Rchr
J-GLOBAL ID：202001020700567521
Update date: May. 20, 2024
Biyani Madhu
Biyani Madhu
Affiliation and department：
Job title：
Assistant Professor
Research field (4)：
Metabolism and endocrinology
, Tumor diagnostics and therapeutics
, Evolutionary biology
, Molecular biology
Research keywords (1)：
Drug discovery, Drug development, Aptamers, Cancer, in vitro selection method, Peptide, Vitamin D3 metabolism, Biosensors, A-to-I RNA editing
Research theme for competitive and other funds (10)：
- 2023 - 2026 Study on DNA aptamer-PROTAC conjugates-based selective ADAR1 degradation for cancer therapy
- 2023 - 2024 In cellular study of newly identified aptamers inhibitors of METTL3-METTL14 complex for cancer
- 2022 - Study of binding dynamics of the aptamer-CYP24A1 complex to optimize and develop aptamers as potent and specific CYP24A1 inhibitors for cancer treatment
- 2022 - Study of the N6-methyladenosine (m6A) writer complex (METTL3-METTL14) to develop aptamer-based METTL3 inhibitors for cancer therapy
- 2021 - 2022 FY2021 WPI-NanoLSI Transdisciplinary Research Promotion Grant (TDRP-G)
- 2021 - 2022 The research partner program of the Career Design Laboratory for Gender Equality
- 2021 - 2022 Identification of aptamer molecules that specifically bind to gastric cancer stem cells
- 2021 - 2022 Study of the binding dynamic of aptamer-CYP24A1 complex to optimize and develop the aptamers as a potent and specific CYP24A1-inhibitor for cancer therapeutics
- 2020 - 2021 In vitro selection and evaluation of CYP24A1-inhibiting aptamers for improving the physiological functions of vitamin D for treatment and prevention of cancer
- 2020 - 2021 Elucidation of dynamic structural property of ADAR1 in a process of A-to-I RNA editing for development of ADAR1 inhibitors for cancer therapy
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Papers (12)：
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Madhu Biyani, Kirti Sharma, Maeda Shoei, Hinako Akashi, Masataka Nakano, Miki Nakajima, Manish Biyani. A novel aptamer-antibody sandwich electrochemical sensor for detecting ADAR1 in complex biological samples. Biosensors and Bioelectronics: X. 2024. 19. 100491-100491
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Mark B. Meyer, Carlos Bernal-Mizrachi, Daniel D. Bikle, Madhu Biyani, Moray J. Campbell, Snehal N. Chaudhari, Sylvia Christakos, Sue A. Ingles, Megan M. Knuth, Seong Min Lee, et al. Highlights from the 24th workshop on vitamin D in Austin, September 2022. The Journal of Steroid Biochemistry and Molecular Biology. 2023. 228. 106247-106247
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Madhu Biyani, Kaori Yasuda, Yasuhiro Isogai, Yuki Okamoto, Wei Weilin, Noriyuki Kodera, Holger Flechsig, Toshiyuki Sakaki, Miki Nakajima, Manish Biyani. Novel DNA Aptamer for CYP24A1 Inhibition with Enhanced Antiproliferative Activity in Cancer Cells. ACS Applied Materials & Interfaces. 2022. 14. 16. 18064-18078
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Radhika Biyani, Kirti Sharma, Kenji Kojima, Madhu Biyani, Vishnu Sharma, Tarun Kumawat, Kevin Maafu Juma, Itaru Yanagihara, Shinsuke Fujiwara, Eiichi Kodama, et al. Development of robust isothermal RNA amplification assay for lab-free testing of RNA viruses. Scientific reports. 2021. 11. 1. 15997-15997
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Madhu Biyani, Radhika Biyani, Hiromi Ushijima, Masato Saito, Yuzuru Takamura, Eiichi Tamiya, Manish Biyani. Instant enumeration of total viable bacterial counts for food quality assurance using 'DEP-On-Go' sensor. Analytical Methods. 2018. 10. 14. 1585-1592
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Books (3)：
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Animal Biotechnology 2nd Edition Models in Discovery and Translation
2020
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Animal Biotechnology: Models in Discovery and Translation
2014
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Cell-Free Protein Synthesis
京華出版社 2012
Lectures and oral presentations (29)：
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Development of an aptamer-based PROTAC for inhibition of oncogenic ADAR1 for novel cancer therapy
(The 46th Annual Meeting of the Molecular Biology Society of Japan, 23.12.6 (Wed)-8 (Fri))
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Nanoscale imaging of dynamic binding of aptamer molecules to cancer-targeting proteins by high-speed atomic force microscopy (HS-AFM)
(BICON-18)
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Nanoscale visualization of Aptamer-CYP24 complex binding dynamics in the development of aptamer therapeutics in cancer
(The 7th NanoLSI Symposium in Berlin; From Molecules to Cells and Tissue - Bridging Scales with Nanoprobe Technology)
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In vivo evaluation of a novel circular bivalent DNA aptamer for CYP24A1 inhibition to enhance vitamin D3 functionality in cancer
(2023 International Joint Meeting of the 23rd International Conference on Cytochrome P450 and the 38th Annual Meeting of the Japanese Society for the Study of Xenobiotics [2023 ICCP450/JSSX])
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SELCOS: Re-birth of Aptamer-driven Technology for Targeting Cancer Stem Cells
(India-Japan international cancer conference, Kanazawa University, July 24-25, 2023 2023)
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Education (2)：
- 2011 - Saitama University
- 2000 - Homeopathy University, Jaipur
Work history (5)：
- 2020 - 現在 Kanazawa University Drug Metabolism and Toxicology Assistant professor
- 2019 - 2020 Toyama Prefectural University Pharmaceutical Engineering Research fellow in Pharmaceutical Silicon Valley Toyama Project
- 2015 - 2019 BioDevice Technology, Ltd. Electrochemical (bio) sensors
- 2014 - 2014/09 Japan Advanced Institute of Science and Technology School of Materials Science Postdoc
- 2006 - 2014 Saitama University Functional Molecular and Biomolecular Engineering Research associate
Awards (4)：
- 2022/09 - Vitamini WORKSHOP 24th Vitamin D Workshop Young Investigator Award in the Junior Faculty category A NOVEL DNA APTAMER FOR CYP24 INHIBITION EXERTS A THERAPEUTIC EFFECT BY ENHANCING ANTI-PROLIFERATIVE FUNCTION OF VITAMIN D3 IN LUNG CANCER CELLS
- 2022/06 - AIST-INDIA DAILAB Honorarium for your lecture DNA aptamers: A new window opened for cancer
- 2000 - Outstanding academic award
- WFWP program. Japanese language speech contest
Association Membership(s) (3)：
MBSJ
, Japanese Biochemical Society
, JSSX
