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J-GLOBAL ID：202101002381537320 Update date: Sep. 30, 2024

Kasho Kazutoshi

カショウカズトシ | Kasho Kazutoshi

Affiliation and department：

Research keywords (9)： DnaA , IHF , 複製開始 , 大腸菌 , Mitochondria , Genome maintenance , PrimPol , Tau , PolDIP2

Research theme for competitive and other funds (6)：

2022 - 2025 Biochemical study about the regulatory mechanism for mitochondrial genome replication and maintenance
2021 - 2023 NLRP3依存的炎症応答に必須なミトコンドリアゲノム複製促進の分子機構の解明
2017 - 2019 複製開始を制御する核様体因子IHFの適時的な結合-解離の制御機構の解析
2015 - 2017 Regulatory mechanism for timely DARS2 activation
2014 - 2017 Genomic and functional analysis for novel long-chain inverted repeats

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Papers (20)：

Kazutoshi Kasho, Ryuji Sakai, Kosuke Ito, Wataru Nakagaki, Rion Satomura, Takafumi Jinnouchi, Shogo Ozaki, Tsutomu Katayama. Read-through transcription of tRNA underlies the cell cycle-dependent dissociation of IHF from the DnaA-inactivating sequence datA. Frontiers in microbiology. 2024. 15. 1360108-1360108
Kazutoshi Kasho, Shogo Ozaki, Tsutomu Katayama. IHF and Fis as Escherichia coli Cell Cycle Regulators: Activation of the Replication Origin oriC and the Regulatory Cycle of the DnaA Initiator. International journal of molecular sciences. 2023. 24. 14
Morigen, Monika Glinkowska, Jianping Xie, Richa Priyadarshini, Kazutoshi Kasho. Editorial: Bacterial transcription factors and the cell cycle, volume II. Frontiers in microbiology. 2023. 14. 1252924-1252924
Yukari Sakiyama, Mariko Nagata, Ryusei Yoshida, Kazutoshi Kasho, Shogo Ozaki, Tsutomu Katayama. Concerted actions of DnaA complexes with DNA unwinding sequences within and flanking replication origin oriC promote DnaB helicase loading. The Journal of biological chemistry. 2022. 102051-102051
Teppei Inatomi, Shigeru Matsuda, Takashi Ishiuchi, Yura Do, Masunari Nakayama, Shusaku Abe, Kazutoshi Kasho, Sjoerd Wanrooij, Kazuto Nakada, Kenji Ichiyanagi, et al. TFB2M and POLRMT are essential for mammalian mitochondrial DNA replication. Biochimica et biophysica acta. Molecular cell research. 2022. 1869. 1. 119167-119167

MISC (55)：

吉田瑞希, 加生和寿, 片山勉. 大腸菌染色体の複製開始促進因子DARS2とその活性化因子IHFとの適時的相互作用を制御する因子の網羅的探索. 日本遺伝学会大会プログラム・予稿集. 2023. 95th (CD-ROM)
片山勉, 吉田竜星, 盧楚元, 鶴田匠, 若杉泰敬, 加生和寿, 尾崎省吾. 細菌染色体の複製開始の分子機構:多様性に潜む普遍性. 日本遺伝学会大会プログラム・予稿集. 2023. 95th (CD-ROM)
片山勉, 吉田竜星, 鶴田匠, 興梠和真, 加生和寿, 尾崎省吾. 大腸菌染色体の開始複合体における複製ヘリカーゼ装着の多様な分子機構. 日本遺伝学会大会プログラム・予稿集. 2022. 94th (CD-ROM)
伊藤孝輔, 酒井隆至, 加生和寿, 尾崎省吾, 片山勉. Analysis of transcription regulation for the formation of datA-IHF complex promoting timely inactivation of the replication initiator DnaA. 日本分子生物学会年会プログラム・要旨集(Web). 2022. 45th
加生和寿, 片山勉. Identification of the evolutional origin of vertebrate-type mitochondrial genome replication. 日本分子生物学会年会プログラム・要旨集(Web). 2022. 45th

Education (3)：

Work history (5)：

2021/05 - 現在九州大学薬学研究院分子生物薬学分野助教
2017/11 - 2021/04 Umeå University Department of Medical Biochemistry and Biophysics
2018/04 - 2020/03 日本学術振興会海外特別研究員
2013/11 - 2017/10 九州大学薬学研究院分子生物薬学分野助教
2011/04 - 2013/09 Japan Society for the Promotion of Science

Awards (4)：

2024/06 - 日本生化学会九州支部令和6年度日本生化学会九州支部学術奨励賞染色体DNA 因子datA、DARS2 と核様体因子IHF による適時的な複製開始制御の重要性
2023/10 - 日本生化学会第20回柿内三郎記念奨励研究賞細胞周期に応じた核様体因子IHFの適時的DNA結合制御機構の解析
2019 - Seal of Excellence
2011 - 日本遺伝学会日本遺伝学会第83回大会 Best Papers賞核様体凝集蛋白質による複製開始促進因子DARS2(DnaA-reactivatingsequence2)の増殖相及び細胞周期に応じた制御機構

Association Membership(s) (3)：

日本ゲノム微生物学会 , 日本遺伝学会 , 日本生化学会

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