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J-GLOBAL ID：202101006160376610 Update date: Feb. 13, 2025

Nakajima Kohei

ナカジマコウヘイ | Nakajima Kohei

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Affiliation and department：

Research field (2)： Tumor diagnostics and therapeutics , Pharmaceuticals - analytical and physicochemistry

Research keywords (5)：光免疫療法 , 分子イメージング , 核医学診断・治療 , がん , 炎症

Research theme for competitive and other funds (6)：

2023 - 2026 がん光免疫療法の光化学反応を促進する分子を利用した新規治療薬の開発
2022 - 2025 がん特異的糖鎖抗原を用いた小児がんに対する近赤外光線免疫療法の確立:前臨床モデル
2021 - 2023 がん光免疫療法が引き起こす免疫・炎症反応の生体イメージングによる解析とその制御
2022 - 光を用いたがん関連マクロファージの特異的殺傷による新たながん治療法の開発
2020 - 2022 放射線治療におけるがん免疫の関与の解明と光免疫療法への応用

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Papers (25)：

Takehiro Chida, Aya Matsuda, Nako Maishi, Kohei Nakajima, Mineyoshi Sato, Jia Zi, Yoichi Ohiro, Mikako Ogawa, Yasuhiro Hida, Kyoko Hida. Histopathological analysis of tumor microenvironmental changes after near-infrared photoimmunotherapy. Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology. 2025
Koki Tsuchiya, Hideo Takakura, Kohei Nakajima, Naoya Ieda, Takashi Kaneko, Takeshi Hirasawa, Masato Kobayashi, Yoshihisa Yamaoka, Miya Ishihara, Tetsuya Taketsugu, et al. Piperazine based pH-responsive cyanine dyes for cancer cell photoacoustic imaging. Journal of Photochemistry and Photobiology A: Chemistry. 2024
Naoya Ieda, Hideo Takakura, Hirotaka Maeta, Takayuki Ohira, Koki Tsuchiya, Kohei Nakajima, Mikako Ogawa. Investigation of the substituent effect of indocyanine green derivatives for lymph imaging. Bioorganic & Medicinal Chemistry. 2024. 117824-117824
Chie Kojima, Junjie Yao, Kohei Nakajima, Motofumi Suzuki, Ayako Tsujimoto, Yuji Kuge, Mikako Ogawa, Akikazu Matsumoto. Attenuated polyethylene glycol immunogenicity and overcoming accelerated blood clearance of a fully PEGylated dendrimer. International Journal of Pharmaceutics. 2024. 659. 124193-124193
Takahiro Obara, Nanami Kawano, Kengo Tatsumi, Akira Katsuyama, Kohei Nakajima, Mikako Ogawa, Satoshi Ichikawa. Development of small molecule-drug conjugates based on derivatives of natural proteasome inhibitors that exhibit selectivity for PSMA-expressing cancer cells. Bioorganic & Medicinal Chemistry. 2024. 108. 117773-117773

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MISC (17)：

吉野元貴, 中島孝平, 高倉栄男, 小川美香子. 潰瘍性大腸炎におけるニコチンの抗炎症作用に関する[¹⁸F]FDGを用いた検討. JSMI Report. 2023. 16. 1. 21-25
山下柾, 松廣志乃, 高倉栄男, 中島孝平, 稲波修, 小川美香子. Analysis of X-ray responsiveness of phthalocyanine derivatives for development of caged compounds that can be used deep in vivo. 日本薬学会年会要旨集(Web). 2023. 143rd
後藤悠人, 高倉栄男, 中島孝平, 稲波修, 小川美香子. Investigation of a reaction mechanism of photoimmunotherapy using ESR. 日本薬学会年会要旨集(Web). 2023. 143rd
稲波修, 榎本将聖, 我喜屋祥, 中島孝平, 小川美香子. Analysis of radiation reaction mechanisms of hypervalent iodine compounds using ESR for the development of radiation-responsive caged compounds. 電子スピンサイエンス学会年会講演要旨集. 2023. 62nd (CD-ROM)
小河原浩輝, 高倉栄男, 中島孝平, 稲波修, 小川美香子. Analysis of azo cleavage reaction for development of X-ray induced caged compounds. 日本薬学会年会要旨集(Web). 2023. 143rd

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Patents (1)：

発光型治療具

Lectures and oral presentations (113)：

The Optimization of <SUP>211</SUP>At-astatination for Automated Synthesis
(The 12th China-Japan-Korea Symposium on Radiopharmaceutical Sciences 2024)
Combination of anti-PD-1 and radiation therapies diminishes tumor hypoxia by enhancing anti-cancer immunity
(The 12th China-Japan-Korea Symposium on Radiopharmaceutical Sciences 2024)
Development for caged compound induced by X-ray-triggered azo bond cleavage
(World Molecular Imaging Congress 2024 2024)
Enhanced anti-cancer immunity reduces hypoxia in tumor in combination therapy of anti-PD-1 and radiation therapies
(World Molecular Imaging Congress 2024 2024)
Investigation on a specific elimination of tumor-associated macrophages by near-infrared photoimmunotherapy
(World Molecular Imaging Congress 2024 2024)

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Education (4)：

2019 - 2021 Hokkaido University Graduate School of Life Science
2017 - 2019 Hokkaido University Graduate School of Life Science
2014 - 2017 Hokkaido University Faculty of Pharmaceutical Sciences Department of Pharmaceutical Sciences
2013 - 2014 Hokkaido University Faculty of Pharmaceutical Sciences

Professional career (1)：

博士(薬科学) (北海道大学)

Work history (3)：

2025/02 - 現在第一三共株式会社研究開発本部
2021/04 - 2025/01 Hokkaido University Faculty of Pharmaceutical Sciences
2020/04 - 2021/03 日本学術振興会特別研究員 DC2

Awards (12)：

2024/09 - 第10回北海道大学部局横断シンポジウム第10回北海道大学部局横断シンポジウム研究助成銅賞
2024/09 - The 12th China-Japan-Korea Symposium on Radiopharmaceutical Sciences Poster Presentation Award at CJKSRS2024
2024/06 - 第28回日本がん分子標的治療学会学術集会フラッシュトーク賞
2023/07 - 第55回日本動脈硬化学会総会・学術集会ポスター優秀賞
2022/06 - 第29回クロマトグラフィーシンポジウム優秀発表賞

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Association Membership(s) (7)：

日本動脈硬化学会 , クロマトグラフィー科学会 , Japanese Society of Nuclear Medicine , World Molecular Imaging Society , 日本癌学会 , 日本分子イメージング学会 , 日本薬学会

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