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J-GLOBAL ID：202001020247335037 Update date: Apr. 02, 2025

Hiraishi Keizo

ヒライシケイゾウ | Hiraishi Keizo

Affiliation and department：

Research field (3)： Pharmaceuticals - chemistry and drug development , Physiology , Pharmacology

Research keywords (4)：組織の線維化・リモデリング , TRPチャネル , pulmonary hypertension , 消化管線維化

Research theme for competitive and other funds (2)：

2023 - 2026 交感神経系により進行する心臓リモデリングにおける、TRPM7チャネルの役割の解明
2021 - 2024 New therapeutic strategy for inflammatory bowel disease and inflammatory carcinogenesis from breast milk-derived probiotics

Papers (19)：

Yaopeng Hu, Wenqian Cai, Yuko Hidaka, Keizo Hiraishi, Jiehui Cang, Masanari Umemura, Utako Yokoyama, Björn C. Knollmann, Yoshihiro Ishikawa, Takayuki Fujita. Translationally controlled tumor protein interacts with connexin 43 and facilitates intercellular coupling between cardiomyocytes. Frontiers in Cell and Developmental Biology. 2025. 13
Feiyan Zhao, Keizo Hiraishi, Xiaodong Li, Yaopeng Hu, Daibo Kojima, Zhihong Sun, Heping Zhang, Lin-Hai Kurahara. Long-Term Tracking of the Effects of Colostrum-Derived Lacticaseibacillus rhamnosus Probio-M9 on Gut Microbiota in Mice with Colitis-Associated Tumorigenesis. Biomedicines. 2024. 12. 3
Yaopeng Hu, Jiehui Cang, Keizo Hiraishi, Takayuki Fujita, Ryuji Inoue. The Role of TRPM4 in Cardiac Electrophysiology and Arrhythmogenesis. International Journal of Molecular Sciences. 2023. 24. 14. 11798-11798
Keizo Hiraishi, Feiyan Zhao, Lin-Hai Kurahara, Xiaodong Li, Tetsuo Yamashita, Takeshi Hashimoto, Yoko Matsuda, Zhihong Sun, Heping Zhang, Katsuya Hirano. Lactulose Modulates the Structure of Gut Microbiota and Alleviates Colitis-Associated Tumorigenesis. Nutrients. 2022. 14. 3
Keizo Hiraishi, Lin Hai Kurahara, Kaori Ishikawa, Tetsuhiko Go, Naoya Yokota, Yaopeng Hu, Takayuki Fujita, Ryuji Inoue, Katsuya Hirano. Potential of the TRPM7 channel as a novel therapeutic target for pulmonary arterial hypertension. Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi. 2022. 58. 50-62

MISC (2)：

胡耀鵬, 平石敬三, 倉原琳, 沼田朋大, 井上隆司. 徐脈性不整脈遺伝子変異TRPM4-E7Kチャネルの数理モデルシミュレーション. 日本生理学雑誌. 2019. 81. 1. 4-4
胡耀鵬, 平石敬三, 倉原琳, 市川純, 沼田朋大, 井上隆司. 共培養系を用いた線維芽細胞による心房興奮伝播制御機構の検討. 日本生理学雑誌. 2017. 79. 1. 28-28

Books (1)：

“Chapter8 : Intestinal Fibroblast/myofibroblast TRP Channels.”, New Insights into Inflammatory Bowel Disease
2016

Lectures and oral presentations (11)：

冬虫夏草Ophiocordyceps sinensisの肺高血圧症改善効果
(第72回日本生理学会中国四国地方会 2020)
母乳由来プロバイオティクスによるAOM/DSS誘導大腸癌モデルマウスへの改善効果
(第97回日本生理学会大会 2020)
Pathophysiological contribution of TRPM7 channel to pulmonary arterial hypertension
(64th Annual Meeting of the Biophysical Society 2020)
大建中湯はTRPA1チャネルの活性化により腸管線維化を改善する
(第71回日本生理学会中国四国地方会 2019)
肺動脈高血圧症の病態形成におけるTRPM7の役割の検討
(第29回日本循環薬理学会・第55回高血圧関連疾患モデル学会合同学会 2019)

Education (3)：

Professional career (1)：

Work history (4)：

Awards (5)：

2019/11 - 第29回日本循環薬理学会・第55回高血圧関連疾患モデル学会合同学会優秀演題賞肺動脈高血圧症の病態形成におけるTRPM7の役割の検討
2019/11 - 第71回日本生理学会中国四国地方会奨励賞大建中湯はTRPA1チャネルの活性化により腸管線維化を改善する
2019/08 - 第61回日本平滑筋学会総会学術交流優秀賞肺動脈リモデリングにおけるSTAT3関連シグナルの探索
2017/08 - 第59回日本平滑筋学会総会優秀演題賞肺動脈高血圧症の病態生理における血管内皮TRPM7チャネルの役割
2016/05 - 2016 International Conference of Physiological Sciences Young Investigator Travel Award Contribution of TRPM7 and FYN to Endothelial remodeling in HUVECs and HPAECs.

Association Membership(s) (5)：

Biophysical society , 日本循環薬理学会 , 日本平滑筋学会 , 日本薬理学会 , 日本生理学会

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