Research theme for competitive and other funds (8):
2021 - 2024 腸内細菌による薬物代謝活性化の分子基盤の解明
2020 - 2024 新たな創薬資源の採集調査と新奇天然物生合成マシナリーの探索と解明
2020 - 2023 複雑骨格天然物生合成酵素の精密構造機能解析に基づく合成生物学と創薬
2020 - 2023 植物生合成酵素の機能改変と物質生産系の確立
2019 - 2022 Structure-function analysis of biosynthetic enzymes in the biosynthesis of fungal meroterpenoids
2016 - 2019 糸状菌由来テルペノイド合成酵素群の機能拡張と分子多様性の創出
2015 - 2018 Biosynthetic studies on complex natural products
2014 - 2016 Functional analysis of bacterial stilbene synthase
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Papers (71):
Yuhao Zhu, Takahiro Mori, Masayuki Karasawa, Kohei Shirai, Wenjiao Cheng, Tohru Terada, Takayoshi Awakawa, Ikuro Abe. Structure-function analysis of carrier protein-dependent 2-sulfamoylacetyl transferase in the biosynthesis of altemicidin. Nature Communications. 2024. 15. 1
Takahiro Mori, Yoshitaka Moriwaki, Kosuke Sakurada, Shuang Lyu, Stanislav Kadlcik, Jiri Janata, Aninda Mazumdar, Marketa Koberska, Tohru Terada, Zdenek Kamenik, et al. Molecular basis for the diversification of lincosamide biosynthesis by pyridoxal phosphate-dependent enzymes. Nature Chemistry. 2024
Richiro Ushimaru, Lide Cha, Shotaro Shimo, Xiaojun Li, Jared C Paris, Takahiro Mori, Kazunori Miyamoto, Lindsay Coffer, Masanobu Uchiyama, Yisong Guo, et al. Mechanistic Analysis of Stereodivergent Nitroalkane Cyclopropanation Catalyzed by Nonheme Iron Enzymes. Journal of the American Chemical Society. 2023. 145. 44. 24210-24217
Richiro Ushimaru, Yiling Ding, Takahiro Mori, Kazunori Miyamoto, Masanobu Uchiyama, Ikuro Abe. Structural and Mechanistic Insights into the C-C Bond-Forming Rearrangement Reaction Catalyzed by Heterodimeric Hinokiresinol Synthase. Journal of the American Chemical Society. 2023. 145. 40. 21966-21973
Takahiro Mori, Xin Sun, Stanislav Kadlcik, Jiri Janata, Ikuro Abe. Structure-Function Analysis of the S-Glycosylation Reaction in the Biosynthesis of Lincosamide Antibiotics. Angewandte Chemie (International ed. in English). 2023. 62. 29. e202304989