds  (15)：
  • 2022 - 2026 Identification of tumor driver lncRNAs in myeloid tumors and development of lncRNA-targeting therapies
  • 2022 - 2025 骨髄系腫瘍におけるドライバーlncRNAの同定とlncRNA標的医薬の開発
  • 2022 - 2024 膜のない構造体パラスペックルの生体内での役割と生物学的意義の解明を目指して
  • 2022 - 2024 Identification of the cell of origin of infant leukemia with pluripotency
  • 2021 - 2023 Development of proteostasis modulators targeting the co-chaperon E3 ligase STUB1
Show all
Papers (100)：
  • Wenyu Zhang, Keita Yamamoto, Yu-Hsuan Chang, Tomohiro Yabushita, Yangying Hao, Ruka Shimura, Jakushin Nakahara, Shiori Shikata, Kohei Iida, Qianyi Chen, et al. HDAC7 is a potential therapeutic target in acute erythroid leukemia. Leukemia. 2024. 38. 12. 2614-2627
  • Yuko Shimosato, Keita Yamamoto, Yuhan Jia, Wenyu Zhang, Norio Shiba, Yasuhide Hayashi, Shuichi Ito, Toshio Kitamura, Susumu Goyama. NPM1-fusion proteins promote myeloid leukemogenesis through XPO1-dependent HOX activation. Leukemia. 2024
  • Naru Sato, Susumu Goyama, Yu-Hsuan Chang, Takeshi Fujino, Tamami Denda, Shuhei Asada, Shiori Shikata, Xiaoxiao Liu, Taishi Yonezawa, Reina Takeda, et al. CH-related Mutant ASXL1 Promotes Atherosclerosis in Mice via Dysregulated Innate Immunity. 2024
  • Emi Sugimoto, Jingmei Li, Yasutaka Hayashi, Kohei Iida, Shuhei Asada, Tsuyoshi Fukushima, Moe Tamura, Shiori Shikata, Wenyu Zhang, Keita Yamamoto, et al. Hyperactive Natural Killer cells in Rag2 knockout mice inhibit the development of acute myeloid leukemia. Communications biology. 2023. 6. 1. 1294-1294
  • Muran Xiao, Shinji Kondo, Masaki Nomura, Shinichiro Kato, Koutarou Nishimura, Weijia Zang, Yifan Zhang, Tomohiro Akashi, Aaron Viny, Tsukasa Shigehiro, et al. BRD9 determines the cell fate of hematopoietic stem cells by regulating chromatin state. Nature communications. 2023. 14. 1. 8372-8372
ｍore...
MISC (24)：
  • 田中洋介, 田中洋介, 福島剛, 小出周平, 合山進, 岩間厚志, 須田年生, 北村俊雄. The hematopoietic stem cell picture based on their division patterns. 日本再生医療学会総会(Web). 2023. 22nd
  • Yasutaka Hayashi, Kimihito Cojin Kawabata, Yosuke Tanaka, Yasufumi Uehara, Shigeru Kiryu, Yasunori Ota, Yusuke Yoshioka, Yo Mabuchi, Tatsuki Sugiyama, Keiko Mikami, et al. Impaired Osteoblastic Differentiation of MSCs Suppresses Normal Hematopoiesis in MDS. BLOOD. 2020. 136
  • 米澤大志, 高橋宏隆, 澤崎達也, 北村俊雄, 合山進. DTX2はRUNX1のユビキチン化および脱アセチル化を促進し,白血病細胞の増殖を抑制する. 日本血液学会学術集会抄録(Web). 2020. 82nd
  • 藤野赳至, 越智陽太郎, 昆彩奈, 合山進, 小川誠司, 北村俊雄. Asxl1変異とStag2の欠失は協調してクロマチン構造を開き骨髄異形成症候群の発症を誘導する. 日本血液学会学術集会抄録(Web). 2020. 82nd
  • Taishi Yonezawa, Hirotaka Takahasi, Tatsuya Sawasaki, Toshio Kitamura, Susumu Goyama. The Ubiquitin Ligase DTX2 Promotes Nuclear Export of RUNX1 and Inhibits RUNX1-Dependent Leukemogenesis. BLOOD. 2019. 134
ｍore...
Education (2)：
  • 2002 - 2006 Graduate School of Medicine and Faculty of Medicine
  • 1993 - 1999 The University of Tokyo Graduate School of Medicine and Faculty of Medicine
Professional career (1)：
  • 博士(医学) (東京大学)
Work history (10)：
  • 2020/04 - 現在 Graduate School of Frontier Sciences, The University of Tokyo Division of Molecular Oncology Professor
  • 2015/03 - 2020/03 The Institute of Medical Science, The University of Tokyo Division of Cellular Therapy Associate Professor
  • 2012/04 - 2015/02 Cincinnati Children’s Hospital Medical Center Experimental Hematology and Cancer Biology Research Associate
  • 2010/04 - 2012 Cincinnati Children’s Hospital Medical Center Postdoctoral Fellow for Research Abroad
  • 2009/07 - 2010/03 Cincinnati Children’s Hospital Medical Center Division of Experimental Hematology and Cancer Biology
Show all
Association Membership(s) (2)：
Japanese Cancer Association ,  Japan Society of Hematology
※ Researcher’s information displayed in J-GLOBAL is based on the information registered in researchmap. For details, see here.

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