Job title:
助教
Research theme for competitive and other funds (9):
2019 - 2020 APサイト特異的切断およびアルキル化によるDNA修復阻害剤の開発
2017 - 2018 Development of anticancer drug based on AP site repair inhibition
2017 - 2017 APサイト修復阻害に着目した新規抗がん剤の検討
2016 - 2016 APサイト修復阻害を起こす新規結合分子の開発
2015 - 2016 Development of selective binding and cleavage ligands for the AP sites
2013 - 2014 DNAアルキル化抗癌剤の作用増強を目指した塩基欠損サイト結合分子の開発
2012 - 2013 脱塩基部位を標的とした生化学的ツールの開発
2011 - 2012 治療への応用を目指した塩基欠損部位認識分子の開発
2010 - 2011 塩基欠損部位の特性に着目した特異的認識分子の開発
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Papers (3):
Yukiko S. Abe, Shigeki Sasaki. The adduct formation between the thioguanine-polyamine ligands and DNA with the AP site under UVA irradiated and non-irradiated conditions. Bioorganic & Medicinal Chemistry. 2019
Yukiko S. Abe, Shigeki Sasaki. DNA cleavage at the AP site via b-elimination mediated by the AP site-binding ligands. Bioorganic & Medicinal Chemistry. 2016. 24. 4. 910-914
Yukiko Abe, Osamu Nakagawa, Rie Yamaguchi, Shigeki Sasaki. Synthesis and Binding Properties of New Selective Ligands for the Nucleobase Opposite the AP Site. Bioorganic & Medicinal Chemistry. 2012. 20. 11