Mera Hisashi

Research field (1)： Orthopedics

Research theme for competitive and other funds (3)：

2019 - 2023 Elucidation of the mechanism underlying osteoclastic differentiation and functional regulation by ligand-independent GPCR activation
2016 - 2019 Functional analysis of an osteoclast-specific G protein-coupled receptor, GPR137B, and exploration of its regulatory molecules
2014 - 2017 Role of Irx3 in chondrogenic differentiation and chondrocyte maturation of mouse mesenchymal cells

Papers (12)：

Yuriko Furuya, Hisashi Mera, Maki Itokazu, Shozaburo Terai, Hiroaki Nakamura, Shigeyuki Wakitani, Hisataka Yasuda. Induction of chondrogenesis with a RANKL-binding peptide, WP9QY, in vitro and in vivo in a rabbit model. Biochemical and biophysical research communications. 2022. 602. 98-104
Yoshihiro Tamamura, Kenichi Katsube, Hisashi Mera, Maki Itokazu, Shigeyuki Wakitani. Irx3 and Bmp2 regulate mouse mesenchymal cell chondrogenic differentiation in both a Sox9-dependent and -independent manner. JOURNAL OF CELLULAR PHYSIOLOGY. 2017. 232. 12. 3317-3336
Iori Takahashi, Keigo Sato, Hisashi Mera, Shigeyuki Wakitani, Mutsumi Takagi. Effects of agitation rate on aggregation during beads-to-beads subcultivation of microcarrier culture of human mesenchymal stem cells. CYTOTECHNOLOGY. 2017. 69. 3. 503-509
Keigo Sato, Hisashi Mera, Shigeyuki Wakitani, Mutsumi Takagi. Effect of epigallocatechin-3-gallate on the increase in type II collagen accumulation in cartilage-like MSC sheets. BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY. 2017. 81. 6. 1241-1245
Nobuhiro Kasai, Hisashi Mera, Shigeyuki Wakitani, Yusuke Morita, Naohide Tomita, Mutsumi Takagi. Effect of epigallocatechin-3-o-gallate and quercetin on the cryopreservation of cartilage tissue. BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY. 2017. 81. 1. 197-199

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MISC (7)：

目良恒, 石橋宰, 高木睦, 脇谷滋之. 最先端の関節軟骨再生骨髄間葉系細胞を用いた関節軟骨再生治療の研究開発. JOSKAS. 2015. 40. 4. 114-114
糸数万紀, 目良恒, 玉村禎宏, 高木睦, 脇谷滋之. 【整形外科基礎の最前線2015】骨髄間葉系幹細胞からの軟骨様細胞シートの作製および移植(前臨床試験). 関節外科. 2015. 34. 4月増刊. 108-117
糸数万紀, 目良恒, 佐藤康史, 中村博亮, 高木睦, 脇谷滋之. ヒト骨髄細胞由来scaffold-free再生軟骨様細胞シート作製の工夫. 日本整形外科学会雑誌. 2014. 88. 8. S1629-S1629
古屋優里子, 目良恒, 糸数万紀, 中村博亮, 内田浩二, 脇谷滋之, 保田尚孝. 分化誘導ペプチドW9によるウサギ軟骨欠損の修復-軟骨細胞分化メカニズムの解析-. 日本骨代謝学会学術集会プログラム抄録集. 2014. 32nd. 259-259
目良恒, 古屋優, 糸数万紀, 吉原裕, 中村博亮, 内田浩二, 脇谷滋之, 保田尚孝. WP9QY(W9)ペプチドの関節内投与は関節軟骨欠損の修復を促進する. JOSKAS. 2014. 39. 4. 143-143

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